Navigation Links
UH biochemist works to revolutionize ovarian cancer treatment
Date:12/21/2010

ientists discovered that microRNAs might actually be the hidden regulators that control the 30,000 genes in the human body by silencing gene expression. Gunaratne has been at the vanguard of this development. With its 2008 acquisition of a $1 million genome sequencer device the Illumina Genome Analyzer UH instantly became a major player in this cutting-edge research. This state-of-the-art machine can rapidly deconstruct and analyze millions of pages worth of genetic data and allowed Gunaratne's lab to sequence hundreds of normal and diseased tissue samples.

Gunaratne set her sights on a variety of cancers, including ovarian tumors, pediatric neuroblastoma and multiple myeloma. Using the sequencer in collaboration with Baylor, Texas Children's Cancer Center and the Lurie Cancer Center at Northwestern University, her team created a unique database documenting genome-wide patters of microRNA and gene expression across an array of human tissues and cancers. The ultimate goal is to connect specific microRNAs with the genes they regulate, individualized to attack specific genomes.

From this database, Gunaratne's team was able to pinpoint a handful of microRNAs in the human body that can significantly or completely suppress the growth of cancer cells. One in particular, miR-31, discovered by Baylor collaborators and Gunaratne, shows promise as a potent tumor suppressor in ovarian cancer, glioblastoma, osteosarcoma and prostate cancer.

They discovered that miR-31 can specifically target and kill cancer cells that are deficient in p53, a crucial gene that guards the integrity of the genome and prevents cancer. More than half of all cancers and 90 percent of papillary serous tumors the most common type of malignant ovarian cancer are p53-deficient.

In cell cultures miR-31 suppressed and killed tumor cells deficient in p53, while sparing cells with a normal p53 gene. Since all non-cancerous cells in the body would be resistant to miR
'/>"/>

Contact: Lisa Merkl
lkmerkl@uh.edu
713-743-8192
University of Houston
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. Biochemist studies DNA repair with $787,000 in grants
2. Mapping faculty social networks helps female faculty move ahead at NJIT
3. Smoke from fireworks is harmful to health
4. More Evidence That Compression-Only CPR Works Best
5. For Common Warts, Freezing Therapy Works Best: Study
6. Treatment for S. aureus skin infection works in mouse model
7. SUMO works with replication protein A complex to repair DNA
8. U of A works with Health Canada to test residential indoor air quality
9. Dose optimization workshop helps reduce radiation dose associated with MDCT scans
10. Researchers uncover biological rationale for why intensive lupus treatment works
11. Technology for locating first responders in buildings to be showcased at national workshop
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UH biochemist works to revolutionize ovarian cancer treatment
(Date:8/21/2014)... 21, 2014 The costs paid by consumers ... rise, according to insurer data. The Quotes Pros company is ... time using its tools at http://quotespros.com . , ... homepage connects with providers offering multiple coverage packages for dental ... to the public are now easier to compare using the ...
(Date:8/21/2014)... Today, Zane Benefits, the #1 Online Health ... credits in 2015. , According to Zane Benefits, premium ... Affordable Care Act (ACA), premium tax credits are available ... through the Health Insurance Marketplaces. , The new article ... of the tax credits, updated for 2015. , ...
(Date:8/21/2014)... Calcium buildup in the coronary arteries of chronic kidney ... disease risk, according to a new study in the ... ( JASN ). Researchers at the Johns Hopkins Bloomberg ... two other commonly used measures of subclinical atherosclerosis in ... kidney disease. , Approximately 50 percent of all patients ...
(Date:8/21/2014)... University of Texas MD Anderson Cancer Center today announced ... specialized breast screening at a network of community breast ... in late November, MD Anderson will become the exclusive ... Memorial Hermann,s 10 breast care centers, located in Memorial ... Over time, the network will expand to Memorial Hermann,s ...
(Date:8/21/2014)... Aug. 21, 2014 (HealthDay News) -- Not only is eating ... save them hundreds of health-care dollars a year, a new ... professor of public health sciences at Wake Forest Baptist Medical ... and obese type 2 diabetes patients. Participants ... assigned to either an intensive "lifestyle change program" focused on ...
Breaking Medicine News(10 mins):Health News:Dental Insurance Now Quoted for Families Online at Insurer Portal 2Health News:Measuring calcium buildup to predict heart disease in those with chronic kidney disease 2Health News:MD Anderson and Memorial Hermann to operate breast screening network across Houston area 2Health News:Getting Healthier a Big Money-Saver for People With Diabetes 2
... Sciton introduces ProLipo,PLUS(TM), an FDA-cleared, minimally invasive, ... fat, resulting in collagen remodeling and,tissue tightening. ... wavelengths in,one laser for optimal body sculpting results. ... it can also be utilized as a standalone ...
... FOR CAREER OF SCIENTIFIC DISCOVERY IN MOLECULAR IMAGING , ... The Radiologic Society of North America (RSNA) honored Ralph Weissleder, ... recognition afforded annually to one scientist who has made original ... of research. Dr. Weissleder is Professor at Harvard Medical ...
... to qualified recipients , , ... honor 31 recipients of the 2008 UCB Family Epilepsy Scholarship(TM) at ... American Epilepsy Society Annual Meeting. The scholarship is awarded to ... seek personal growth through higher learning. , , ...
... Transcept Pharmaceuticals,Inc., a privately-held specialty pharmaceutical company, announced ... is scheduled to,participate at the RBC Capital Markets 2008 ... "Delivering Novel Drug Solutions: The Future of Drug,Delivery." ... December,11, 2008 at 1:30 PM Eastern Time. , ...
... Americans cut prescription costs without compromising drug safety , ... A collection of online educational materials are now ... the dangers of contaminated or counterfeit drugs. Unveiled ... is designed to help consumers ensure the safety of ...
... and Alternative Risk Transfer Capabilities Further Expand Company,s Specialty Offerings- , ... Partner Agents- , , WORCESTER, Mass., ... THG ), a leading super regional property and casualty company, announced ... Holdings, Inc. , , (Logo: ...
Cached Medicine News:Health News:Sciton Introduces ProLipo PLUS(TM), the Most Robust Laser-Assisted Lipolysis System Available 2Health News:VisEn Co-Founder Named Radiologic Society's 'Outstanding Researcher of the Year' 2Health News:VisEn Co-Founder Named Radiologic Society's 'Outstanding Researcher of the Year' 3Health News:Unique Scholarship Helps People Affected by Epilepsy Fulfill Life Ambitions 2Health News:Unique Scholarship Helps People Affected by Epilepsy Fulfill Life Ambitions 3Health News:Unique Scholarship Helps People Affected by Epilepsy Fulfill Life Ambitions 4Health News:Transcept Pharmaceuticals to Participate on Drug Delivery Investor Panel 2Health News:Partnership for Safe Medicines Arms Public Against Counterfeit Drugs 2Health News:Partnership for Safe Medicines Arms Public Against Counterfeit Drugs 3Health News:Partnership for Safe Medicines Arms Public Against Counterfeit Drugs 4Health News:The Hanover Insurance Group Completes Acquisition of AIX Holdings, Inc. 2Health News:The Hanover Insurance Group Completes Acquisition of AIX Holdings, Inc. 3
(Date:8/21/2014)... 2014  The board of directors of VirtualScopics, Inc. ... clinical trial imaging solutions, today announced that James ... effective immediately.  Mr. Groff has held the role of ... VirtualScopics in January 2006 as an accounting manager and ... "When the board of VirtualScopics asked Jim to assume ...
(Date:8/21/2014)... 21, 2014 /CNW/ - Bedrocan Cannabis Corp., previously Bedrocan ... to its Board of Directors, enhancing executive oversight ... company, a leading licensed producer of medicinal cannabis ... has 13 years, experience in producing and supplying ... including Canada. As previously announced ...
(Date:8/21/2014)... 2014  Cyberonics, Inc. (NASDAQ: CYBX ) today ... Quarterly highlights 1   Operating results ... first quarter of fiscal 2014, and other achievements, include: ... of 6.8%; , Strong international net sales of $13.2 ... , U.S. net product sales reached a new high ...
Breaking Medicine Technology:VirtualScopics, Inc. Names James Groff Chief Financial Officer 2VirtualScopics, Inc. Names James Groff Chief Financial Officer 3VirtualScopics, Inc. Names James Groff Chief Financial Officer 4Senior Life Sciences Executives Join Bedrocan as Independent Directors 2Senior Life Sciences Executives Join Bedrocan as Independent Directors 3Cyberonics Reports Fiscal 2015 First Quarter Results 2Cyberonics Reports Fiscal 2015 First Quarter Results 3Cyberonics Reports Fiscal 2015 First Quarter Results 4Cyberonics Reports Fiscal 2015 First Quarter Results 5Cyberonics Reports Fiscal 2015 First Quarter Results 6Cyberonics Reports Fiscal 2015 First Quarter Results 7Cyberonics Reports Fiscal 2015 First Quarter Results 8Cyberonics Reports Fiscal 2015 First Quarter Results 9Cyberonics Reports Fiscal 2015 First Quarter Results 10Cyberonics Reports Fiscal 2015 First Quarter Results 11Cyberonics Reports Fiscal 2015 First Quarter Results 12Cyberonics Reports Fiscal 2015 First Quarter Results 13Cyberonics Reports Fiscal 2015 First Quarter Results 14Cyberonics Reports Fiscal 2015 First Quarter Results 15Cyberonics Reports Fiscal 2015 First Quarter Results 16
... 20, 2010 ... ... --> ... // Results are keyed by longUrl, so we need to grab the first one. for (var r in data.results) ...
... Beaumont Hospitals, world renowned heart center has expanded and ... the new Ernst Cardiovascular Center at Beaumont Hospital, Royal ... Cardiovascular Center offer breakthrough surgeries and treatments for people ... also the new home for Beaumont,s innovative "7 tests ...
Cached Medicine Technology:Cipla Launches the World's First Generic Pirfenidone in India, Giving Hope to Sufferers of IPF (Idiopathic Pulmonary Fibrosis) 2Cipla Launches the World's First Generic Pirfenidone in India, Giving Hope to Sufferers of IPF (Idiopathic Pulmonary Fibrosis) 3Cipla Launches the World's First Generic Pirfenidone in India, Giving Hope to Sufferers of IPF (Idiopathic Pulmonary Fibrosis) 4Cipla Launches the World's First Generic Pirfenidone in India, Giving Hope to Sufferers of IPF (Idiopathic Pulmonary Fibrosis) 5Cipla Launches the World's First Generic Pirfenidone in India, Giving Hope to Sufferers of IPF (Idiopathic Pulmonary Fibrosis) 6Cipla Launches the World's First Generic Pirfenidone in India, Giving Hope to Sufferers of IPF (Idiopathic Pulmonary Fibrosis) 7Cipla Launches the World's First Generic Pirfenidone in India, Giving Hope to Sufferers of IPF (Idiopathic Pulmonary Fibrosis) 8Beaumont Hospital Opens New Ernst Cardiovascular Center 2
Its MicroPoint design and reference marks at 10, 50 and 100 L ensure accurate performance with a variety of multi-channel and single-channel pipettors....
... its wide orifice tip, the Finntip Wide ... suspensions and macromolecules like genomic DNA. This ... cell fragmentation. It is excellent for use ... model, the inside diameter of the orifice ...
For plaque coring...
Capillary section fits into a 0.3-mm well for accurate loading of sequencing gels...
Medicine Products: