Navigation Links
UK study: Epigenetic changes play a key role in development of chemo resistance in BCa
Date:3/18/2013

Milan, 16 March 2013 - At the 28th Annual EAU Congress currently ongoing in Milan until Tuesday, W. Tan and colleagues presented their study on neoadjuvant cisplatin-based chemotherapy which showed that epigenetic changes are potential key drivers in the development of chemo resistance in bladder cancer.

Neoadjuvant cisplatin-based chemotherapy is recommended for patients with muscle invasive bladder cancer. Cisplatin-based regimes have similar efficacy with complete response in 30% a survival advantage if 16% (HR, 0.84;CI 0.72 to 0.99), wrote Tan of the UCL, Dept. of Surgery and Interventional Science in London, the UK.

According to the researchers, the ability to identify a biomarker which is able to predict response to treatment would increase pathological complete response rates and spare nonresponders adverse events of chemotherapy. DNA hypermethylation has been implicated in chemotherapy resistance in cancers.

"We hypothesised that DNA methylation may not only represent the mechanisms for the acquisition of resistance, but may also be a potential biomarker to predict response to platinum based chemotherapy in bladder cancer," wrote Tan, lead author of the study titled "Epigenetic alterations associated with neo-adjuvant chemotherapy resistance in bladder cancer."

In the study, DNA was extracted from 48 muscular invasive bladder tumours, taken prior to the patient to receiving a platinum based neo-adjuvant chemotherapy, all tumours had >80% tumour content. 1ug of DNA was bisulphite converted using the EZDNA Bisulfite Conversion Kit (Zymo Research). Genome-wide DNA methylation profiles were generated using the Infinium HumanMethylation 450K BeadChip (Illumina).

According to the researchers, the analysis suggests acquired resistance is associated with global hypermethylation in both primary tumours and paired cell lines. Singular value decomposition (SVD) analysis revealed the strongest methylation signature
'/>"/>

Contact: Ivanka Moerkerken
i.moerkerken@uroweb.org
31-026-389-0680
European Association of Urology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New study: Incidence and mortality of PCa after termination of PSA-based screening
2. Study: Smoking Increases HPV Risks; polyDNA Recommends Gene-Eden-VIR Against HPV
3. Omega XL Reports New Independent Study: Omega-3s Can Boost Children’s IQ
4. Study: 15% of Children Ages 10 - 14 Consider Using Steroids; polyDNA Recommends Muxscle for Safe Muscle Building
5. Study: Dynamic new software improves care of aging brain
6. Bel Marra Health Reports on a New Study: Female Obesity Could Be Due to Less Participation in Household Tasks
7. Study: Steroid Abuse in Teens is Increasing; polyDNA Recommends Muxscle for Safe Muscle Building
8. Study: Catheter-based varicose vein treatments more cost-effective
9. Penn study: Financial incentives affect prostate cancer treatment patterns
10. Study: Mega Vitamins Wont Help After Heart Attack, Chelation Treatment Might
11. Study: Diabetic medication may protect patients from developing heart failure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/1/2015)... Adults who are not legally married ... or universal policies can now use the QuotesPros.com portal ... insurance companies for single adults can now be researched ... . , The rate plans that nationwide agencies are ... a number of life protection policies. The term, universal ...
(Date:3/1/2015)... New York, New York (PRWEB) March 01, 2015 ... Wright Profemur hip lawsuit (( http://www.consumerinjurylawyers.com/wright-profemur-hip-replacement ) scheduled ... that the defense must prepare a witness to ... implant played in the development of the Profemur ... Order filed in U.S. District Court, Northern District ...
(Date:3/1/2015)... The number of transvaginal mesh lawsuits ... few weeks in two New Jersey litigations where attorneys ... Firm announces. , A Case List updated on ... County proceeding established for products manufactured by Johnson & ... earlier, when 90 fewer cases had been centralized. Additionally, ...
(Date:3/1/2015)... ERISAPros is pleased to announce ... the professional staff of its Compliance Department. , Evelyn ... State University-Mortiz College of Law. Prior to joining ERISAPros, ... several Fortune 500 companies as well as several privately ... Her experiences range from benefit plan design, vendor management, ...
(Date:3/1/2015)... March 01, 2015 Theme and plugin ... transition pack for Final Cut Pro X ... style transitions to any FCPX editors project.” Said Christiana ... users the tools needed to easily drag and drop ... user gets many different controls over the parameters of ...
Breaking Medicine News(10 mins):Health News:Best Life Insurance Companies for Single Adults Now Searchable at Insurance Website 2Health News:Wright Profemur Hip Lawyers at Bernstein Liebhard LLP Comment on Court’s Decision Regarding Testimony Pertaining to Prototype for Profemur Hip Replacement 2Health News:Wright Profemur Hip Lawyers at Bernstein Liebhard LLP Comment on Court’s Decision Regarding Testimony Pertaining to Prototype for Profemur Hip Replacement 3Health News:Bernstein Liebhard LLP Comments on Case List Growth in New Jersey Transvaginal Mesh Litigations, Where Firm Attorneys are Representing Hundreds 2Health News:Bernstein Liebhard LLP Comments on Case List Growth in New Jersey Transvaginal Mesh Litigations, Where Firm Attorneys are Representing Hundreds 3Health News:Bernstein Liebhard LLP Comments on Case List Growth in New Jersey Transvaginal Mesh Litigations, Where Firm Attorneys are Representing Hundreds 4Health News:ERISAPros Recruits Evelyn King, J.D. and Carolyn Roddy, J.D. to its Professional Staff 2Health News:Announcing a New Transition Pack from Pixel Film Studios, Transccordion for Final Cut Pro X 2
... to a new study, lack of sleep in children, ... the University of Laval's faculty of medicine studied 422 ... the weight, height, and waist size of each participant. ... lifestyle and socio-economic status through phone interviews with their ...
... finding about latest treatments available and practical cancer advice ... cancer study. Clive Seale, a sociology professor, has conducted ... to gender. The findings of the present study can ... help cancer patients. ,Questions were raised among ...
... Public Health Ministry of Afghanistan said on Sunday, that they ... called "Health for All and Health by All", is being ... conference being held in Afghanistan over the past four years. ... meeting to discuss the need for mutual cooperation to curb ...
... Marine Resources has dismissed the possibility of bird flu outbreak ... of chickens in the Bondoukou region were not due to ... of the death is still unknown. It has however been ... the chickens were negative for the bird flu virus. The ...
... go to hospitals with injuiries due to falls most of ... Medical// Journal of Australia. ,38 per cent or ... hospital cases. ,Associate Professor David Fonda, director of ... and incorporated a falls prevention program into the aged ...
... they will live longer than their ancestors, but do not ... available// for long-term care. ,“We spend more ... than we do when selecting a nursing home or assisted ... A&M Health Science Center School of Rural Public Health and ...
Cached Medicine News:Health News:Gender Difference In Reaction To Cancer 2Health News:Afghanistan Hosting A UN Funded Regional Health Conference 2
(Date:2/27/2015)... Calif., Feb. 27, 2015 Isis Pharmaceuticals, Inc. ... outperformed both its pro forma net operating loss (NOL) ... a strong financial position.  Isis, significantly improved financial results ... $230 million in payments the Company received from its ... 2014 was a nearly 60% improvement over its 2013 ...
(Date:2/27/2015)... , Feb. 27, 2015  Boston Scientific Corporation ... in the Barclays 2015 Annual Healthcare Conference on March ... Dan Brennan , executive vice president and ... president, Investor Relations, will participate in a 25-minute question ... analyst at approximately 1:05 p.m. ET. Following a 5-minute ...
(Date:2/27/2015)... KING OF PRUSSIA, Pa. , Feb. 27, 2015 ... part of its ongoing commitment to the global bleeding ... it is donating 2 million international units (IUs) of ... WFH is an international not-for- profit organization which has ... and other inherited bleeding disorders. The donation supports the ...
Breaking Medicine Technology:Isis Reports Financial Results and Highlights for 2014 2Isis Reports Financial Results and Highlights for 2014 3Isis Reports Financial Results and Highlights for 2014 4Isis Reports Financial Results and Highlights for 2014 5Isis Reports Financial Results and Highlights for 2014 6Isis Reports Financial Results and Highlights for 2014 7Isis Reports Financial Results and Highlights for 2014 8Isis Reports Financial Results and Highlights for 2014 9Isis Reports Financial Results and Highlights for 2014 10Isis Reports Financial Results and Highlights for 2014 11Isis Reports Financial Results and Highlights for 2014 12Isis Reports Financial Results and Highlights for 2014 13Isis Reports Financial Results and Highlights for 2014 14Isis Reports Financial Results and Highlights for 2014 15Isis Reports Financial Results and Highlights for 2014 16Isis Reports Financial Results and Highlights for 2014 17Boston Scientific to Participate in the Barclays 2015 Annual Healthcare Conference 2CSL Behring Continues Treatment Access Leadership by Donating Bleeding Disorder Protein Therapies IUs to World Federation of Hemophilia 2CSL Behring Continues Treatment Access Leadership by Donating Bleeding Disorder Protein Therapies IUs to World Federation of Hemophilia 3
... 2011 AmbiCom Holdings, Inc. (OTCQB: ABHI), a leader in ... announced that it has signed a new line of credit ... that was due to expire July 2011. The new line ... $1.0 million in the previous revolving line and extends the ...
... Access Pharmaceuticals, Inc. ... proprietary drug-delivery platforms to develop treatments in areas of ... agreement with eMAX Health Systems to expand the distribution ... payer outreach programs for MuGard and advocate for reimbursement ...
Cached Medicine Technology:AmbiCom Renews and Expands Line of Credit With East West Bank 2AmbiCom Renews and Expands Line of Credit With East West Bank 3Access Pharmaceuticals Retains eMAX Health to Expand MuGard Distribution Network and Supplement Payer Outreach Programs 2Access Pharmaceuticals Retains eMAX Health to Expand MuGard Distribution Network and Supplement Payer Outreach Programs 3Access Pharmaceuticals Retains eMAX Health to Expand MuGard Distribution Network and Supplement Payer Outreach Programs 4
Shielding's Economy Coat Apron offers the same features as our Standard Coat Apron with an open back allowing for freedom of movement, maximum flexibility and increased comfort....
Lap pad used to protect pelvic regions...
The front of this apron is tapered for maximum adjustability as needed. We can include a specially designed half-apron to be worn under the full apron for double protection in the abdomen/pelvic cav...
... Our Back Relief Apron has ... transfers the weight from the ... the aid of a 6" ... be ordered to fit various ...
Medicine Products: