Navigation Links
UH researchers explain hormonal role in glucose and fat metabolism
Date:9/29/2011

HOUSTON, Sept. 29, 2011 Hormone researchers at the University of Houston (UH) have their sights set on providing long-term treatment options for diabetes, obesity and cardiovascular diseases by better understanding estradiol, the most potent naturally occurring estrogen.

They now believe that this estrogen hormone is a prominent regulator of several body functions in both females and males. While estradiol is more commonly associated with processes and diseases specific to women, the team determined that the hormone actually functions as a unisex hormone with multiple actions. Research has indicated that when there is an excessive or insufficient amount of estradiol present, the metabolic network becomes imbalanced, which can result in metabolic diseases.

"Female hormones have always been associated with the menstrual cycle, pregnancy, breast-feeding and some diseases, such as osteoporosis and breast cancer, typically associated with women," said Dr. Rodrigo Barros, a research assistant professor with the UH Center for Nuclear Receptors and Cell Signaling (CNRCS). "Our group, however, has discovered that one of these hormones, estradiol, has much wider actions than previously thought. It is no longer considered exclusively a 'female sex hormone,' but a 'unisex hormone' with multiple actions across several organ systems."

Working with CNRCS director and professor Dr. Jan-ke Gustafsson, Barros says that part of their research is dedicated to understanding how estradiol regulates feeding and food metabolism, explaining that this hormone is involved with several metabolic diseases, including eating disorders, obesity and diabetes.

"We believe that all the systems in the body involved with food consumption and metabolism, which include the brain, liver, pancreas, heart, muscles and fat, are connected by estradiol, resulting in a 'metabolic network' regulated by the hormone," Barros said. "Our evidence shows that when too much or too little estradiol is available, this delicate network loses its balance and metabolic diseases set in."

This research has important implications for the average consumer, as well as for physicians. While hormones like estradiol are important for the adequate maintenance of body functioning, they may pose serious risks to a person's health if misused as supplements. This comes into play when people use alternative forms of hormones, such as natural plant derivatives, that may be harmful if used inappropriately.

For specialists dealing with hormonal treatments, this research underscores that they should be aware that several organs and body functions are affected when estradiol is prescribed and may cause or worsen metabolic diseases. Due to the number of organs and functions affected by fluctuating levels of estradiol, its use as a hormonal treatment for patients with delayed puberty, menopausal symptoms, osteoporosis and prostate cancer is a source of debate within the medical and research communities. Exploring the impact of such treatments as reported by Barros and Gustafsson is helpful for keeping these professionals abreast of new research and guidelines.


'/>"/>

Contact: Lisa Merkl
lkmerkl@uh.edu
713-743-8192
University of Houston
Source:Eurekalert  

Related medicine news :

1. Researchers identify enzyme that regulates degradation of damaged proteins
2. UTHealth researchers train promotoras to combine mobile technology, cancer prevention messages
3. Researchers uncover gene associated with blood cancers
4. Boston researchers share in $10 million grant to study HIV and alcohol
5. Rhode Island Hospital researchers find possible cardiovascular risk with NSAID use
6. Decoding vaccination: Mayo researchers reveal genetic underpinnings of response to measles vaccine
7. Researchers discover how promiscuous parasites hijack host immune cells
8. Buyer beware: Advertising may seduce your brain, UCLA researchers say
9. Researchers Find Link Between Epilepsy, Schizophrenia Risk
10. Researchers identify components that keep immune system in check
11. Researchers identify potential molecular target to prevent growth of cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UH researchers explain hormonal role in glucose and fat metabolism
(Date:2/19/2017)... ... February 19, 2017 , ... Braun Industries will be participating as ... the event will take place February 23-25, 2017 at the Calvin L. Rampton Salt ... #909 with three new ambulances on display. , “JEMS is a ...
(Date:2/19/2017)... (PRWEB) , ... February 19, 2017 , ... ... proven to result in better care, and MEDfx and the Delaware Health Information ... of Delaware. , As the nation’s first state-wide health information exchange, DHIN stores ...
(Date:2/18/2017)... ... February 17, 2017 , ... ... Free Webinar**, March 1, 2017 — 1:30 p.m. – 2:30 p.m. ET, ... Pay dividends in enhanced and predictable product performance? Streamline processes resulting in ...
(Date:2/18/2017)... ... February 17, 2017 , ... Butler Mobility invited Ken Matthews to visit ... Butler products. Ken was impressed with the safety and reliability of the Stannah ... on his show. This endorsement by Ken Matthews can be heard on News ...
(Date:2/18/2017)... ... February 17, 2017 , ... Park Cities Pet Sitter President, Joette White, has ... Life Radio network. The episode, which was posted this week, features a 30-minute ... led to Park Cities Pet Sitter’s being awarded the 2017 National Association of Professional ...
Breaking Medicine News(10 mins):
(Date:2/20/2017)... 2017 Systems Magnetic resonance imaging ... of the organs and tissues in the body with ... The technique does not use ionizing radiation either for ... growth of cancer. MRI is used for a variety ... and orthopedics. Hence, MRI helps in the diagnosis and ...
(Date:2/20/2017)... Feb. 20, 2017  Henry Schein, Inc. (Nasdaq: HSIC), ... products and services to office-based dental, animal ... it has entered into an agreement to ... leading U.S. distributor of anesthesia and surgical ... periodontists. SAS offers controlled and non-controlled pharmaceuticals, ...
(Date:2/20/2017)...  National Decision Support Company (NDSC) announces its ... Imaging platform within the full range of MEDITECH ... foundation for MEDITECH sites, through a directly supported ... Support Mechanism through the MEDITECH EHR. ... the integration of NDSC,s mechanism, which enables provider ...
Breaking Medicine Technology: