Navigation Links
UIC researchers discover how cells limit inflammation in lung injury
Date:12/15/2011

Researchers at the University of Illinois at Chicago College of Medicine have found in an animal model of acute lung injury a molecular mechanism that allows cells of the immune system to reduce tissue damage from inflammation.

The study is reported in Nature.

Inflammation is part of the normal response to infection. One aspect of inflammation is the production of negatively charged oxygen-rich molecules by specialized white blood cells called phagocytes. The molecules, called reactive oxygen species (ROS), help to break up bacteria, allowing the phagocytes to "mop up" the broken pieces and clear out the infection. Unfortunately, ROS can also cause damage to normal tissue.

The UIC researchers found that a channel through the cell membrane of phagocytes is able to modulate this destructive phase of inflammation.

"Although the channel, called TRPM2, is found in many cell types in the immune system, including phagocytes, it's function in these cells has been unknown," said Anke Di, UIC research assistant professor in pharmacology and first author of the study.

The researchers were able to show that TRPM2 had a protective anti-inflammatory role in the animal model of ALI, and, further, it played a previously unknown role in protecting against inflammation and tissue injury generally.

TRPM2's protective effect was a result of its ability to dampen the production of the negatively charged ROS by modulating the electrochemical gradient -- the difference in charge between molecules within the cell and outside the plasma membrane of the cell.

ALI and its more severe form, acute respiratory distress syndrome (ARDS) result from pulmonary edema (leaky blood vessels) and inflammation. Both direct lung injury from infection and indirect lung injury from trauma, sepsis, pancreatitis, transfusions, radiation exposure and drug overdose can trigger ALI. It is fatal in almost 40 percent of cases.

Infla
'/>"/>

Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2015)... April 25, 2015 Gardant Management ... wellness, management and operations, and sales and marketing ... Exhibition scheduled to be held from April 29 ... Illinois is the largest eldercare association in Illinois. ... services for older adults, including senior housing, assisted ...
(Date:4/25/2015)... Minneapolis, Minnesota (PRWEB) April 25, 2015 For ... as the premier income protection education event in the nation! ... up with The Plus Group, US to take DI Day ... Day. , George G. Davidson, CLU, ChFC, RHU, DIA, CLTC, ... Twin Cities DI Day reflects on the change by stating, ...
(Date:4/24/2015)... 2015 Ryadon is a leading manufacturer ... capabilities and services to complement any custom hardware requirements ... Program will be offered on all heavy duty drawer ... Receive 10% discount - Order 20+: Receive 20% discount ... Slides Products, Furniture ,Drawer ...
(Date:4/24/2015)... CA (PRWEB) April 24, 2015 On ... sitting down in an interview with ItsNotAboutMe.TV contributor Karen ... Recovery, a holistic treatment center for addiction, of which ... ceremonies and festivals throughout the year, the EcoLuxe Lounge ... providers of eco-friendly and socially conscious products and services. ...
(Date:4/24/2015)... Integrative Therapeutics has introduced two new ... cognition. , A unique combination of herbs and ... Flavonoid Complex apart from other antioxidant supplements. This ... support antioxidation versus the use of single or ... extract, Resveratrol, Alpha-Glycosyl Isoquercitrin, and Coenzyme Q10 with ...
Breaking Medicine News(10 mins):Health News:Gardant Management Solutions Staff Shares Operational Expertise 2Health News:Secura Consultants Takes DI Day On The Road 2Health News:Ryadon Inc. Offers Quantity Drawer Slide Discount Program Nationwide in May 2015 2Health News:Ryadon Inc. Offers Quantity Drawer Slide Discount Program Nationwide in May 2015 3Health News:Karen Salkin Talks with Per Wickstrom at the 2015 EcoLuxe Lounge and the "Salute to the Oscars" Celebration 2Health News:Integrative Therapeutics Introduces Two ProThrivers™ Wellness Supplements with Specialty Ingredients from Kyowa Hakko USA 2Health News:Integrative Therapeutics Introduces Two ProThrivers™ Wellness Supplements with Specialty Ingredients from Kyowa Hakko USA 3Health News:Integrative Therapeutics Introduces Two ProThrivers™ Wellness Supplements with Specialty Ingredients from Kyowa Hakko USA 4
... 9 Volcano Corporation,(Nasdaq: VOLC ) announced today ... the third quarter ended September 30, 2007.,The company said ... increase in the sales of its Intravascular Ultrasound (IVUS),disposables ... of,24 percent in sales of IVUS disposables versus the ...
... COLORADO SPRINGS, Colo., Oct. 9 Spectranetics,Corporation (Nasdaq: ... reimbursement,approval from the competent governmental authority in Belgium ... effective October 1, 2007. The reimbursement for ... or an electronic malfunction of a pacemaker or ...
... Natural Nutrition,(OTC Bulletin Board: NNTN) http://www.interactivenutrition.com ... 11, 2007 at,11:00 a.m. Eastern time. U.S. and ... at 800-750-4065 and International Shareholders may dial in ... is 767872#. Executives,from Natural Nutrition will be available ...
... 9 Endocare, Inc. (OTC,Bulletin Board: ECRE), an ... minimally invasive technologies for tissue and tumor,ablation, announced ... on NASDAQ.,The Company,s common stock will commence trading ... beginning tomorrow, October 10, 2007. Craig T. ...
... Oct. 9 Volcano Corporation,(Nasdaq: VOLC ) announced ... to,market and other conditions, 6,000,000 shares of newly issued ... filed,with the Securities and Exchange Commission. The Company intends ... to an additional 900,000,shares of common stock. J.P. ...
... ... reform, DES MOINES, Iowa, Oct. 9 ... weighed in on a,critical 2008 campaign issue: health care. According to a survey ... current health care system is broken-and they don,t trust,politicians to fix it. ...
Cached Medicine News:Health News:Volcano Corporation Reports Preliminary Third Quarter 2007 Revenues 2Health News:Spectranetics Receives Reimbursement Approval in Belgium for Lead Removal and Peripheral Atherectomy Products 2Health News:Spectranetics Receives Reimbursement Approval in Belgium for Lead Removal and Peripheral Atherectomy Products 3Health News:Natural Nutrition to Hold International Shareholder Conference Call Thursday, October 11, 2007 at 11:00 a.m. Eastern Time 2Health News:Endocare Stock to Commence Trading on NASDAQ 2Health News:Volcano Corporation Announces Proposed Public Offering of Common Stock 2Health News:Survey of Iowa Voters Reveals Surprising Results and Attitudes Toward America's Health Care Crisis 2Health News:Survey of Iowa Voters Reveals Surprising Results and Attitudes Toward America's Health Care Crisis 3Health News:Survey of Iowa Voters Reveals Surprising Results and Attitudes Toward America's Health Care Crisis 4
(Date:4/24/2015)... 24, 2015   Bernstein Liebhard LLP ... or the "Company") (NASDAQ: AERI ) issued ... violation of the federal securities laws; or (ii) ... fiduciary duties to shareholders. Aerie is ... development and commercialization of first-in-class therapies for the ...
(Date:4/24/2015)... April 24, 2015 Allowing more basic emergency ... drug overdose deaths that involve opioids, according to a ... in Naloxone Administration by Emergency Medical Service Providers and ... in the American Journal of Public Health . ... the United States involved prescription ...
(Date:4/24/2015)... April 24, 2015  A new study shows an "alarming ... drugs used to slow the progression of multiple sclerosis or ... by researchers at Oregon Health & Science University (OHSU) and ... the number of MS drugs in the marketplace over the ... stabilized costs for patients who use those drugs. Researchers found ...
Breaking Medicine Technology:Bernstein Liebhard LLP Investigates Claims On Behalf Of Those Who Invested In Aerie Pharmaceuticals, Inc. 2Expanding Naloxone use could reduce drug overdose deaths and save lives 2Expanding Naloxone use could reduce drug overdose deaths and save lives 3Researchers find alarming rise in cost of MS drugs over past two decades 2Researchers find alarming rise in cost of MS drugs over past two decades 3Researchers find alarming rise in cost of MS drugs over past two decades 4
... 2007 - BioLineRx Ltd.,(TASE:BLRX), Israel's leading drug ... I trial of BL-1020, the first GABA,enhanced ... The trial demonstrated that the compound was ... which is indicative of efficacy. BioLineRx presented ...
... -- Auxilium,Pharmaceuticals, Inc. today announced that new ... energy levels and,erectile function in 76 percent ... replacement gel therapy. Total testosterone,levels increased significantly ... (testosterone gel) following suboptimal,response to Solvay S.A.'s ...
Cached Medicine Technology:BioLineRx Presents Data From Successful Phase I Trial for BL-1020,in Schizophrenia at American Psychiatric Association Conference 2BioLineRx Presents Data From Successful Phase I Trial for BL-1020,in Schizophrenia at American Psychiatric Association Conference 3BioLineRx Presents Data From Successful Phase I Trial for BL-1020,in Schizophrenia at American Psychiatric Association Conference 4Auxilium Announces New Data That Show Total Testosterone Blood,Levels Increase Significantly Following Switch from AndroGel(R) to,Testim(R) 2Auxilium Announces New Data That Show Total Testosterone Blood,Levels Increase Significantly Following Switch from AndroGel(R) to,Testim(R) 3Auxilium Announces New Data That Show Total Testosterone Blood,Levels Increase Significantly Following Switch from AndroGel(R) to,Testim(R) 4Auxilium Announces New Data That Show Total Testosterone Blood,Levels Increase Significantly Following Switch from AndroGel(R) to,Testim(R) 5
Conventional Digitally-Controlled Water Baths...
Conventional Digitally-Controlled Water Baths...
... a flexible, self-expanding nitinol design intended to ... biliary system, is now available from Cook ... and Drug Administration. Incorporating the features that ... successful around the world, the Zilver 518 ...
... The AB5000 Circulatory Support System consists of ... advanced computer system that drives the blood pumps ... or for transport of patients between hospitals. The ... of supporting the left, right, or both ventricles ...
Medicine Products: