Navigation Links
UM researcher develops new way to assess risk for chemicals
Date:12/21/2011

CORAL GABLES, FL Approximately 80,000 industrial chemicals are in use and about 700 new chemicals are introduced to commerce each year in the United States, according to the U.S. Government Accountability Office. To assess human health risks from exposure to harmful substances, James Englehardt, professor in the College of Engineering at the University of Miami, is proposing a new technique that is more efficient than current methods.

The new model reduces the data requirements 21-fold from previous models, and can predict the likelihood of illness not just from exposure to individual substances, but also from chemical mixtures. The findings are published online in advance of print, by the journal of Risk Analysis.

"The method we are proposing could be applied, for example, to drinking water containing chemical byproducts of chlorine disinfection; well water contaminated with chemicals spilled or released to the subsurface; polluted indoor or outdoor air; or food contaminated with pesticides or other chemicals," says Englehardt, principal investigator of this project.

In general, chemical contaminants do not occur individually, but rather in mixtures, and components of the mixtures can act to increase, or reduce the health effects of other mixture components, explained Englehardt.

"Previously, no generally-accepted dose-response function was known for mixtures," Englehardt says. "I therefore derived a dose-response model that theoretically can be extrapolated from high dose data to low doses of interest, for mixtures of carcinogens and non-carcinogens."

The researchers then developed a Bayesian mathematical technique to allow their model to accept various types of input information and produce a risk estimate that is rigorously more conservative the less information is available for the assessment.

"More generally, I hope to motivate others to study and apply the predictive Bayesian approach to dose-response assessment, which I strongly believe in as a basis for management of ever-progressing chemical technology and for microbial dose-response assessment as well."

The paper is titled "A Gradient Markov Chain Monte Carlo Algorithm for Computing Multivariate Maximum Likelihood Estimates and Posterior Distributions: Mixture Dose-Response Assessment." Co-authors are Ruochen Li, financial systems analyst, at the Hang Seng Bank, Shanghai, China and Xiaoguang Li, postdoctoral associate, at Fudan University, Shanghai, China.

Englehardt is now overseeing work on a method to detect risk in drinking water in real time, directly from sensor data. That work is part of a current project, sponsored by the National Science Foundation, to build an autonomous net-zero water residence hall on the University of Miami campus. All wastewater from the residence hall will be converted to drinking water, for return to the residence hall in a closed loop process. During the research, student residents will not drink or cook with the water, but will use it for all other purposes.
'/>"/>

Contact: Catharine Skipp
c.skipp@miami.edu
305-284-3667
University of Miami
Source:Eurekalert

Related medicine news :

1. Researchers identify potential target to delay metastatic pancreatic cancer and prolong survival
2. Researchers use light to measure cancer cells response to treatment
3. Boston University researcher awarded 2 NIH grants
4. MDC researchers: Ion channel makes African naked mole-rat insensitive to acid-induced pain
5. MU researchers find pet kidney injuries are similar to human kidney injuries
6. UC Irvine researchers urge caution when buying noisy toys
7. Ohio State researchers discover hereditary predisposition of melanoma of the eye
8. Psychology researcher finds that second-guessing ones decisions leads to unhappiness
9. Researchers investigate link between autoimmune diseases and wounds that dont heal
10. Researchers describe a new genetic program that converts static cells into mobile invasive cells
11. UIC researchers discover how cells limit inflammation in lung injury
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/18/2017)... ... 18, 2017 , ... CannaKids, a California Cooperative Cooperation that specializes in the ... the WORLDZ Summit, taking place in Hollywood from July 31-August 1, the Company’s ... cannabis for both pediatric and adult patients, and how the path has led her ...
(Date:7/18/2017)... ... 2017 , ... Doctors on Liens, the leading network of ... who offer the most effective and efficient care on a lien basis. Doctors ... each patient receives prompt and courteous service, same or next day appointments, and ...
(Date:7/18/2017)... ... July 19, 2017 , ... USHEALTH Group, ... Responsibility Initiative in the prestigious CEO World Awards®. The coveted annual CEO ... products and services, CEO case studies, corporate social responsibility, and milestones from every ...
(Date:7/17/2017)... ... ... McGraw Family Pledges $3 Million for New Learning Center at Norwalk Hospital, New ... NORWALK, Connecticut – July 17, 2017 – The McGraw family, founders of global multimedia ... up to $3 million in a challenge gift to establish the new McGraw Family ...
(Date:7/17/2017)... ... July 17, 2017 , ... Western University of Health Sciences ... Higher Education for the sixth consecutive year, and also made the Honor Roll ... and Lebanon, Oregon, was recognized in seven categories: Collaborative Governance, Compensation & Benefits, ...
Breaking Medicine News(10 mins):
(Date:7/10/2017)... July 10, 2017  BDI Group subsidiary Pathway ... support services organization serving specialty pharmacies, home infusion ... of four significant, value-added member programs designed to ... manage reimbursement and improve access and affordability for ... Pathway ...
(Date:7/5/2017)... Wolfmet 3D  printed tungsten collimator manufactured by M&I Materials ... combine to progress molecular radiotherapy imaging. In molecular ... to accurately quantify the radiation absorbed by those patients undergoing ... of this radiotherapy treatment has been available — that is, ... ...
(Date:7/1/2017)... Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH) today announced ... broadcast live over the Internet on Thursday, July 27, 2017, ... quarterly results will be made available at 7:30 a.m. Eastern ... live audio webcast can be accessed via Zimmer Biomet,s Investor ... for replay following the conference call. ...
Breaking Medicine Technology: