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UM School of Medicine scientists find new malaria vaccine is safe and protective in children
Date:2/3/2010

ral Mali. The children were randomly assigned to receive either one of three escalating doses of the malaria vaccine or a control rabies vaccine. All three doses of the vaccine proved to be safe and well tolerated, and all three doses also showed very strong antibody responses that were sustained for at least a year.

Based on the vaccine's apparent success in this early trial, the same international team of U.S., Malian and European investigators now are subjecting it to further study in a much larger trial of 400 Malian children to evaluate its effectiveness against malaria disease. That study also will examine whether the vaccine though it is based on a single strain of malaria can protect against the broad array of malaria parasites that exist. The scientists hope the vaccine could be combined with other vaccines to create a multi-component immunization that is highly protective.

"The University of Maryland employs hundreds of researchers worldwide in 23 countries outside of its home campus in Baltimore," says E. Albert Reece, M.D., Ph.D., M.B.A., dean of the School of Medicine, vice president for medical affairs of the University of Maryland and the John Z. and Akiko K. Bowers Distinguished Professor. "Dr. Plowe is a world-leading malaria researcher, and this groundbreaking work is representative of the global impact of the Center for Vaccine Development and the rest of the University of Maryland School of Medicine. I hope this study leads to a lifesaving vaccine for the children of Africa."


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Contact: Karen Buckelew
kbuckelew@som.umaryland.edu
410-706-7590
University of Maryland Medical Center
Source:Eurekalert

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