Navigation Links
UIC receives $3 million to study prostate cancer risk factors
Date:2/27/2009

Researchers at the University of Illinois at Chicago's Institute for Health Research and Policy have been awarded a five-year, $3 million grant from the National Cancer Institute to study the link between body fat and prostate cancer progression.

Recent studies have found that obese men with prostate cancer have a higher likelihood of developing progressive or fatal disease regardless of their tumor grade and stage at diagnosis.

The UIC researchers plan to identify the biological factors responsible for poorer outcomes among obese patients, says Dr. Vincent Freeman, assistant professor of epidemiology at the UIC School of Public Health and principal investigator of the project.

The findings should lead to new approaches to preventing prostate cancer recurrence or progression after treatment that could involve drug therapies, lifestyle changes, or both, Freeman said.

Freeman's team will enroll approximately 500 men from Chicago-area medical centers who have been diagnosed with clinically early-stage prostate cancer and who are candidates for curative therapy with surgery.

Body fat will be quantified at the time of diagnosis and one year after surgery using standard body-size measurements such as waist circumference and body mass index, and body composition measurements using X-rays to measure the relative amounts of bone, body water, and body fat.

Data will also be collected for the patient's body-weight history, diet, physical activity level, general health and socio-demographic background.

At the time of surgery, the researchers will also collect prostate tissue and fat tissue from the region of the prostate gland for a series of biochemical and molecular studies, Freeman said. They will measure fatty acids and their metabolites; the activity of a signaling pathway called the insulin-like growth factor axis; inflammatory factors that are produced by fat cells; and metabolites of male hormones. The tests "will determine whether the activity of certain metabolic pathways explains the association between body fatness and prostate cancer recurrence," Freeman said.

Patients will be followed for two years with periodic measurements of prostate-specific antigen, a protein produced by the prostate gland. Those with prostate cancer recurrence will be identified by an increasing PSA. Typically, the PSA should remain in an undetectable range following surgery for prostate cancer.


'/>"/>

Contact: Sherri McGinnis Gonzalez
smcginn@uic.edu
312-996-8277
University of Illinois at Chicago
Source:Eurekalert

Related medicine news :

1. Winner Medical Receives European Patent Office Approval for PurCotton(TM) Production Method
2. Virtua Health Receives Approval from NJHCFFA to Sell Tax-Exempt Bonds
3. Blair C. Filler, M.D. Receives 2009 Tipton Award for Outstanding Orthopaedic Leadership
4. Angiotech receives approval for Quill(TM) SRS PDO, MONODERM(TM) and Nylon product lines for sale in Canada
5. Solos Endoscopy, Inc. Receives Purchase Order from Major Connecticut Hospital for the MammoView(TM)
6. Boston University School of Medicine receives grant
7. Mylans Matrix Receives WHO Approval for First Generic, Heat-Stable Version of HIV Protease Inhibitor
8. Pharmacyclics Receives Nasdaq Notification
9. ING Run For Something Better Receives Healthy Youth for a Healthy Future Champion Award
10. International Partnership for Microbicides Receives US $130 Million from UK Government and the Gates Foundation
11. Industry Leading Data Quality and Householding Software Receives New Functionality for Enhanced Performance and Speed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... ... February 05, 2016 , ... Pivot Point Consulting, a leading ... Software & Services for HIT Implementation Support & Staffing report with an outstanding ... performance by healthcare executives, managers and clinicians representing over 4,500 hospitals and 2,500 ...
(Date:2/5/2016)... ... ... Stuart Bentkover, MD, FACS is thrilled to announce the arrival of ... removal today, Dr. Bentkover is the only doctor in Central Massachusetts to offer patients ... approved by the Food and Drug Administration (FDA) as a safe and efficient method ...
(Date:2/5/2016)... ... February 05, 2016 , ... In sleep, when the ... a dream. A hallmark feature of patients with eating disorders is significant self-criticism, and ... disorder behaviors and obsessions are regarded as maladaptive means for coping with this unease, ...
(Date:2/5/2016)... ... February 05, 2016 , ... On June ... Diseases, a continuing medical education (CME) event presented by the Association for Comprehensive ... a first for ACCORD, whose mission is to provide education, tools, and resources ...
(Date:2/5/2016)... ... February 05, 2016 , ... –This week, Atascadero water heater ... having a tankless water heater. To view the report, click here or ... tankless. While each has their pros and cons, the type chosen is almost entirely ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... Feb. 4, 2016 For hospitals considering enrollment ... already participating in the program, the Health Resources and ... as the , Mega-Guidance , could have significant impact ... published in September 2016. Essential Insights , ... Marketing , summarizes the Mega-Guidance,s key proposed changes, including ...
(Date:2/4/2016)... LONDON , Feb. 4, 2016 ... to achieve significant growth as next generation systems ... and use radiology for cancer surgery. New systems ... radiological overdosing that has been such a problem ... be delivered. Radiosurgery robots take cancer surgery far ...
(Date:2/4/2016)... Wegener Polyangiitis - Pipeline Review, H2 ... Polyangiitis - Pipeline Review, H2 2015, provides an ... This report provides comprehensive information on the therapeutic ... at various stages, therapeutics assessment by drug target, ... and molecule type, along with latest updates, and ...
Breaking Medicine Technology: