Navigation Links
UIC leads multi-center study to evaluate blood flow and stroke risk
Date:9/9/2008

The University of Illinois at Chicago has been awarded a five-year, $2.1 million grant from the National Institute of Neurological Disorders and Stroke to lead a multi-center study to assess blood flow and stroke risk.

Ischemic strokes -- the type caused by clots rather than bleeds in the brain -- account for 80 percent of all strokes and represent a major source of death and disability. They are often caused by atherosclerosis, a build-up of plaque inside the walls of blood vessels.

Advances in endovascular techniques, such as threading a catheter to open up a blockage, or placing a stent in a vessel, provide new treatment options for patients with stroke. But these interventions carry risks, and physicians don't always know which patients are appropriate candidates for these procedures.

"There's been a lot of emphasis in prior medical research on the type of stroke that affects the anterior circulation, or blood supply to the major lobes in the front of the brain," says Dr. Sepideh Amin-Hanjani, UIC assistant professor of neurological surgery and principal investigator of the study.

"But there's another set of arteries that supply the back part of the brain, including the brainstem, which is a smaller, but in some ways, a much more functionally important part of the brain with a lot of important real estate," she said.

Even a very small stroke in this area of the brain can have very devastating consequences, Amin-Hanjani said.

Until recently, it has been difficult for researchers to measure blood flow in the vertebral arteries to the back of the brain. But they hypothesize that patients with vascular disease in these arteries have low blood flow and are at higher risk of stroke.

The study will enroll 80 patients at five sites who have first-time stroke symptoms caused by 50 percent or greater blockage of the arteries leading to the back of the brain.

Patients will receive standard brain imaging with MRI or CT, imaging of the blood vessels, and possible medication therapy, which might include aspirin, anti-cholesterol medication, or blood pressure lowering medication.

As part of the study, patients will additionally undergo magnetic resonance (MR) perfusion and quantitative magnetic resonance angiography (QMRA) that measures blood flow using "NOVA" technology developed by UIC neurosurgeon Dr. Fady Charbel. The Noninvasive Optimal Vessel Analysis measures the volume of blood flow, direction, and provides a four-dimensional view of the shape and form of blood flow.

Patients will be imaged when they are first enrolled in the study and six and 12 months later. They will be monitored monthly for any recurrent symptoms that would suggest a stroke.

After following the participants for a minimum of one year, researchers will compare the blood flow of patients who had a stroke since their initial symptoms with those patients who did not have stroke.

"We hypothesize that patients who have better blood flow to their brains are going to be the ones that don't have new strokes, and those that have low blood flow on their brain scans will be at higher risk of having strokes," said Amin-Hanjani.

If this is demonstrated, then patients with low blood flow to their brain -- even when they first have stroke symptoms -- may be candidates for intervention such as stenting or angioplasty to increase blood flow, said Amin-Hanjani. At the same time, people who have stroke symptoms but normal blood flow could be reassured that their risk of stroke on medication therapy is low, and there may be no need for further intervention exposing them to unnecessary risk.

"If we know who is at highest risk, we may be able to figure out who is going to benefit the most from interventional treatment," said Amin-Hanjani. "Given that treatment such as stenting is not entirely risk free, it would be important to know that you're treating the highest risk population and offering them a benefit, rather than treating patients who may not need it."


'/>"/>

Contact: Sherri McGinnis Gonzalez
smcginn@uic.edu
312-996-8277
University of Illinois at Chicago
Source:Eurekalert

Related medicine news :

1. Association for the Advancement of Wound Care Leads World Health Organization Initiative to Establish Guidelines for Wound and Lymphedema Care
2. Rise of Global Deaths and Chronic Diseases Leads to Summit on Protecting Global Employee Health
3. Telemedicine leads to better stroke treatment decisions
4. Age-old money matters: Positivity in older adults leads to balanced investments
5. Greenway Medical Technologies Leads Ambulatory Interoperability Exchange
6. Beauty Counter Direct Leads Customers Through the Maze of Self Tanning Products
7. Tufts researcher leads revision of osteoporosis guidelines
8. International Research Organization Responds to Recent Studies Purporting to Show That Transfusion of Older Red Blood Cells Leads to Greater Risk
9. The Quantum Group Completes Corporate Expansion Plan; Employee and Corporate Office Growth Leads the Way for Enhanced Innovation and Growth Through 2009
10. Spectranetics Introduces New Device for Removal of Non-Functional and Infected Cardiac Leads
11. AUA 2008: Low cholesterol leads to lower PSA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... ... ... Alert Sentry Group LLC., a leader in the Personal Emergency Response System industry, introduced ... Plus. These iSAFE products are the most affordable and most advanced medical alert systems ... direct GPS Location and two-way calling with the push of a button on a ...
(Date:3/28/2017)... ... 28, 2017 , ... The Radiology Business Management Association (RBMA) is ... its new executive director. Mr. Still was selected through a careful months-long search by ... he is known to our members, has been a part of building the RBMA ...
(Date:3/28/2017)... ... March 28, 2017 , ... Neurotechnology , a provider ... and attendance tracking products: the new NCheck Cloud Bio Attendance cloud-based service and ... biometric face recognition to enable users to check in and out from anywhere ...
(Date:3/28/2017)... ... 2017 , ... The Executives, Staff & Clients of MGE: Management Experts joined ... Tots Literacy Campaign at their Semi-Annual Graduation and Fundraiser Event at MGE’s St. Petersburg ... at number 14 internationally in literacy. Statistically, a direct relation can be a found ...
(Date:3/28/2017)... ... March 28, 2017 , ... Prominant bariatric ... Inc. is thrilled to offer the recently FDA-approved Obalon Balloon System to his ... to SkyLex Advanced Surgical’s already comprehensive list of weight-loss services. Dr. Liu ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... March 27, 2017 Summary ... understand Bayer and its partnering interests and activities since 2010. ... provides an in-depth insight into the partnering activity of one ... demand company reports are prepared upon purchase to ensure inclusion ... The report will be delivered in PDF format ...
(Date:3/27/2017)... , March 27, 2017  A recent study ... only four freestanding hospitals in the country dedicated to ... and reconstructive surgery, concluded that the Surfacide Helios ® ... integral component in reducing bacterial pathogens not killed by ... were published at the American Burn Association,s 49th Annual ...
(Date:3/27/2017)... March 27, 2017 LightIntegra Technology Inc. today ... "Bill" Dubiel as President and Chief Executive Officer effective ... the Board of Directors of LightIntegra. Paul Geyer ... of LightIntegra. "This is the perfect ... Chief Executive Officer. We,ve selected a very strong leader ...
Breaking Medicine Technology: