Navigation Links
UK study: Epigenetic changes play a key role in development of chemo resistance in BCa
Date:3/18/2013

Milan, 16 March 2013 - At the 28th Annual EAU Congress currently ongoing in Milan until Tuesday, W. Tan and colleagues presented their study on neoadjuvant cisplatin-based chemotherapy which showed that epigenetic changes are potential key drivers in the development of chemo resistance in bladder cancer.

Neoadjuvant cisplatin-based chemotherapy is recommended for patients with muscle invasive bladder cancer. Cisplatin-based regimes have similar efficacy with complete response in 30% a survival advantage if 16% (HR, 0.84;CI 0.72 to 0.99), wrote Tan of the UCL, Dept. of Surgery and Interventional Science in London, the UK.

According to the researchers, the ability to identify a biomarker which is able to predict response to treatment would increase pathological complete response rates and spare nonresponders adverse events of chemotherapy. DNA hypermethylation has been implicated in chemotherapy resistance in cancers.

"We hypothesised that DNA methylation may not only represent the mechanisms for the acquisition of resistance, but may also be a potential biomarker to predict response to platinum based chemotherapy in bladder cancer," wrote Tan, lead author of the study titled "Epigenetic alterations associated with neo-adjuvant chemotherapy resistance in bladder cancer."

In the study, DNA was extracted from 48 muscular invasive bladder tumours, taken prior to the patient to receiving a platinum based neo-adjuvant chemotherapy, all tumours had >80% tumour content. 1ug of DNA was bisulphite converted using the EZDNA Bisulfite Conversion Kit (Zymo Research). Genome-wide DNA methylation profiles were generated using the Infinium HumanMethylation 450K BeadChip (Illumina).

According to the researchers, the analysis suggests acquired resistance is associated with global hypermethylation in both primary tumours and paired cell lines. Singular value decomposition (SVD) analysis revealed the strongest methylation signature
'/>"/>

Contact: Ivanka Moerkerken
i.moerkerken@uroweb.org
31-026-389-0680
European Association of Urology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New study: Incidence and mortality of PCa after termination of PSA-based screening
2. Study: Smoking Increases HPV Risks; polyDNA Recommends Gene-Eden-VIR Against HPV
3. Omega XL Reports New Independent Study: Omega-3s Can Boost Children’s IQ
4. Study: 15% of Children Ages 10 - 14 Consider Using Steroids; polyDNA Recommends Muxscle for Safe Muscle Building
5. Study: Dynamic new software improves care of aging brain
6. Bel Marra Health Reports on a New Study: Female Obesity Could Be Due to Less Participation in Household Tasks
7. Study: Steroid Abuse in Teens is Increasing; polyDNA Recommends Muxscle for Safe Muscle Building
8. Study: Catheter-based varicose vein treatments more cost-effective
9. Penn study: Financial incentives affect prostate cancer treatment patterns
10. Study: Mega Vitamins Wont Help After Heart Attack, Chelation Treatment Might
11. Study: Diabetic medication may protect patients from developing heart failure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... Recently, iFitDress.com, the popular online supplier of wedding dresses and ... of black one-shoulder cocktail dresses . In addition, all ... at discounted prices, up to 70% off. , ... weeks only. You know, we have thousands of frequent callers ... new items can visit our website for more details. The ...
(Date:12/25/2014)... Recently, BellasDress has launched its Christmas ... BellasDress has chosen their best-selling lace wedding dresses, vintage ... holiday season. , Now, BellasDress.com features popular women’s ... at discount prices. The business hopes everyone can have ... , “All our elegant products are made with ...
(Date:12/25/2014)... FL (PRWEB) December 25, 2014 When head ... find themselves in a frenzy to get rid of it ... But families in Coral Gables now have the solution right ... second salon clinic location, Lice Troopers provides full spectrum head ... the Coral Gable area, including Sunset, Key Biscayne, Brickell, Coconut ...
(Date:12/25/2014)... News) -- The risk of burns from fires and ... to be extra cautious, an expert says. "Between ... increase in patients coming in with burns," said Dr. ... Firefighters Burn Center of Stony Brook University Hospital in ... joy, but if not careful, could quickly turn tragic," ...
(Date:12/25/2014)... Dennis Thompson HealthDay Reporter ... closing in on a "fountain of youth" drug that can ... older adults, a new study suggests. Seniors received a ... that targets a genetic signaling pathway linked to aging and ... The experimental medication, a version of the drug ...
Breaking Medicine News(10 mins):Health News:iFitDress.com: Black One-Shoulder Cocktail Dresses for 2015 2Health News:BellasDress.com’s Christmas Sale: Trendy Wedding Dresses With Big Discounts 2Health News:Coral Gables Florida Gets Ready to Be Lice-Free with Lice Troopers 2Health News:Don't Let Burns Mar Your Holidays 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 3
... , NEW YORK, Aug. 3 Sports ... 24 (th) Annual Great Sports Legends Dinner ... Hotel in the famed Grand Ballroom. Bob Costas will ... Paralysis, a nonprofit organization that serves as the fundraising arm of The ...
... , BOCA RATON, Fla., Aug. 3 MadZone ... international PR firm, TransMedia Group, to publicize its wackiest of all ... while eating ( www.knifeandforklift.com ). ... the Knife and Forklift sets are a sleek combo of utensils ...
... ABU DHABI, UAE, August 3 The region,s first and ... from 22nd -,25th November 2009 at the Hilton Hotel in ... with global military medical leaders and,experts from the British Army, ... Swedish Armed Forces Centre for,Defence Medicine, NATO Centre of Excellence ...
... 3, 2009 The new anti-wrinkle facial filler Dysport, which ... frown lines between the eyes, according to users and independent ... Medical Center. "Our study confirmed that Dysport (abobotulinumtoxinA) is ... Rod Rohrich, chairman of plastic surgery at UT Southwestern and ...
... , EAST BRUNSWICK, N.J., Aug. 2 ... the Company has received a complete response letter from the U.S. ... at this time approve the Company,s Biologics License Application (BLA) for ... to conventional therapy. , , The complete ...
... West African woman,s infection suggests the virus continues to change ... time, researchers have found evidence that the AIDS virus traveled ... to evolve even as scientists race to vanquish it. , ... African country of Cameroon carried a strain of the AIDS ...
Cached Medicine News:Health News:Sports Icons Troy Aikman, Clyde Drexler, Mike Piazza, Ivan Lendl and Dara Torres are Among the Elite Named 2009 'Great Sports Legends' 2Health News:Sports Icons Troy Aikman, Clyde Drexler, Mike Piazza, Ivan Lendl and Dara Torres are Among the Elite Named 2009 'Great Sports Legends' 3Health News:Sports Icons Troy Aikman, Clyde Drexler, Mike Piazza, Ivan Lendl and Dara Torres are Among the Elite Named 2009 'Great Sports Legends' 4Health News:Madzone Marketing LLC Taps TransMedia Group to Provide Publicity Lift to Knife and Forklift(TM) 2Health News:Brand New Conference on Developing 21st Century Military Medical Capabilities to be Held in Abu Dhabi 2Health News:Dysport proves safe, effective anti-wrinkle treatment, UT Southwestern plastic surgeons find 2Health News:Savient Pharmaceuticals Receives Complete Response Letter from U.S. Food and Drug Administration for KRYSTEXXA(TM) 2Health News:Savient Pharmaceuticals Receives Complete Response Letter from U.S. Food and Drug Administration for KRYSTEXXA(TM) 3Health News:Savient Pharmaceuticals Receives Complete Response Letter from U.S. Food and Drug Administration for KRYSTEXXA(TM) 4Health News:Savient Pharmaceuticals Receives Complete Response Letter from U.S. Food and Drug Administration for KRYSTEXXA(TM) 5Health News:Savient Pharmaceuticals Receives Complete Response Letter from U.S. Food and Drug Administration for KRYSTEXXA(TM) 6Health News:Scientists ID First Human With Gorilla Strain of HIV 2
(Date:12/22/2014)... DUBLIN , Dec. 22, 2014 Research and ... addition of the "US Self-monitoring Blood Glucose Market" ... http://photos.prnewswire.com/prnh/20130307/600769 This market insight focuses ... in the United States . Reimbursement ... studied. Thorough product analyses for more than 73 SMBG ...
(Date:12/22/2014)... 2014  ConvaTec, a privately-held medical products and technologies ... Interim Chief Executive Officer of the company, effective December ... Berger .  "The Board of Directors of ConvaTec thanks ... the past three years," said Magnus Lundberg , ... confident that the company is well positioned for the ...
(Date:12/22/2014)... Mass , Dec. 22, 2014 /PRNewswire/ -- RXi ... biotechnology company focused on discovering, developing and commercializing ... RNA-targeted technologies, today issued the following open letter ... Cauwenbergh , Dr. Med. Sc. Dear ... days a number of inaccurate statements posted on ...
Breaking Medicine Technology:US Self-monitoring Blood Glucose Market 2ConvaTec Names Paul Moraviec Interim CEO Effective December 22, 2014 2RXi Pharmaceuticals Issues Open Letter to Shareholders 2RXi Pharmaceuticals Issues Open Letter to Shareholders 3RXi Pharmaceuticals Issues Open Letter to Shareholders 4RXi Pharmaceuticals Issues Open Letter to Shareholders 5RXi Pharmaceuticals Issues Open Letter to Shareholders 6
... (NYSE: DHR ) announced that Executive Vice President ... at the Goldman Sachs Global Industrials Conference in New York, ... The company also announced that President and Chief Executive Officer, ... W. Baird Industrial Conference in Chicago, Illinois on Tuesday, November ...
... (Nasdaq: ITMN ) today announced results from ... September 30, 2010.  InterMune also highlighted its recent clinical ... financial guidance for 2010.   Dan Welch, ... "Earlier this month we announced the sale of our ...
Cached Medicine Technology:InterMune Reports Third Quarter 2010 Financial Results 2InterMune Reports Third Quarter 2010 Financial Results 3InterMune Reports Third Quarter 2010 Financial Results 4InterMune Reports Third Quarter 2010 Financial Results 5InterMune Reports Third Quarter 2010 Financial Results 6InterMune Reports Third Quarter 2010 Financial Results 7InterMune Reports Third Quarter 2010 Financial Results 8
Stainless steel lancet blade in stainless steel....
In Stainless steel. Available in 1.5, 2.0,3.0 & 3.5 MM...
AXIOM Multistar is a ceiling-mounted single plane C-Arm system for universal angiography, diagnostics and intervention...
... The Allura Xper FD10 supports the cardiac ... that allows personalization of personalized user settings. ... tableside in one intuitive user interface. For ... and StentBoost can be controlled from tableside.,The ...
Medicine Products: