Navigation Links
UMD team gives drug dropouts a second chance
Date:5/8/2012

A cross-disciplinary team of researchers at the University of Maryland has designed a molecular container that can hold drug molecules and increase their solubility, in one case up to nearly 3000 times. Their discovery opens the possibility of rehabilitating drug candidates that were insufficiently soluble. It also offers an opportunity to improve successful drugs that could be made even better with better solubility.

The team's innovative findings were recently published in a study in Nature Chemistry, in which the authors note that "the solubility characteristics of 40-70 percent of new drug candidates are so poor that they cannot be formulated on their own, so new methods for increasing drug solubility are highly prized."

The Maryland scientists where able to increase the solubility of ten insoluble drugs by between 23 and 2,750 times, by forming container-drug complexes. They also show that their containers have low toxicity in human cell line and mice studies, and that the molecular containers can be built from inexpensive and readily available reagents.

"We already are working with drug companies to help them solubilize their interesting drug candidates and hope to get them interested in licensing our technology," says co-leader Volker Briken, an associate professor in the department of cell biology and molecular genetics and also a scientist in the Maryland Pathogen Research Institute.

The team, led by Briken and UMD Chemistry & Biochemistry Professor Lyle Isaacs, created their "new class of general-purpose solubilizing agents" based on a type of compound called cucurbit[n]urils - or CB[n]. These are 'macrocyclic' molecules made up of units of bicyclic glycoluril C4H4N4O2 monomers. The n in CB[n] refers to the number of repeat units in the macrocycle.

Many previous attempts have been made to capture drug molecules within these and other synthetic cages and capsules to increase drugs' solubility, but with limited success.

Issacs and Briken say that next their team would like to increase the variety of novel acyclic CBs in order to be able to solubilize a maximal number of small chemical drug candidates, and also would like to generate CBs that can be specifically targeted -- for example to cancer cells.

Macrocycles have long been studied and used for a variety of applications from synthetic dyes to fabric softeners. Existing medical applications related to the new UMD work include "cyclodextrin" molecular containers currently used for the formulation of hydrophobic insoluble drugs that are on the market. Examples of biological macrocyclic molecules are Heme, the active site in hemoglobin (the protein in blood that transports oxygen) and the chlorin ring in chlorophyll (the green photosynthetic pigment found in plants).


'/>"/>

Contact: Lee Tune
ltune@umd.edu
301-405-4679
University of Maryland
Source:Eurekalert  

Related medicine news :

1. Procedure gives patients with A-fib who cant take blood thinners alternative to reduce stroke
2. Image share project gives patients and physicians anytime, anywhere access to medical images
3. U.S. Gives Green Light to Publish Controversial Bird Flu Research
4. Research gives hope to detecting cancer in early stages
5. Electrical pulse treatment gives pancreatic cancer patients new hope
6. Chorus Gives Voice to Those With Alzheimers
7. Dentist Gives Advice to Keep Holiday Smiles Bright
8. Hospital gives first tomosynthesis mammograms in region this week
9. Rare Seizure Disorder Gives Clues About Brains Laughter Center
10. Dr. Albert Rizzo gives Estabrook Lecture on Dec. 2
11. George Mason University research gives hope to women with deadliest breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UMD team gives drug dropouts a second chance
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and ... explains one of the most popular and least understood books in the Holy Scriptures, ... puzzling descriptions that have baffled scholars for centuries. Many have tossed it off as ...
(Date:10/13/2017)... VA (PRWEB) , ... October 13, 2017 , ... ... of DevOps and Agile Software Development, has been awarded a contract by the ... Blanket Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the ... “America On The Brink” is the creation of published author, William Nowers. Captain ... As a WWII veteran, he spent thirty years in the Navy. Following his ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... treating sleep apnea using cutting-edge Oventus O2Vent technology. As many as ... disorder characterized by frequent cessation in breathing. Oral appliances can offer significant relief ...
(Date:10/12/2017)... ... October 12, 2017 , ... The ... demand of today’s consumer and regulatory authorities worldwide. From Children’s to Adults 50+, ... to meet the highest standard. , These products are also: Gluten Free, ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... 2017  True Health, a leader in integrated ... during National Breast Cancer Awareness month to educate ... Research recently published ... more than 10 million American women are at ... or BRCA2 and have not had testing. These mutations ...
(Date:10/7/2017)... 2017   Provista, a proven leader in ... in purchasing power, today announced a new resource area ... Newsroom is the online home for case studies, ... bios, news releases, slideshows and events. ... of resources at their fingertips, viewers can also watch ...
(Date:10/4/2017)... LAWRENCE, Mass. , Oct. 4, 2017 /PRNewswire/ ... developer of single-use, self-contained, illuminating medical devices, today ... National Health Surveillance Agency (or Agência Nacional ... ®. The first single-use, cordless surgical retractor with ... ONETRAC provides optimal access, illumination and exposure of ...
Breaking Medicine Technology: