Navigation Links
UK researchers present findings from Kentucky breast cancer patients with disease relapse
Date:12/23/2011

LEXINGTON, Ky. (Dec. 23, 2011) The University of Kentucky Markey Cancer Center breast oncologist Dr. Suleiman Massarweh and his research team presented findings from their studies on relapse of breast cancer at the San Antonio Breast Cancer Symposium this month.

The two studies aimed to characterize further risk factors for presentation with metastatic disease or risk of early metastatic relapse after initial therapy. Data for each study was collected from 1,089 patients at the UK Markey Cancer Center between January 2007 and May 2011.

The studies showed that patients who present with metastatic disease in an initial diagnosis tend to be older, have lower grade tumors, a high frequency of estrogen receptor positive disease, and a predilection for bone metastasis. In contrast, patients who present with metastasis and early relapse after treatment tend to be younger and have more aggressive "triple negative" higher grade cancer that recurs despite appropriate therapy.

The findings suggest that initial presentation with metastatic disease is reflective of neglected breast cancer that is otherwise indolent, but patients chose to ignore it until they have no choice but to seek help. As a result, treatment then becomes more complex, more expensive and lifelong, with a major impact on quality of life and societal function.

Massarweh describes the neglect of metastatic disease as a social problem, an education issue and a matter of perception. Most women know they should get regular mammograms, he says, but widespread information on other facets of breast care like self-exams, symptoms, and second opinions are needed.

"The fear of a cancer diagnosis may drive patients to hide it from others, perhaps because they are more worried about the side effects of treatment and its impact on their lives," Massarweh said. "It's a shame that breast cancer, which is very otherwise treatable, ends up becoming incurable because of lack of awareness."

The kind of breast cancer that relapses early after therapy, within 2-3 years, reflects an aggressive resistant disease, despite appropriate therapy. In breast cancer with early relapse, Massarweh suggests that researchers should continue to test new therapeutic strategies to improve outcome.

"We clearly need to do more work and test novel therapy approaches to improve disease outcome, but also put major emphasis on increasing awareness about the importance of early detection and presentation when breast symptoms arise," Massarweh said. "In addition, it is very important that major cancer centers such as ours study their cancer populations more closely to identify characteristics of disease and guide the future of research and improving outcomes of patients."


'/>"/>

Contact: Allison Perry
allison.perry@uky.edu
859-323-2399
University of Kentucky
Source:Eurekalert

Related medicine news :

1. Pitt researchers propose new model to design better flu shots
2. UTHealth researchers link multiple sclerosis to different area of brain
3. Women should still be concerned about hormone replacement therapy, say McMaster researchers
4. Northwestern researchers trial new device that may support improved newborn health
5. More reasons to keep this New Years weight loss resolution uncovered by Ben-Gurion U researchers
6. Researchers identify potential target to delay metastatic pancreatic cancer and prolong survival
7. Researchers use light to measure cancer cells response to treatment
8. MDC researchers: Ion channel makes African naked mole-rat insensitive to acid-induced pain
9. MU researchers find pet kidney injuries are similar to human kidney injuries
10. UC Irvine researchers urge caution when buying noisy toys
11. Ohio State researchers discover hereditary predisposition of melanoma of the eye
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping ... fitness app. The fitness app plans to fix the two major problems leading the fitness ... size fits all type program , They don’t eliminate all the reasons people ...
(Date:6/25/2016)... , ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on ... Observer , brings up a new, often overlooked aspect of head lice: the parasite’s ability ... fumigation is not a common occurrence, but a necessary one in the event that lice ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a method ... —Johnson is one of the first doctors to perform the treatment. Orthobiologics are ...
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set ... drug or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, ... traumatic event. , Trauma sufferers tend to feel a range of emotions, from depression, ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, ... Elite. The attorneys chosen by their peers for this recognition are considered among the ... Traurig Shareholders received special honors as members of this year’s Legal Elite Hall of ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... , June 27, 2016  VMS Rehab Systems, Inc. ... will take whatever measures required to build a strong ... which is currently listed on the OTC Markets-pink current ... Chairman and CEO, "We are seeing an anomaly in ... understand, not only by the Company, but shareholders and ...
(Date:6/24/2016)... 24, 2016   Bay Area Lyme Foundation ... Dean Center for Tick Borne Illness , Harvard ... MIT Hacking Medicine, University of California, Berkeley, and ... the five finalists of Lyme Innovation , ... than 100 scientists, clinicians, researchers, entrepreneurs, and investors ...
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June 24, 2016 ... mobile pulmonary function testing company, is now able to perform sophisticated ... by ndd Medical Technologies , Inc. Patients ... hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ARL patients ... get any needed testing done in the comfort of her own ...
Breaking Medicine Technology: