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UMD team gives drug dropouts a second chance
Date:5/8/2012

t with limited success.

Issacs and Briken say that next their team would like to increase the variety of novel acyclic CBs in order to be able to solubilize a maximal number of small chemical drug candidates, and also would like to generate CBs that can be specifically targeted -- for example to cancer cells.

Macrocycles have long been studied and used for a variety of applications from synthetic dyes to fabric softeners. Existing medical applications related to the new UMD work include "cyclodextrin" molecular containers currently used for the formulation of hydrophobic insoluble drugs that are on the market. Examples of biological macrocyclic molecules are Heme, the active site in hemoglobin (the protein in blood that transports oxygen) and the chlorin ring in chlorophyll (the green photosynthetic pigment found in plants).


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Contact: Lee Tune
ltune@umd.edu
301-405-4679
University of Maryland
Source:Eurekalert  

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