Navigation Links
UIC researchers discover how cells limit inflammation in lung injury

Researchers at the University of Illinois at Chicago College of Medicine have found in an animal model of acute lung injury a molecular mechanism that allows cells of the immune system to reduce tissue damage from inflammation.

The study is reported in Nature.

Inflammation is part of the normal response to infection. One aspect of inflammation is the production of negatively charged oxygen-rich molecules by specialized white blood cells called phagocytes. The molecules, called reactive oxygen species (ROS), help to break up bacteria, allowing the phagocytes to "mop up" the broken pieces and clear out the infection. Unfortunately, ROS can also cause damage to normal tissue.

The UIC researchers found that a channel through the cell membrane of phagocytes is able to modulate this destructive phase of inflammation.

"Although the channel, called TRPM2, is found in many cell types in the immune system, including phagocytes, it's function in these cells has been unknown," said Anke Di, UIC research assistant professor in pharmacology and first author of the study.

The researchers were able to show that TRPM2 had a protective anti-inflammatory role in the animal model of ALI, and, further, it played a previously unknown role in protecting against inflammation and tissue injury generally.

TRPM2's protective effect was a result of its ability to dampen the production of the negatively charged ROS by modulating the electrochemical gradient -- the difference in charge between molecules within the cell and outside the plasma membrane of the cell.

ALI and its more severe form, acute respiratory distress syndrome (ARDS) result from pulmonary edema (leaky blood vessels) and inflammation. Both direct lung injury from infection and indirect lung injury from trauma, sepsis, pancreatitis, transfusions, radiation exposure and drug overdose can trigger ALI. It is fatal in almost 40 percent of cases.

Inflammation plays an important role in ALI and a number of other human diseases, said Dr. Asrar Malik, UIC Schweppe Family Distinguished Professor and head of pharmacology and principal investigator of the study. Understanding how inflammatory damage to tissues is controlled normally may help develop therapies in the future, he said.


Contact: Jeanne Galatzer-Levy
University of Illinois at Chicago

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
(Date:10/13/2015)... , ... October 13, 2015 , ... Local Gold’s Gym ... Gym International Conference on August 26. Berry, who owns and operates Gold's Gym ... the fastest growing Gold’s Gyms in the United States. A brand leader in global ...
(Date:10/13/2015)... ... October 13, 2015 , ... Breathing is one of the ... correctly. According to T’ai Chi (also spelled “Taiji”) and Qigong Grand-masters Steven Aung, ... concert with the 7,000 year old tradition they teach, can improve health, increase ...
(Date:10/13/2015)... ... ... With Fall weather approaching and holiday travel season upon us, is giving away ... to win! , How to Enter:, 1. Like on Facebook , 2. ... us on Instagram @thebeautyplace , 4. Share Facebook Contest Image With Friends , ...
(Date:10/13/2015)... DALLAS, Texas (PRWEB) , ... October 13, 2015 ... ... comprehensive treatment possible for children with autism, PediaPlex , a Southlake, Texas, ... value of ABA Therapy and educating military families about their options ...
(Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... ... sustainable and eco-friendly home furnishings and décor, today announced it closed on a ... investor. The funds will be used to support the Company’s continued rapid growth ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... MUNICH , October 13, 2015 ... --> World Thrombosis Day Interactive Infographic   ... World Thrombosis Day  to promote vital ... and signs and symptoms. Thrombosis is the formation ... (venous thrombosis) - resulting in venous thromboembolism (VTE) ...
(Date:10/13/2015)... PARK, Calif. , Oct. 13, 2015 /PRNewswire/ ... an agreement with the UK-based Cell Therapy Catapult ... for AST-VAC2, Asterias, allogeneic dendritic cell immunotherapy. Under ... and scale manufacturing processes for AST-VAC2 to support ... --> --> ...
(Date:10/12/2015)... -- Given the intricacy of the anatomy and ... an ophthalmic drug effectively to a specific ocular site. Several ... delivery. These include dilution of a drug by tears, clearance ... drug permeation issues with respect to the cornea, sclera and ... is lost due to the aforementioned barriers. --> ...
Breaking Medicine Technology: