Navigation Links
UMass Amherst cell biologists identify new protein key to asymmetric cell division
Date:11/8/2012

microtubules "tracks" and anchoring in the wall like tent stakes. Until Lee and colleagues' recent discovery of She1's role, biologists believed dynein acted alone to direct the spindle apparatus between them, pulling chromosomes apart like taffy to form two daughter cells. They thought She1 seemed to be involved in dynein distribution, as it was often observed on the microtubule tracks along which dynein draws the spindle apparatus.

To explore She1's secrets, Lee and his team used Total Internal Reflection Fluorescence (TIRF) microscopy, which allows them to visualize single molecules at high resolution. They can watch the dynein engine as it powers along the microtubule tracks.

"We were curious," Lee notes. "We knew She1 was present but we didn't know why. So we decided to do some biochemistry with it in the microscope. Steven purified the protein and designed experiments to see if it interacted with the motor protein. And it did."

In fact, the UMass Amherst research team found that She1 interacts with dynein only when the motor protein is on the microtubule cable and the motor is moving on the track, never elsewhere. "We observed them colliding on the track, then binding. The new concept is that these microtubules become different," Lee adds. "Discovering that She1 can block dynein's motoring totally changed our thinking about how the spindle is being pulled in the cell."

The researchers were surprised because observing its behavior, one would predict that She1 inhibits asymmetric division by blocking dynein. It turns out that is not true. Instead, She1 actively promotes asymmetric cell division by changing its local underlying microtubules. Tracks containing She1 no longer permit dynein to pass.

It's a subtle difference, Lee acknowledges, but important. He clarifies, "We think the microtubule tracks might be 'licensed,' so to speak, by She1. The idea had been that the engine was always 'on' and pulling. However,
'/>"/>

Contact: Janet Lathrop
jlathrop@admin.umass.edu
413-545-0444
University of Massachusetts at Amherst
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. UMass Amherst researchers unravel secrets of parasites replication
2. UMass Amherst chemists develop nose-like sensor array to smell cancer diagnoses
3. UMass Amherst sleep researchers study value of preschool naps
4. Texas A&M biologists prove ZOLOFT packs potential to fight fungal meningitis
5. UCI microbiologists find new approach to fighting viral illnesses
6. Scientists identify major source of cells defense against oxidative stress
7. Molecular probes identify changes in fibronectin that may lead to disease
8. Joslin scientists identify important mechanism that affects the aging process
9. Moffitt Cancer Center researchers identify drivers of sarcoma growth and survival
10. Scientists discover marker to identify, attack breast cancer stem cells
11. Scientists identify new target to battle rheumatoid arthritis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UMass Amherst cell biologists identify new protein key to asymmetric cell division
(Date:3/6/2015)... You Wealth Revolution ( http://www.youwealthrevolution.com/info ... ‘energy’ experiment to determine if quick remote meditations ... quick ‘5 -7 minute’ remote energy and consciousness ... their life improving - often times very quickly. ... According to research, respondents saw the following common ...
(Date:3/6/2015)... Plano, TX (PRWEB) March 06, 2015 Dr. ... at Spear Education in Scottsdale, AZ. Offering programs for advanced ... from all over the world. , As a visiting ... to both “teach and learn” each time he visits Spear ... Education program, Dr. Sowell remarks, “we are training only the ...
(Date:3/6/2015)... 2015 The Public Health Accreditation ... accreditation status to seven more health departments. This week’s ... million people can now be assured that their health ... health of their communities. , Public health departments play ... of people and communities. Across the nation, health departments ...
(Date:3/5/2015)... New York, NY (PRWEB) March 05, 2015 ... first time in more than a decade. She has hinted ... not want to miss seeing her perform one last time. ... two years and this beloved country sweetheart has millions of loyal ... be touring throughout her native country, Canada, and on June 30th ...
(Date:3/5/2015)... New York, NY (PRWEB) March 05, 2015 ... to move forward in a Pennsylvania mass tort ... Common Pleas, where a jury has begun hearing ... allegations that the atypical antipsychotic medication can cause ... documents, the case in question was filed on ...
Breaking Medicine News(10 mins):Health News:250,000+ Person ‘Remote Energy’ Event has 94.2% of Respondents saying “Life Got Better” 2Health News:Plano Dentist Teaches Dentists from Around the Globe at Spear Education 2Health News:Nearly 113 Million U.S. Residents Now Reaping Benefits of National Public Health Department Accreditation 2Health News:Nearly 113 Million U.S. Residents Now Reaping Benefits of National Public Health Department Accreditation 3Health News:Shania Twain Tickets: Ticket Down Announces Shania Twain's 2015 “Rock This Country” North American Tour 2Health News:Shania Twain Tickets: Ticket Down Announces Shania Twain's 2015 “Rock This Country” North American Tour 3Health News:Risperdal Lawsuits Move Forward in Pennsylvania, as Bernstein Liebhard LLP Comments on Start of Second Gynecomastia Trial 2Health News:Risperdal Lawsuits Move Forward in Pennsylvania, as Bernstein Liebhard LLP Comments on Start of Second Gynecomastia Trial 3
... (OTC Bulletin,Board: CRDT), a leading healthcare staffing ... Bollin to Area Manager of Crdentia,s Austin,Dallas ... In this new,role, Mr. Bollin will supervise ... office locations while maintaining focus on achieving,aggressive ...
... to candidates good for supporters too, DENVER, Jan. ... week away, presidential candidates may want to heed advice,from ... their voices stay,healthy for stump speeches and pep rallies ... to others on the campaign trail such as cheering,supporters, ...
... comes to Bisphenol A (BPA) exposure from polycarbonate plastic ... old but the liquids temperature that has the most ... University of Cincinnati (UC) scientists. , Scott Belcher, PhD, ... used polycarbonate drinking bottles were exposed to boiling hot ...
... John Josef Molenda has joined Jenner,& Block,s ... Firm,s Intellectual Property,and Appellate and Supreme Court Practices., ... at Frommer Lawrence & Haug,LLP, where he concentrated ... Dr. Molenda, who has a Ph.D. in Chemistry ...
... degree program addresses growing mental health workforce,crisis, ... the,growing mental health workforce crisis, California Institute of ... program in,Community Mental Health in fall 2008., ... Psychology with a,concentration in Community Mental Health, as ...
... Wyeth and Nycomed Continue Lawsuit to Enforce PROTONIX Patent ... WYE ) and,its business partner, Nycomed, today announced ... tablets, in response to the at-risk,launch of generic pantoprazole ... December 21, 2007. Wyeth,s own generic version of PROTONIX,will ...
Cached Medicine News:Health News:Crdentia Promotes Kevin Bollin to Area Manager of Austin, Dallas and San Antonio, Texas, Markets 2Health News:Candidates Risk Harming Voice in Final Week to Super Tuesday 2Health News:Hot liquids release potentially harmful chemicals in polycarbonate plastic bottles 2Health News:California Institute of Integral Studies Launches Groundbreaking Community Mental Health Program 2Health News:California Institute of Integral Studies Launches Groundbreaking Community Mental Health Program 3Health News:Wyeth Announces Launch of Own Generic Version of PROTONIX 2Health News:Wyeth Announces Launch of Own Generic Version of PROTONIX 3
(Date:3/5/2015)... BAUDETTE, Minn. , March 5, 2015 /PRNewswire/ ... ) today announced that it has acquired the ... Acetate tablets USP 50mg, 100mg and 150mg, previously ... the overall market for this product was approximately ... Arthur S. Przybyl , President and CEO of ...
(Date:3/5/2015)... and Markets ( http://www.researchandmarkets.com/research/4q7gwz/india_pharma ) has announced ... Accelerating growth to the next level - Moving up ... offering. Domestic sales improved in 2014, ... the market,s reaction to the new drug pricing policy. ... healthy, as the momentum continues and improving economic growth ...
(Date:3/5/2015)... 2015 Soligenix, Inc. (OTCQB: SNGX) (Soligenix or ... developing products that address unmet medical needs in the ... its President and Chief Executive Officer, Christopher J. ... the 27 th Annual ROTH Conference in ... 10, 2015 at 1:00 PM Pacific Daylight Time (PDT).  ...
Breaking Medicine Technology:ANI Pharmaceuticals Acquires Generic Drug Product from Teva Pharmaceuticals 2ANI Pharmaceuticals Acquires Generic Drug Product from Teva Pharmaceuticals 3India Pharma Outlook 2015: Accelerating growth to the next level - Moving up the value chain beyond Generics 2India Pharma Outlook 2015: Accelerating growth to the next level - Moving up the value chain beyond Generics 3Soligenix to Present at the 27th Annual ROTH Conference 2Soligenix to Present at the 27th Annual ROTH Conference 3
... 2011 The 23rd Annual Transcatheter Cardiovascular Therapeutics ... Development, Ltd. ("SMT") today announced that Shuki Porath has ...  Mr. Porath will be responsible for overseeing the day-to-day ... Herzliya Pituach, Israel, and will also play a key ...
... 8, 2011 Ikaria, Inc., a critical care company ... address the significant needs of critically ill patients in ... Chairman and CEO, Daniel Tasse, will present at the ... Tasse,s presentation will be given on Tuesday, November 15, ...
Cached Medicine Technology:SMT Research & Development, Ltd. Names Shuki Porath as Vice President and General Manager, Announces TCT Presence 2SMT Research & Development, Ltd. Names Shuki Porath as Vice President and General Manager, Announces TCT Presence 3Ikaria® to Present at 2011 Lazard Capital Markets Healthcare Conference 2
Lyphochek Tumor Marker Control is a comprehensive, bilevel product designed to assess the performance of various cancer antigen tests, including esoteric tumor markers....
... Control provides the clinical laboratory with ... world for monitoring immunoassay and therapeutic ... for separate controls. Made from human ... is suitable for most methods and ...
Liquichek Immunology Control is a trilevel, liquid, comprehensive serum protein control with assayed values for a wide number of methods....
Invacare 5 Oxygen Concentrator with Sens O2, 230 VAC - Intl....
Medicine Products: