Navigation Links
UIC receives $3 million to study prostate cancer risk factors
Date:2/27/2009

Researchers at the University of Illinois at Chicago's Institute for Health Research and Policy have been awarded a five-year, $3 million grant from the National Cancer Institute to study the link between body fat and prostate cancer progression.

Recent studies have found that obese men with prostate cancer have a higher likelihood of developing progressive or fatal disease regardless of their tumor grade and stage at diagnosis.

The UIC researchers plan to identify the biological factors responsible for poorer outcomes among obese patients, says Dr. Vincent Freeman, assistant professor of epidemiology at the UIC School of Public Health and principal investigator of the project.

The findings should lead to new approaches to preventing prostate cancer recurrence or progression after treatment that could involve drug therapies, lifestyle changes, or both, Freeman said.

Freeman's team will enroll approximately 500 men from Chicago-area medical centers who have been diagnosed with clinically early-stage prostate cancer and who are candidates for curative therapy with surgery.

Body fat will be quantified at the time of diagnosis and one year after surgery using standard body-size measurements such as waist circumference and body mass index, and body composition measurements using X-rays to measure the relative amounts of bone, body water, and body fat.

Data will also be collected for the patient's body-weight history, diet, physical activity level, general health and socio-demographic background.

At the time of surgery, the researchers will also collect prostate tissue and fat tissue from the region of the prostate gland for a series of biochemical and molecular studies, Freeman said. They will measure fatty acids and their metabolites; the activity of a signaling pathway called the insulin-like growth factor axis; inflammatory factors that are produced by fat cells; and metabolites of male hormones. The tests "will determine whether the activity of certain metabolic pathways explains the association between body fatness and prostate cancer recurrence," Freeman said.

Patients will be followed for two years with periodic measurements of prostate-specific antigen, a protein produced by the prostate gland. Those with prostate cancer recurrence will be identified by an increasing PSA. Typically, the PSA should remain in an undetectable range following surgery for prostate cancer.


'/>"/>

Contact: Sherri McGinnis Gonzalez
smcginn@uic.edu
312-996-8277
University of Illinois at Chicago
Source:Eurekalert

Related medicine news :

1. Winner Medical Receives European Patent Office Approval for PurCotton(TM) Production Method
2. Virtua Health Receives Approval from NJHCFFA to Sell Tax-Exempt Bonds
3. Blair C. Filler, M.D. Receives 2009 Tipton Award for Outstanding Orthopaedic Leadership
4. Angiotech receives approval for Quill(TM) SRS PDO, MONODERM(TM) and Nylon product lines for sale in Canada
5. Solos Endoscopy, Inc. Receives Purchase Order from Major Connecticut Hospital for the MammoView(TM)
6. Boston University School of Medicine receives grant
7. Mylans Matrix Receives WHO Approval for First Generic, Heat-Stable Version of HIV Protease Inhibitor
8. Pharmacyclics Receives Nasdaq Notification
9. ING Run For Something Better Receives Healthy Youth for a Healthy Future Champion Award
10. International Partnership for Microbicides Receives US $130 Million from UK Government and the Gates Foundation
11. Industry Leading Data Quality and Householding Software Receives New Functionality for Enhanced Performance and Speed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2017)... ... May 23, 2017 , ... i2i Population Health, ... in KLAS category winner, has named Daniel P. Bullington as chief technology officer. ... technology platform and product offerings,” says Justin Neece, president. “Daniel is an excellent ...
(Date:5/23/2017)... CA (PRWEB) , ... May 23, 2017 , ... By ... season underway in Sonoma County. While officials call for diligence, asking homeowners to scout ... looking at potential health concerns. Along with the annoying buzz of mosquitos is the ...
(Date:5/23/2017)... ... ... New patients from Charleston, SC, are now welcome to receive a full ... with or without a referral. A full mouth reconstruction can transform the appearance of ... Charleston, SC. Those who suffer from gum disease, misaligned teeth or jaw pain can ...
(Date:5/23/2017)... ... May 23, 2017 , ... Therachat , a smart ... in an infographic on the current state of anxiety in support of National Mental ... was conducted in April 2017 and benchmarked general anxiety levels as well as identified ...
(Date:5/22/2017)... ... May 22, 2017 , ... Dr. Kiya Green, ... with periodontal plastic surgery treatments, including crown lengthening and gum reduction ... these esthetic and functional procedures to help patients improve their oral health, reduce ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... MARLBOROUGH, Mass., May 10, 2017 Hologic, Inc. ... financial results for the fiscal second quarter ended April ... (EPS) of $1.84 increased 666.7% compared to the prior ... business resulted in a significant gain, while non-GAAP diluted ... increased 3.2%, or 3.8% in constant currency terms.  Excluding ...
(Date:5/10/2017)... May 10, 2017 Radiology has become the ... costs have also spiraled to the number one ranking ... radiology than ever before as the most complete and ... patient with lower back pain an MRI may confirm ... for pain, resulting in entirely different treatment protocols.  In ...
(Date:5/9/2017)... WASHINGTON , May 9, 2017  Demonstrating ... the board of directors for the Pharmaceutical Research ... criteria for membership. Biopharmaceutical companies will now have ... in order to be eligible to join PhRMA. ... criteria, the board is sending a clear message ...
Breaking Medicine Technology: