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UK study: Epigenetic changes play a key role in development of chemo resistance in BCa
Date:3/18/2013

to be associated with chemotherapy response (p=<0.001).

Supervised analysis identified ~2700 Methylation Variable Positions (MPVs) to be associated with chemotherapy response. Hierarchical clustering of the MVPs associated with chemotherapy response, defined three clusters, 1) chemo sensitive,2) chemo resistant and 3) a mixed cluster with a hypomethylation phenotype. The MVPs associated with resistance include novel genes such as MEIS2, PROM1 and MAP1LC3A, as well as genes previously associated with resistance other tumours, such as MEST and MLH1.

"These data suggest that epigenetic alterations are potential key drivers in the development of chemo resistance in bladder cancer. As well as providing novel insight into mechanisms of drug resistance, we have identified putative candidate biomarkers for further evaluation in future clinical studies, including potential stratification biomarkers in clinical trials of epigenetic therapies that reverse the acquired resistance phenotype," the researchers concluded.


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Contact: Ivanka Moerkerken
i.moerkerken@uroweb.org
31-026-389-0680
European Association of Urology
Source:Eurekalert

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