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UI researchers find early predictor for preeclampsia
Date:7/8/2014

o reliable way to predict and prevent preeclampsia. The only thing you can do to protect a baby and a mother from some of the negative effects of preeclampsia is to deliver the baby, and most of the time that results in a preterm birth."

The researchers believe this discovery will majorly impact obstetric care in rural and underserved communities. Determining very early that a pregnancy is going to be preeclamptic is significant, the researchers say, so doctors can help expecting mothers by heightening their awareness of significant symptoms of preeclampsia or if need be, transfer them to hospitals able to provide the appropriate, higher level of medical care.

"Sometimes symptoms of normal pregnancy such as headaches, occasional blurry vision, abdominal pain, and swelling are really symptoms of preeclampsia and not something that should just be dismissed without testing by healthcare providers." Donna Santillan says. "Being able to determine that a pregnancy is affected by preeclampsia early will help women pay careful attention to their symptoms and to get medical care before the effects of preeclampsia becoming severe for both the mother and baby. The women who have participated in this study by donating their blood samples have made a great contribution to advancing the health of women."

What the researchers found was that maternal plasma copeptin an inert, stable biomarker of vasopressin secretion with a substantially longer half-life in the blood than vasopressin is a clinically useful biomarker that predicts preeclampsia. Using samples from the Maternal Fetal Tissue bank, a major part of the University of Iowa Women's Health Tissue Repository, copeptin levels were measured throughout pregnancy in maternal plasma from preeclamptic and control women. Copeptin levels were significantly higher throughout the preeclamptic pregnancies than in the control pregnancies.

The group is currently working to determine if the copep
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Contact: Molly Rossiter
molly-rossiter@uiowa.edu
319-356-7127
University of Iowa Health Care
Source:Eurekalert

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