Navigation Links
UH Rainbow Babies & Children's Hospital begins studies on vitamin D to prevent heart disease
Date:11/8/2011

CLEVELAND -- While Vitamin D is essential for proper bone health, a number of research studies have linked it to guarding against cardiovascular disease and certain cancers. It is unique among vitamins in that it is made by the body in response to sunlight but is naturally present in very few foods. Recent studies have confirmed that vitamin D deficiency is common, even in sunny states such as Florida.

People who are HIV-positive, of all ages and all races, may be at particularly high risk of having vitamin D deficiency, in part, because certain HIV medications appear to lower vitamin D levels.

University Hospitals (UH) Rainbow Babies & Children's Hospital will be looking at the role of Vitamin D in preventing heart disease in children and young adults who are both HIV-positive and HIV-negative. The studies are being led by Grace McComsey, M.D., Division Chief, Pediatric Infectious Diseases, Rheumatology & Global Child Health at UH Rainbow Babies & Children's Hospital and a Professor of Pediatrics at Case Western Reserve University School of Medicine.

"In HIV-positive populations now, we have made great strides in helping patients live productive lives with the help of medications," said Dr. McComsey. "However, we are finding that patients are experiencing higher rates of heart disease and cancer."

While children and young adults with HIV may not yet experience outward symptoms of heart disease at their age, ultrasounds are already revealing abnormal vessel thickness or plaques compared to healthy youth. These kids are at a significantly higher risk than the general population for heart disease. In adults with HIV, research has shown that the risk of heart disease rises by 26 percent for every year of treatment. For these kids who will likely be on HIV medications for decades, heart disease is an important risk.

"The large success we have had in helping them live longer through HIV medications is now threatened by an increase risk of heart disease," said Dr. McComsey.

Dr. McComsey said the increased risk is due at least in part, to heightened inflammation in these patients and that several studies had indicated that deficiency in Vitamin D may increase inflammation and heart disease risk.

In two new UH Rainbow Babies & Children's Hospital studies, a total of 240 HIV-positive and 240 HIV-negative patients will be studied to understand how Vitamin D deficiency affects inflammation, immune system and risk of heart disease. Also, participants with low vitamin D levels will be randomly assigned to one of three oral dose levels of monthly vitamin D to determine which dose may be the best for reducing heart disease, inflammation as well as boosting the immune system and bone density.

Heart and bone disease, inflammation and immune system function will be measured through biomarkers found in blood and urine samples, and through ultrasound tests that can reveal blockage in arteries and measure thickness of bone. The researchers will also look at the effect of HIV medications on accelerating vitamin D deficiency.

"Vitamin D may present a safe opportunity to reverse the increased cardiovascular disease risk and immune co-morbidities in the HIV population," said Dr. McComsey. "Optimizing Vitamin D concentrations early in the course of HIV infection could offer a simple and cost-effective approach to minimize the risk of HIV-related heart disease and preserve immune function."

In the non-HIV study, researchers are hoping to also find an optimal level of Vitamin D that will help decrease heart risk and inflammation. That is because, similar to the case in HIV, data is also surfacing in the general population linking low vitamin D in the blood to higher risk of heart disease and cancer, both thought to be possibly the result of high inflammation and/or altered immune status.


'/>"/>
Contact: George Stamatis
george.stamatis@uhhospitals.org
216-844-3667
University Hospitals Case Medical Center
Source:Eurekalert

Related medicine news :

1. HealthCare Partners of Nevada and Rainbow Medical Center Join Forces
2. Babies and toddlers should learn from play, not screens
3. Low-Birthweight Babies at Much Higher Autism Risk
4. Boys With Autism May Grow Faster as Babies
5. Lung function of moderately premature babies is reduced at 8-9 years but may improve with age
6. Bilingual Homes Help Babies Exercise Their Brain: Study
7. Toothless Grins Are Only Cute on Babies
8. Babies Born With Heart Disease Often Harmed by Gut Bacteria
9. Mothers Love Can Help Babies With Difficult Temperaments
10. Can oral care for babies prevent future cavities?
11. Prenatal Omega-3 Fatty Acid Supplements May Cut Babies Colds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2016)... Aliso Viejo, California (PRWEB) , ... December 10, 2016 , ... ... editors to create dozens of unique animations," said Christina Austin - CEO of Pixel ... created exclusively for use within FCPX . This set of versatile transitions ...
(Date:12/10/2016)... ... December 10, 2016 , ... When faced with having ... germs spreading from the seat to her body, and contamination of children when they ... way to solve this problem that many people face. , The patent-pending SANI-POCKET enables ...
(Date:12/9/2016)... ... December 09, 2016 , ... Cellairis is a worldwide mobile device and ... iPhone , iPad and Samsung Galaxy devices with premium parts and accessories. ... to maximize convenience and accessibility for customers. While customers do their shopping, Cellairis can ...
(Date:12/9/2016)... ... December 09, 2016 , ... The Justin Veatch Fund ... (NCADD) is recommending the film Whispering Spirits and its discussion guide ... Columbia as an education tool in the war against teen drug abuse. NCADD ...
(Date:12/9/2016)... NY (PRWEB) , ... December 09, 2016 , ... Mediaplanet ... awareness for organ transplantation while encouraging readers to sign up as an organ donor ... lifesaving organ transplant. , An organ donor can save up to 8 saves ...
Breaking Medicine News(10 mins):
(Date:12/9/2016)... Dec. 9, 2016   Hudes Laser Aesthetica ... featuring the multi-wavelength Astanza Trinity laser and Astanza ... in laser tattoo removal, IPL hair removal, pigmented ... therapy. Hudes Laser Aesthetica is setting high standards ... and promises to deliver effective, long-lasting results. ...
(Date:12/9/2016)... , Dec 9, 2016 Research ... Transceiver Market 2016-2020" report to their offering. ... The report forecasts the global ... the period 2016-2020. The report covers the present ... for 2016-2020. To calculate the market size, the report considers the ...
(Date:12/9/2016)... 2016  Harmar Mobility, LLC announced today that Steven E. Dawson has ... Board of Directors. Photo - http://photos.prnewswire.com/prnh/20161209/447552 ... Harmar ... Mr. Dawson,s executive career includes leadership roles ... variety of industries. He brings to the company deep operational and leadership ...
Breaking Medicine Technology: