Navigation Links
UK study: Epigenetic changes play a key role in development of chemo resistance in BCa
Date:3/18/2013

to be associated with chemotherapy response (p=<0.001).

Supervised analysis identified ~2700 Methylation Variable Positions (MPVs) to be associated with chemotherapy response. Hierarchical clustering of the MVPs associated with chemotherapy response, defined three clusters, 1) chemo sensitive,2) chemo resistant and 3) a mixed cluster with a hypomethylation phenotype. The MVPs associated with resistance include novel genes such as MEIS2, PROM1 and MAP1LC3A, as well as genes previously associated with resistance other tumours, such as MEST and MLH1.

"These data suggest that epigenetic alterations are potential key drivers in the development of chemo resistance in bladder cancer. As well as providing novel insight into mechanisms of drug resistance, we have identified putative candidate biomarkers for further evaluation in future clinical studies, including potential stratification biomarkers in clinical trials of epigenetic therapies that reverse the acquired resistance phenotype," the researchers concluded.


'/>"/>

Contact: Ivanka Moerkerken
i.moerkerken@uroweb.org
31-026-389-0680
European Association of Urology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New study: Incidence and mortality of PCa after termination of PSA-based screening
2. Study: Smoking Increases HPV Risks; polyDNA Recommends Gene-Eden-VIR Against HPV
3. Omega XL Reports New Independent Study: Omega-3s Can Boost Children’s IQ
4. Study: 15% of Children Ages 10 - 14 Consider Using Steroids; polyDNA Recommends Muxscle for Safe Muscle Building
5. Study: Dynamic new software improves care of aging brain
6. Bel Marra Health Reports on a New Study: Female Obesity Could Be Due to Less Participation in Household Tasks
7. Study: Steroid Abuse in Teens is Increasing; polyDNA Recommends Muxscle for Safe Muscle Building
8. Study: Catheter-based varicose vein treatments more cost-effective
9. Penn study: Financial incentives affect prostate cancer treatment patterns
10. Study: Mega Vitamins Wont Help After Heart Attack, Chelation Treatment Might
11. Study: Diabetic medication may protect patients from developing heart failure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2015)... ... ... The PT Outcomes Registry is an organized system for collecting data to ... is being developed by the American Physical Therapy Association (APTA). , Al Amato, PT, ... contribute FOTO Outcomes measures as one of the primary global outcomes measures to be ...
(Date:8/31/2015)... (PRWEB) , ... August 31, 2015 , ... Sculpted Contours ... of Atlanta’s Women of Power and Influence by Modern Luxury’s The Atlantan Magazine. ... the business as well as Kathy King. Her idea and vision to bring ...
(Date:8/31/2015)... ... August 31, 2015 , ... Dental ... Western University of Health Sciences to learn more about its integrated approach to ... Dental Sciences and Institute of Cellular Medicine at Newcastle University, and Susan Bissett, ...
(Date:8/31/2015)... Angeles, CA (PRWEB) , ... August 31, 2015 , ... ... 16 by CDA Press, the expert guest author addressed the topic of treating back ... author explained that, while steroids were shown to slightly improve physical function in patients ...
(Date:8/31/2015)... ... ... The Lisle family law firm of Momkus McCluskey, LLC is pleased ... earn a “Leading Lawyers” distinction. , The “Leading Lawyers” distinction is ... nomination process is based on statewide peer survey nominations and the approval of the ...
Breaking Medicine News(10 mins):Health News:FOTO Selected as Official Registry Partner with Physical Therapy Outcomes Registry 2Health News:Sculpted Contours Owner Selected One of Atlanta's Women of Power and Influence by Modern Luxury's The Atlantan Magazine 2Health News:Sculpted Contours Owner Selected One of Atlanta's Women of Power and Influence by Modern Luxury's The Atlantan Magazine 3Health News:Western Diabetes Institute Collaborates with UK team 2Health News:Western Diabetes Institute Collaborates with UK team 3Health News:Western Diabetes Institute Collaborates with UK team 4Health News:Article on Steroid Use for Back Pain Highlights the Effectiveness of Surgery in Treating Disk Pain, says Dr. Seyed M. Rezaian 2Health News:DuPage County Family Law Attorney Named Illinois Leading Lawyer 2
... re-evaluated, experts say, , , TUESDAY, May 26 (HealthDay ... faster, giving acid-suppressing medications to many hospital patients ... in the hospital, new research suggests. , In ... shown to prevent serious gastrointestinal problems caused by ...
... May 26 Advancing the ... Clinic,s family of blogs. "It,s aimed at the public, but ... blog editor Bob Nellis of Mayo,s Public Affairs Department.Mayo Clinic ... with audiences ranging from journalists to referring physicians. Advancing ...
... proven what baseball players have known for more than a ... brain. , At the fifth annual international Best Visual Illusion ... entry called "The Break of the Curve Ball." The ... American University professor, challenges the human visual system and brain ...
... Medical Center of Central Georgia has cut ... along the entire Emergency Service Line, including related inpatient ... leadership initiated the project after patient dissatisfaction with wait ... create a strategy for reducing patient throughput, hospital leadership ...
... is partnering with schools to reduce childhood obesity ... life, Secretary of Health Everette James and Secretary ... visited Albert Gallatin South Middle School in Point ... aimed at increasing physical activity for middle school ...
... 26 Alexian Brothers Medical Center dedicated its ... 21. The 200,000 square-foot, five-story, patient complex ... all private rooms, and will centralize all outpatient ... imaging (MRI), diagnostic imaging, nuclear medicine, ultrasound testing, ...
Cached Medicine News:Health News:Acid-Suppressing Meds May Boost Pneumonia Risks 2Health News:Acid-Suppressing Meds May Boost Pneumonia Risks 3Health News:Mayo Clinic Launches Medical Science Blog 2Health News:'Curve ball' wins international illusion contest 2Health News:Compirion Healthcare Cuts Emergency Department Throughput by 50% at the Medical Center of Central Georgia 2Health News:Compirion Healthcare Cuts Emergency Department Throughput by 50% at the Medical Center of Central Georgia 3Health News:Compirion Healthcare Cuts Emergency Department Throughput by 50% at the Medical Center of Central Georgia 4Health News:Compirion Healthcare Cuts Emergency Department Throughput by 50% at the Medical Center of Central Georgia 5Health News:Pennsylvania Secretaries of Health, Education Announce New Grant Initiatives to Curb Childhood Obesity, Boost Physical Activity in Schools 2Health News:Alexian Brothers Medical Center Opens New Patient Tower 2
(Date:8/31/2015)... 31, 2015  The departments of Drug and Alcohol ... Gaudenzia Concept 90 to raise awareness for International Overdose ... Pennsylvania and help more Pennsylvanians ... recovery through the Building Bridges to Recovery ... every day to a disease that is fully treatable, ...
(Date:8/31/2015)... and MOUNTAIN VIEW, Calif. ... SNY ; EURONEXT: SAN) and the life sciences ... to improve care and outcomes for people with type ... in diabetes treatments and devices with Google,s expertise in ... companies will explore how to improve diabetes care by ...
(Date:8/31/2015)... , Aug. 31, 2015  Asterias Biotherapeutics, Inc. ... the emerging field of regenerative medicine, today announced ... Chicago -based Rush University Medical ... activity of escalating doses of AST-OPC1 (oligodendrocyte progenitor ... motor complete cervical spinal cord injury (SCI). This ...
Breaking Medicine Technology:Pennsylvania Departments of Drug & Alcohol Programs and Health Kick-off Second Annual Building Bridges to Recovery Initiative 2Sanofi to Collaborate with Google Life Sciences to Improve Diabetes Health Outcomes 2Sanofi to Collaborate with Google Life Sciences to Improve Diabetes Health Outcomes 3Sanofi to Collaborate with Google Life Sciences to Improve Diabetes Health Outcomes 4Sanofi to Collaborate with Google Life Sciences to Improve Diabetes Health Outcomes 5Sanofi to Collaborate with Google Life Sciences to Improve Diabetes Health Outcomes 6Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 4Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 5Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 6
... in the New England ... and JACKSONVILLE, Fla., March 24 A study published ... Medicine suggests that intensive blood glucose (sugar) control ... does not improve outcomes and is associated with an ...
... 24 Anthera Pharmaceuticals, Inc., a privately held biopharmaceutical company ... of safety and efficacy data from the first cohort of ... recommended that Anthera,s Phase II clinical trial, known as the ... P hospholipase in A cute C hes ...
Cached Medicine Technology:Joint Statement from the American Diabetes Association and American Association of Clinical Endocrinologists on the NICE-SUGAR Study on Intensive Versus Conventional Glucose Control in Critically Ill Patients 2Joint Statement from the American Diabetes Association and American Association of Clinical Endocrinologists on the NICE-SUGAR Study on Intensive Versus Conventional Glucose Control in Critically Ill Patients 3Joint Statement from the American Diabetes Association and American Association of Clinical Endocrinologists on the NICE-SUGAR Study on Intensive Versus Conventional Glucose Control in Critically Ill Patients 4Following Encouraging Results Anthera to Continue IMPACTS Trial for the Prevention of Acute Chest Syndrome in Patients With Sickle Cell Disease 2Following Encouraging Results Anthera to Continue IMPACTS Trial for the Prevention of Acute Chest Syndrome in Patients With Sickle Cell Disease 3
The Natural Selection family of specialty allografts is spinal concepts response to surgeon requests for spinal allograft devices to eliminate the need for painful autograft harvesting....
Transcranial vascular DWL doppler....
Transcranial vascular DWL doppler....
... Neurocare is a full-featured physiologic testing system offered ... contains many of the features of our flagship ... economical price. , ,The smaller size of the ... environment, the physician's office, a mobile service or ...
Medicine Products: