Navigation Links
UIC researcher unveils new approach to blocking malaria transmission
Date:12/4/2010

University of Illinois at Chicago researcher Dr. John Quigley will describe a promising new approach to blocking malaria transmission during the American Society of Hematology's annual meeting in Orlando, Fla.

Quigley will speak at a press briefing Saturday, Dec. 4, at 8 a.m. at the Orange County Convention Center, 9800 International Drive, Room 208C (West Building). His abstract, "Anopheline Orthologs of the Human Erythroid Heme Exporter, FLVCR, Export Heme: Potential Targets to Inhibit Plasmodium Transmission," will be presented at the plenary session Sunday.

The research focuses on potential targets to inhibit transmission of the parasite Plasmodium that causes malaria.

Female mosquitoes ingest large amounts of hemoglobin that serves as a food source required for mosquito egg development. When a mosquito ingests infected blood, Plasmodium reproduces in the mosquito gut. Plasmodium fertilized egg cells cross the lining of the mosquito gut and develop into oocysts. After maturing, the oocysts rupture and release thousands of parasites that allow the mosquito to transmit malaria when it bites another human.

Previous studies have shown that mosquitoes with increased oxidative stress in their midgut are resistant to Plasmodium transmission. Quigley and his colleagues hypothesize that if they can disrupt the function of a cell-surface transport protein called FLVCR that pumps heme out of the cell, it will increase the oxidative stress in the mosquito gut and hamper Plasmodium at a crucial point in the parasite's life cycle.

The researchers isolated the FLVCR gene from two common malaria-transmitting mosquitoes and showed that the gene encodes a protein that exports heme and protects cells from oxidative stress. Using gene-silencing techniques, they were able to significantly reduce levels of FLVCR in the mosquito gut.

"If disruption of the function of the protein inhibits parasite transmission, then we can potentially use parts of the protein as an antigen to try to stimulate a vaccine in people," said Quigley, who is assistant professor of medicine at the UIC College of Medicine and senior author of the study. "So the antibody blocks FLVCR and increases oxidative stress, and now the Plasmodium is not able to complete its life cycle, thus preventing the spread of malaria."

Quigley's research is ongoing, and future studies will focus on whether inhibiting FLVCR can block Plasmodium transmission. The research, he says, may be applicable to all blood-eating insects that cause a variety of diseases, such as West Nile Virus, dengue fever and leishmaniasis.


'/>"/>

Contact: Sherri McGinnis Gonzlez
smcginn@uic.edu
312-996-8277
University of Illinois at Chicago
Source:Eurekalert

Related medicine news :

1. New clue in leukemia mystery: Researchers identify poison employed by deadly enzyme mutations
2. Less is more, when it comes to sugary, high-caffeine energy drinks, researchers say
3. University of Utah and Harvard researchers take major step toward first biological test for autism
4. BUSM researchers show an oncolytic virus switches off cancer cell survival signal
5. Researchers use patients own blood to treat hamstring injury
6. Sporadic breast cancers start with ineffective DNA repair systems, Pitt researchers find
7. Researchers identify a molecular switch that controls neuronal migration in the developing brain
8. UCLA researchers discover drug resistance mechanisms in most common form of melanoma
9. Researchers shine light on how some melanoma tumors evade drug treatment
10. New function of gene in promoting cancer found by VCU researchers
11. Stanford researchers first to turn normal cells into 3-D cancers in tissue culture dishes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2017)... , ... March 27, 2017 , ... ... quickly sideline athletes. A type of groin injury, it occurs when the muscles ... serious, intense pain in and around the lower torso, as well as accompanying ...
(Date:3/27/2017)... ... 2017 , ... Advantexe Learning Solutions , a global ... new research study, The Business Readiness Report. The report explores the correlation between ... actual success of achieving individual and company goals. , There are many ...
(Date:3/27/2017)... , ... March 27, 2017 , ... ... that for a second year in a row; they are the recipient of ... in the industry voted on the award at Design Connections 2017. Top A&D ...
(Date:3/27/2017)... San Mateo, CA (PRWEB) , ... March 27, 2017 , ... Janet Schloz is still ... one of the best days I’ve had in a long time,” she said. , She ... a lot of money that I never thought I would have to help my students.” ...
(Date:3/27/2017)... ... 2017 , ... The Anaheim Hills office accelerates and supports FNCC’s growth and ... new sales professionals over the past 6 months and is continuing to recruit new ... the course of 2017. , “This new office is a direct result of ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... N.J. , March 27, 2017 Invivotek, ... and leading in vivo pharmacology contract research ... Farm adjacent to its newly expanded preclinical research facility ... solar farm provides a cleaner, renewable energy source to ... the environment. Completion of the Genesis Solar Farm follows ...
(Date:3/24/2017)... PUNE, India , March 24, 2017 Abdominal Aortic ... reach $2,614 million by 2022, Globally, registering a CAGR of 5.1% from 2016 to ... and is projected to dominate the market during the study period. ... ... ...
(Date:3/24/2017)... 24, 2017 New England Pediatric Device Consortium ... award including funding and in-kind service towards the commercialization ... "Making blood draws less traumatic for children ... hospital experience better.  We,re looking forward to working with ... improve care for the kids we treat," said ...
Breaking Medicine Technology: