Navigation Links
UK researchers present findings from Kentucky breast cancer patients with disease relapse
Date:12/23/2011

LEXINGTON, Ky. (Dec. 23, 2011) The University of Kentucky Markey Cancer Center breast oncologist Dr. Suleiman Massarweh and his research team presented findings from their studies on relapse of breast cancer at the San Antonio Breast Cancer Symposium this month.

The two studies aimed to characterize further risk factors for presentation with metastatic disease or risk of early metastatic relapse after initial therapy. Data for each study was collected from 1,089 patients at the UK Markey Cancer Center between January 2007 and May 2011.

The studies showed that patients who present with metastatic disease in an initial diagnosis tend to be older, have lower grade tumors, a high frequency of estrogen receptor positive disease, and a predilection for bone metastasis. In contrast, patients who present with metastasis and early relapse after treatment tend to be younger and have more aggressive "triple negative" higher grade cancer that recurs despite appropriate therapy.

The findings suggest that initial presentation with metastatic disease is reflective of neglected breast cancer that is otherwise indolent, but patients chose to ignore it until they have no choice but to seek help. As a result, treatment then becomes more complex, more expensive and lifelong, with a major impact on quality of life and societal function.

Massarweh describes the neglect of metastatic disease as a social problem, an education issue and a matter of perception. Most women know they should get regular mammograms, he says, but widespread information on other facets of breast care like self-exams, symptoms, and second opinions are needed.

"The fear of a cancer diagnosis may drive patients to hide it from others, perhaps because they are more worried about the side effects of treatment and its impact on their lives," Massarweh said. "It's a shame that breast cancer, which is very otherwise treatable, ends up becoming incurable because of lack of awareness."

The kind of breast cancer that relapses early after therapy, within 2-3 years, reflects an aggressive resistant disease, despite appropriate therapy. In breast cancer with early relapse, Massarweh suggests that researchers should continue to test new therapeutic strategies to improve outcome.

"We clearly need to do more work and test novel therapy approaches to improve disease outcome, but also put major emphasis on increasing awareness about the importance of early detection and presentation when breast symptoms arise," Massarweh said. "In addition, it is very important that major cancer centers such as ours study their cancer populations more closely to identify characteristics of disease and guide the future of research and improving outcomes of patients."


'/>"/>

Contact: Allison Perry
allison.perry@uky.edu
859-323-2399
University of Kentucky
Source:Eurekalert

Related medicine news :

1. Pitt researchers propose new model to design better flu shots
2. UTHealth researchers link multiple sclerosis to different area of brain
3. Women should still be concerned about hormone replacement therapy, say McMaster researchers
4. Northwestern researchers trial new device that may support improved newborn health
5. More reasons to keep this New Years weight loss resolution uncovered by Ben-Gurion U researchers
6. Researchers identify potential target to delay metastatic pancreatic cancer and prolong survival
7. Researchers use light to measure cancer cells response to treatment
8. MDC researchers: Ion channel makes African naked mole-rat insensitive to acid-induced pain
9. MU researchers find pet kidney injuries are similar to human kidney injuries
10. UC Irvine researchers urge caution when buying noisy toys
11. Ohio State researchers discover hereditary predisposition of melanoma of the eye
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... La Puente, California (PRWEB) , ... February 09, ... ... Dental Medicine students, faculty and staff helped give free oral screenings to 150 ... California Feb. 5, 2016. , The College of Dental Medicine joined Chinese American ...
(Date:2/9/2016)... Fort Lauderdale, Florida (PRWEB) , ... February 09, 2016 , ... ... known as the Taste of South Florida Event, an upscale fundraiser held in South ... to wow sponsors and guests alike. This year the event will be held in ...
(Date:2/9/2016)... ... February 09, 2016 , ... A new study ... rates and Medicare rates for a variety of medical services in Illinois as ... of the 2015 Fee Schedule Rates in Illinois, are professional medical services, ...
(Date:2/9/2016)... ... , ... On January 12, 2016 Paul McElwee, a CroppMetcalfe HVAC technician, visited ... not producing any heat. Shortly after entering the home, Paul was able to identify ... levels of carbon monoxide into the home, at 2,000 parts per million in the ...
(Date:2/9/2016)... , ... February 09, 2016 , ... ... The guide will ensure lab personnel have a basic understanding of the techniques ... measurement protocols. Enhanced understanding will help them reduce waste and rework to create ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... , Feb. 9, 2016 On ... Administration (FDA) met with its Arthritis Advisory ... biosimilar of Johnson & Johnson,s Remicade and ... approved in the U.S. The Biologics Prescribers ... groups - Alliance for Patient Access, American ...
(Date:2/10/2016)... February 10, 2016 Demonstrates ... 1 receptor selectivity   1 ... which has entered clinical development as a new ... and schizophrenia.   --> 1 ... has entered clinical development as a new treatment ...
(Date:2/9/2016)... 9, 2016  Insulet Corporation (NASDAQ: PODD ) (Insulet ... technology with its OmniPod ® Insulin ... has been appointed to Insulet,s Board of Directors. With his ... of whom are independent. --> ... and finance experience and a deep knowledge of accounting, financial ...
Breaking Medicine Technology: