Navigation Links
UIC researcher unveils new approach to blocking malaria transmission
Date:12/4/2010

University of Illinois at Chicago researcher Dr. John Quigley will describe a promising new approach to blocking malaria transmission during the American Society of Hematology's annual meeting in Orlando, Fla.

Quigley will speak at a press briefing Saturday, Dec. 4, at 8 a.m. at the Orange County Convention Center, 9800 International Drive, Room 208C (West Building). His abstract, "Anopheline Orthologs of the Human Erythroid Heme Exporter, FLVCR, Export Heme: Potential Targets to Inhibit Plasmodium Transmission," will be presented at the plenary session Sunday.

The research focuses on potential targets to inhibit transmission of the parasite Plasmodium that causes malaria.

Female mosquitoes ingest large amounts of hemoglobin that serves as a food source required for mosquito egg development. When a mosquito ingests infected blood, Plasmodium reproduces in the mosquito gut. Plasmodium fertilized egg cells cross the lining of the mosquito gut and develop into oocysts. After maturing, the oocysts rupture and release thousands of parasites that allow the mosquito to transmit malaria when it bites another human.

Previous studies have shown that mosquitoes with increased oxidative stress in their midgut are resistant to Plasmodium transmission. Quigley and his colleagues hypothesize that if they can disrupt the function of a cell-surface transport protein called FLVCR that pumps heme out of the cell, it will increase the oxidative stress in the mosquito gut and hamper Plasmodium at a crucial point in the parasite's life cycle.

The researchers isolated the FLVCR gene from two common malaria-transmitting mosquitoes and showed that the gene encodes a protein that exports heme and protects cells from oxidative stress. Using gene-silencing techniques, they were able to significantly reduce levels of FLVCR in the mosquito gut.

"If disruption of the function of the protein inhibits parasite transmission, then we can pote
'/>"/>

Contact: Sherri McGinnis Gonzlez
smcginn@uic.edu
312-996-8277
University of Illinois at Chicago
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New clue in leukemia mystery: Researchers identify poison employed by deadly enzyme mutations
2. Less is more, when it comes to sugary, high-caffeine energy drinks, researchers say
3. University of Utah and Harvard researchers take major step toward first biological test for autism
4. BUSM researchers show an oncolytic virus switches off cancer cell survival signal
5. Researchers use patients own blood to treat hamstring injury
6. Sporadic breast cancers start with ineffective DNA repair systems, Pitt researchers find
7. Researchers identify a molecular switch that controls neuronal migration in the developing brain
8. UCLA researchers discover drug resistance mechanisms in most common form of melanoma
9. Researchers shine light on how some melanoma tumors evade drug treatment
10. New function of gene in promoting cancer found by VCU researchers
11. Stanford researchers first to turn normal cells into 3-D cancers in tissue culture dishes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2014)... NY (PRWEB) September 20, 2014 Ticket ... Grande concert tickets. This popular ticket exchange is ... , Ariana Grande is nearing that next step in the ... considered a superstar in the music and entertainment business, but ... released her second straight No. 1 album, will hit the ...
(Date:9/20/2014)... The print component of “Work-Life Balance” is being ... with a circulation of approximately 97,000 copies and ... is distributed nationally through a vast social media ... sites and partner outlets. To explore the digital ... , The publication features an exclusive Mediaplanet interview ...
(Date:9/20/2014)... -- As flu season approaches, the best way to ... flu shot and a checkup, according to an infectious ... vaccinate people against the flu, and also address other ... may provide flu shots for their customers, but they ... medical director of infection prevention and control for the ...
(Date:9/20/2014)... 2014 New PharmaPoint Drug Evaluation ... to 2023?. The asthma market saw very slow ... become saturated with relatively efficacious standard therapies, such ... corticosteroids and long-acting beta-agonists (ICS/LABAs), and leukotriene modifiers, ... However, the launch of seven novel targeted biologic ...
(Date:9/20/2014)... Recently, Best Cheap Hosting USA ... its new website. The new site provides the ... products for customers. Here, people can find a ... decision. Also, it has recommended some excellent web ... of the great web hosting suppliers, InMotion ( ...
Breaking Medicine News(10 mins):Health News:Ariana Grande Tickets in Chicago/Rosemont, Kansas City, Milwaukee, Saint Paul, Dallas, Houston, San Antonio, Oklahoma City Go On Sale Today 2Health News:Ariana Grande Tickets in Chicago/Rosemont, Kansas City, Milwaukee, Saint Paul, Dallas, Houston, San Antonio, Oklahoma City Go On Sale Today 3Health News:Getting ‘Wellthy’: Mediaplanet’s “Work-Life Wellness” campaign puts stock in the personal and economic gains of healthy, vital workplace environments for Canadians 2Health News:Get a Flu Shot During Checkup, Doctor Says 2Health News:Symbicort Asthma Market Forecasts to 2023 - Overview, Efficacy, Safety & SWOT Analysis in New Report Available at LifeScienceIndustryResearch.com 2Health News:Symbicort Asthma Market Forecasts to 2023 - Overview, Efficacy, Safety & SWOT Analysis in New Report Available at LifeScienceIndustryResearch.com 3Health News:Symbicort Asthma Market Forecasts to 2023 - Overview, Efficacy, Safety & SWOT Analysis in New Report Available at LifeScienceIndustryResearch.com 4Health News:Best Cheap Hosting USA Launches Its New Website And Recommends InMotion To Worldwide People 2
... fluid in the ears does not improve speech, hearing or ... two reasons for ear tube surgery -- persistent, severe ear ... otherwise healthy child. Doctors have been concerned that if surgery ... long-term developmental impairment. ,"We were led to the conclusion ...
... companies to drop a historic case in South Africa ... according to leading non-governmental organizations (NGOs). ,The 39 ... legalized use and import of generic medicines free from ... biggest in the world, had challenged the order on ...
... Researchers in the UK say that wound healing in depressed ... These and related reports find a place in the latest ... have direct and indirect effects on the rate of wound ... have been shown to affect the immune system, which may ...
... J. Keefe of Duke University Medical School in Durham, North ... of the Journal of pain. Patients who use religion or ... can reduce their pain and boost their sense of well ... expect that people coping with chronic illness or chronic pain ...
... exercising reduces the risk of heart disease. But almost everyone ... But recent study shows that skinny people are also prone ... important factors in the genesis of various heart ailments. ... Canada, who headed the study, says that heart disease does ...
... which was developed to fight resistant bacteria, is already ... resistance. ,The drug linezolid is used to treat ... the old standby antibiotic vancomycin. The hope has been ... problem of vancomycin-resistant enterococci infections. But in the April ...
Cached Medicine News:Health News:Researchers urge caution in using ear tube surgery 2Health News:Researchers urge caution in using ear tube surgery 3Health News:India to benefit from pharma companies' move 2
(Date:9/19/2014)... , September 19, 2014 ... by Equipment Type (Benchtop, Mobile, Industrial, & Laboratory), ... Technology (Tray-style, Manifold, & Rotary) & Geography - ... MarketsandMarkets, defines and segments the lyophilization market on ... with analyses and projections of the market size ...
(Date:9/19/2014)... and ORLANDO, Fla. , ... supporting Inspire therapy continues to grow, with the publication ... published on-line in Otolaryngology – Head and ... causes a worsening of both objective and subjective measures ... directly attribute Inspire therapy for the reduction in obstructive ...
(Date:9/19/2014)... BALTIMORE and CAMBRIDGE, Mass. ... Diagnostics Inc. (PGDx), a provider of advanced ... Blueprint Medicines , a leader in discovering and ... cancers, today disclosed the first-ever comprehensive genomic study ... and deadly cancer of the female reproductive system, ...
Breaking Medicine Technology:Lyophilization Market Worth $5,121.5 Million by 2019 2Lyophilization Market Worth $5,121.5 Million by 2019 3New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 2New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 3New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 4First Discovery Of Actionable Genetic Alterations In A Deadly Cancer Reported By Personal Genome Diagnostics And Blueprint Medicines 2First Discovery Of Actionable Genetic Alterations In A Deadly Cancer Reported By Personal Genome Diagnostics And Blueprint Medicines 3First Discovery Of Actionable Genetic Alterations In A Deadly Cancer Reported By Personal Genome Diagnostics And Blueprint Medicines 4
... (Nasdaq: VRUS ) announced today the pricing ... its common stock at an offering price of $46.33 ... selling 2,300,000 shares and the selling stockholders are selling ... deducting the underwriting discount and estimated offering expenses, of ...
... investor meeting held today in New York, NY, Watson ... update on its Global businesses, including a detailed overview ... Global Generics and Global Brands businesses, and an update ... the meeting, the Company provided its preliminary 2011 financial ...
Cached Medicine Technology:Pharmasset Prices Public Offering of Common Stock 2Pharmasset Prices Public Offering of Common Stock 3Watson Presents Outlook for Continued Long Term Growth 2Watson Presents Outlook for Continued Long Term Growth 3Watson Presents Outlook for Continued Long Term Growth 4Watson Presents Outlook for Continued Long Term Growth 5Watson Presents Outlook for Continued Long Term Growth 6Watson Presents Outlook for Continued Long Term Growth 7Watson Presents Outlook for Continued Long Term Growth 8
Delicate membrane hook/pick with hook on side of instrument for engaging membranes. 20 gauge shaft with balanced titanium handle. Dark finish for reduced glare. Left....
0.5 mm angled tip. Round knurled handle with dull finish. Tip angle: 150 degrees....
0.2 mm, 90o angled tip. Flat smooth handle with polished finish....
Nucleus manipulator facilitates lens rotation during phacoemulsification....
Medicine Products: