Navigation Links
UIC receives $3 million to study prostate cancer risk factors
Date:2/27/2009

Researchers at the University of Illinois at Chicago's Institute for Health Research and Policy have been awarded a five-year, $3 million grant from the National Cancer Institute to study the link between body fat and prostate cancer progression.

Recent studies have found that obese men with prostate cancer have a higher likelihood of developing progressive or fatal disease regardless of their tumor grade and stage at diagnosis.

The UIC researchers plan to identify the biological factors responsible for poorer outcomes among obese patients, says Dr. Vincent Freeman, assistant professor of epidemiology at the UIC School of Public Health and principal investigator of the project.

The findings should lead to new approaches to preventing prostate cancer recurrence or progression after treatment that could involve drug therapies, lifestyle changes, or both, Freeman said.

Freeman's team will enroll approximately 500 men from Chicago-area medical centers who have been diagnosed with clinically early-stage prostate cancer and who are candidates for curative therapy with surgery.

Body fat will be quantified at the time of diagnosis and one year after surgery using standard body-size measurements such as waist circumference and body mass index, and body composition measurements using X-rays to measure the relative amounts of bone, body water, and body fat.

Data will also be collected for the patient's body-weight history, diet, physical activity level, general health and socio-demographic background.

At the time of surgery, the researchers will also collect prostate tissue and fat tissue from the region of the prostate gland for a series of biochemical and molecular studies, Freeman said. They will measure fatty acids and their metabolites; the activity of a signaling pathway called the insulin-like growth factor axis; inflammatory factors that are produced by fat cells; and metabolites of male hormones. The tests "will determine whether the activity of certain metabolic pathways explains the association between body fatness and prostate cancer recurrence," Freeman said.

Patients will be followed for two years with periodic measurements of prostate-specific antigen, a protein produced by the prostate gland. Those with prostate cancer recurrence will be identified by an increasing PSA. Typically, the PSA should remain in an undetectable range following surgery for prostate cancer.


'/>"/>

Contact: Sherri McGinnis Gonzalez
smcginn@uic.edu
312-996-8277
University of Illinois at Chicago
Source:Eurekalert

Related medicine news :

1. Winner Medical Receives European Patent Office Approval for PurCotton(TM) Production Method
2. Virtua Health Receives Approval from NJHCFFA to Sell Tax-Exempt Bonds
3. Blair C. Filler, M.D. Receives 2009 Tipton Award for Outstanding Orthopaedic Leadership
4. Angiotech receives approval for Quill(TM) SRS PDO, MONODERM(TM) and Nylon product lines for sale in Canada
5. Solos Endoscopy, Inc. Receives Purchase Order from Major Connecticut Hospital for the MammoView(TM)
6. Boston University School of Medicine receives grant
7. Mylans Matrix Receives WHO Approval for First Generic, Heat-Stable Version of HIV Protease Inhibitor
8. Pharmacyclics Receives Nasdaq Notification
9. ING Run For Something Better Receives Healthy Youth for a Healthy Future Champion Award
10. International Partnership for Microbicides Receives US $130 Million from UK Government and the Gates Foundation
11. Industry Leading Data Quality and Householding Software Receives New Functionality for Enhanced Performance and Speed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out ... family verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers ... would throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. ... accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, ... and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic ...
(Date:6/24/2016)... ... ... People across the U.S. are sharpening their pencils and honing their writing ... which patients and their families pay tribute to a genetic counselor by nominating him ... Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , In April, Genome ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® & Innovative Solutions ... initiated cultivation and processing operations at its production facility, and opened its first ... is the manufacturer of a complete system of proactive air and surface purification ...
(Date:6/24/2016)... ... ... Venture Construction Group (VCG) sponsors Luke’s Wings 5th Annual ... Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. The event raised funds ... been wounded in battle and their families. Venture Construction Group is a 2016 Silver ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)...  VMS Rehab Systems, Inc. ( www.vmsrehabsystemsinc.com ) reported ... required to build a strong and stable market for ... on the OTC Markets-pink current trading platform. ... are seeing an anomaly in market trading activities that ... the Company, but shareholders and market players as well. ...
(Date:6/24/2016)... SAN FRANCISCO, Calif. , June 24, 2016 ... GBT ), a biopharmaceutical company developing novel therapeutics ... significant unmet needs, today announced the closing of ... shares of common stock, at the public offering ... shares in the offering were offered by GBT. ...
(Date:6/24/2016)... ALEXANDRIA, Va. , June 24, 2016 ... a set of recommendations that would allow ... information (HCEI) with entities that make formulary and coverage ... determine the "value" of new medicines. The ... that does not appear on the drug label, a ...
Breaking Medicine Technology: