Navigation Links
UMass Amherst cell biologists identify new protein key to asymmetric cell division
Date:11/8/2012

AMHERST, Mass. Recently biologists at the University of Massachusetts Amherst led by Wei-lih Lee have identified a new molecular player in asymmetric cell division, a regulatory protein named She1 whose role in chromosome- and spindle positioning wasn't known before. Asymmetric cell division is important in the self-renewal of stem cells and because it ensures that daughter cells have different fates and functions.

When a fertilized egg develops in a fruit fly or a human being, the number of asymmetric cell divisions must be precisely balanced by symmetric cell divisions, Lee explains. He has spent years studying the cell's molecular engine called dynein, which in many cases controls how embryos accomplish asymmetric cell division, though exactly how is not completely understood.

Now, Lee and postdoctoral researcher Steven Markus, with undergraduate Katelyn Kalutkiewicz, in experiments supported by the NIH's National Institute of General Medical Sciences, have identified She 1 as the first known regulator of asymmetric cell division that inhibits the dynein engine, but surprisingly also promotes asymmetric division. Their work is described in an early online edition of Current Biology and will appear in the December 4 print edition.

Working with common yeast, Lee explains, "With this study, we've looked deeper than ever before into dynein and its role in asymmetric cell division. This is a highly conserved process that's very important to human development, to tissue differentiation and the self-renewing process of stem cells. Many had hypothesized that dynein influences the outcome of the division by pulling on the mitotic spindle, the intricate machine responsible for separating chromosomes. How dynein knows which direction to pull the spindle had become the holy grail of this research."

When a cell is ready to divide asymmetrically, dynein molecules move to its outer wall in opposite directions by riding along
'/>"/>

Contact: Janet Lathrop
jlathrop@admin.umass.edu
413-545-0444
University of Massachusetts at Amherst
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. UMass Amherst researchers unravel secrets of parasites replication
2. UMass Amherst chemists develop nose-like sensor array to smell cancer diagnoses
3. UMass Amherst sleep researchers study value of preschool naps
4. Texas A&M biologists prove ZOLOFT packs potential to fight fungal meningitis
5. UCI microbiologists find new approach to fighting viral illnesses
6. Scientists identify major source of cells defense against oxidative stress
7. Molecular probes identify changes in fibronectin that may lead to disease
8. Joslin scientists identify important mechanism that affects the aging process
9. Moffitt Cancer Center researchers identify drivers of sarcoma growth and survival
10. Scientists discover marker to identify, attack breast cancer stem cells
11. Scientists identify new target to battle rheumatoid arthritis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UMass Amherst cell biologists identify new protein key to asymmetric cell division
(Date:8/28/2015)... (PRWEB) , ... August 28, 2015 , ... ... abuse, or those who might personally be struggling with chemical dependency, may be ... from Best Drug Rehabilitation, a results-driven holistic treatment center for addiction located in ...
(Date:8/28/2015)... ... 28, 2015 , ... Drugs and alcohol abuse by employees ... new approach on solutions in his new book ":Unraveling The Psychological Mystery of ... together for meaningful group meetings. "This would educate the employees on not ...
(Date:8/28/2015)... ... August 28, 2015 , ... Dr. Gregory K. Toumayan, D.C., Q.M.E., is now ... shoulder pain, hip pain, neck pain, stiffness, muscle spasms, and numbness. ... of Illinois, and then went on to earn his title of Doctor of Chiropractic ...
(Date:8/28/2015)... ... August 28, 2015 , ... Mendon, IL, home of the Adams County Fairgrounds, ... all for a good cause. In its second year, the “Music With A Mission” ... Drug Rehabilitation. The “Mission” of “Music With A Mission” is to raise money to ...
(Date:8/28/2015)... ... 28, 2015 , ... The newest therapy to receive orphan drug status for ... time soon, according to educational website Surviving Mesothelioma. Click here to read their ... for mesothelioma last week from the FDA, will now head into Phase I clinical ...
Breaking Medicine News(10 mins):Health News:Best Drug Rehabilitation Releases New Video Outlining Patients' Personal Recovery Stories 2Health News:Best Drug Rehabilitation Releases New Video Outlining Patients' Personal Recovery Stories 3Health News:Healthpointe Welcomes Dr. Gregory K. Toumayan, Chiropractor, to Colton, Temecula, and Perris 2Health News:Healthpointe Welcomes Dr. Gregory K. Toumayan, Chiropractor, to Colton, Temecula, and Perris 3Health News:Best Drug Rehabilitation Sponsors "Music With A Mission" Concert Featuring Avenue Beat 2Health News:Surviving Mesothelioma Puts New Orphan Drug into Perspective in New Article 2
... Dec. 1 MassMutual Retirement Services Division has added ... Nonprofit activity has more than tripled in 2008 compared ... Dan Darby joined MassMutual on December 1 ... reports to M. Palmer Whitney, national managing director, nonprofit ...
... 1 The Food Allergy & Anaphylaxis Network (FAAN) ... CEO, replacing Founder Anne Munoz-Furlong, who is retiring. , ... to FAAN extensive knowledge of anaphylaxis, a severe, potentially ... Senior Director of Marketing, she led the marketing team ...
... supplements can also trigger acute organ failure, study says ... the single largest class of drugs that cause idiosyncratic ... accounts for about 13 percent of cases of acute ... most common cause of death from acute liver failure. ...
... Dry-needling, steroids effective against plantar fasciitis, researchers say ... researchers say they,ve developed a fast, effective, non-invasive ... plantar fasciitis. , Using a combination of "dry-needling" ... say their approach achieved a 95 percent success ...
... as one in five of all Americans who survive a ... emotionally paralyzed survivors of 9/11 and broken up survivors, families. ... lower the chance of developing the disorder, but thanks to ... PTSD may be just around the corner. , Prof. Joseph ...
... will die of AIDS. In fact, nearly 7,000 people die each day ... 1 is World AIDS Day, a day of awareness and outreach to help ... Day 2008 is You Can Make a Difference and ... as well as helping dispel the myths and misconceptions about HIV. , ...
Cached Medicine News:Health News:MassMutual Retirement Services Adds Two to Nonprofit Sales Team 2Health News:MassMutual Retirement Services Adds Two to Nonprofit Sales Team 3Health News:FAAN Names New CEO 2Health News:Antibiotics Largest Cause of Drug-Induced Liver Damage 2Health News:New Twist on Treatment of Foot Pain 2Health News:New Twist on Treatment of Foot Pain 3Health News:Easing the stress of trauma 2Health News:In Support of World AIDS Day, FHSSA Announces New Partnerships That Include the First In-Country Partnerships in Namibia and The Gambia 2
(Date:8/28/2015)... , Aug. 28, 2015 ... announced the addition of the "Investigation Report ... their offering. Developed by AstraZeneca plc, ... an important drug for the treatment of schizophrenia. ... quetiapine was listed in the Catalogue of Drugs ...
(Date:8/28/2015)... , Aug. 28, 2015 ... announced the addition of the "Investigation Report ... their offering. Developed by Pharmacia & ... receptor agonist which effectively reduces intraocular pressure. As ... latanoprost (under the trade name of Xalatan) entered ...
(Date:8/28/2015)... , August 28, 2015 The scientific ... collaboration with one of the leading academics in the field ... world record holder in life extension for model animals - ... biology of aging and age-related diseases, primarily, around the stability ... has just been published as "Stability analysis of a model ...
Breaking Medicine Technology:China Quetiapine Market Investigation Report 2010-2019 2China Latanoprost Market Investigation Report 2015-2019 2Gero: Physics Meets Biology to Help Defeat Aging 2Gero: Physics Meets Biology to Help Defeat Aging 3
... PARIS and NEW DELHI, India, Sept. 20 ... subsidiary of Cellectis (Alternext: ALCLS), and Helix BioService ... that they will join forces for the promotion ... India. Helix Biocon is a young company comprised ...
... A unit of the Government of Ukraine today ... a U.S. company that is alleged to be part ... vaccines and other pharmaceuticals.  The case was brought by ... procurement and storage of medicines and medical supplies for ...
Cached Medicine Technology:Cellectis bioresearch and Helix Biocon Join Forces for the Promotion of cGPS® and cGPS® Custom Kits and Cell Line Engineering Services in India 2Cellectis bioresearch and Helix Biocon Join Forces for the Promotion of cGPS® and cGPS® Custom Kits and Cell Line Engineering Services in India 3Ukrainian Government Unit Sues in U.S. - Alleges Corrupt Scheme in Vaccine Purchases 2
... Compact Sigma is designed to easily ... precise mechanical coupling eliminates clumsy time ... performed as well. Dorniers patented isocentric ... ,Positioning is simple using the Dornier ...
Used for temporary control of male urinary incontinence due to surgery or neurogenic disorder. Supplied non-sterile. Reusable. Intended for single patient use only....
... ideally suited for high volume stone centers. This ... and an advanced urological table. With the Dornier ... provides successful treatments for a full range of ... URS and PCN procedures are easy. One of ...
Used for male external catheterization due to urinary incontinence. The inflatable retention ring secures the catheter and can be easily deflated for removal. Supplied non-sterile. Reusable. Intended...
Medicine Products: