Navigation Links
UGR and Michael J. Fox Foundation take a step forward in the study of Parkinson's disease
Date:11/9/2012

This press release is available in Spanish.

During the past year, the research group TIC 218 at the Department of Signal Theory, Telematics and Communications attached to the University of Granada and the Andalusian Information Technology and Communications Center (CITIC) has implemented the methods for the detection and diagnosis of Alzheimer's disease, within the PPMI initiative of the Michael J. Fox foundation for the study of Parkinson's disease. In addition, other databases were used such as that of the Virgen de la Victoria Hospital, Mlaga, Spain, and Virgen de las Nieves Hospital, Granada, Spain.

The research studies were financed by the Andalusian Regional Government through its excellence research program calls TIC-4530, TIC-2566 and TIC-7103. Additional funds were granted by the Spanish National R&D Plan call TEC2008-02113 and "DiagnoSIS" TEC2012-34306. The research group has been awarded several prizes as the University of Granada Premio del Consejo Social and the Andalusian Regional Government's Premio Andaluca Sociedad de la Informacin.

This research group has published more than 40 papers indexed in the ISI-JCR in the field of diagnosis and scan imaging analysis. The last three papers devoted to the study of Parkinson's disease- have been published in the most prestigious journals in the field of neuroscience such as Medical Physics (impact index 3.075) and NeuroImage (impact index 5.985, N1 journal in its category).

Undestanding the behavior of brain functions in patients with Parkinson's disease

The introduction of SPECT imaging worldwide for the diagnosis of Parkinson's disease (PD) based on the innovative DaTSCAN agent has allowed experts to better understand the behavior of behavior of brain functions in patients diagnosed with Parkinson's disease. The data provided by SPECT images can be processed by pattern-recognition machine, which allow an objective analysis of data.

A collaborative work with Virgen de la Victoria Hospital

The latest study conducted by this research group (Automatic assistance to Parkinson's disease diagnosis in DaTSCAN SPECT imaging. I. A. Illn, J. M. Grriz, J. Ramrez, F. Segovia, J. M. Jimnez-Hoyuela, and S. J. Ortega Lozano Med. Phys. 39, 5971 (2012)) presents a computer procedure that does not need the intervention of an expert (normalization, location of relevant regions, "clinical eye"...). In addition, this new technique systematically analyzes the effect of the different elements involved in the building process of the computer-assisted diagnosis technique on the accuracy of the final diagnosis. As a result, the technique proposed may exceed 90% of accuracy in the diagnosis of PD with the right selection of elements, and with the additional advantage of being a robust and simple computer software.

Similarly, the researchers at the research group SiPBA TIC 218 recently published the paper Improved Parkinsonism diagnosis using a partial least squares based approach. (F. Segovia, J. M. Grriz, J. Ramrez, I. lvarez, J. M. Jimnez-Hoyuela, and S. J. Ortega, Med. Phys. 39, 4395. 2012), an enhanced versin of the former paper with the same title. In this paper, researchers propose a method consisting on separating brain hemispheres to fulfill two goals: firstly to correctly diagnose AD when it only affects one hemisphere (in many patients, PD evolves asymmetrically during the first stages)

A Paper Accepted for the Prestigious Journal Neuroimage

The group SiPBA has also developed a method for the linear normalization of intensity of FP-CIT SPECT-type brain images, which are generally used in the diagnosis of PD. The method proposed is based on experimental evidence that the histogram of image intensity values can be accurately adjusted using only four parameters through asymmetric Levy-stable distributions.

In this study, stable-distribution parameters, concretely those of scale and position, are used to linearly convert the intensity values for each voxel. This conversion is performed in such a way that the new intensitivy histograms for each brain image have the same values for the parameters position and dispersion. The proposed method has a better performance that the traditional intensity normalization method, which is based on the ration between the intensity values of specific and non-specific brain regions.

This paper, titled Linear intensity normalization of FP-CIT SPECT brain images using the alpha-stable distribution, D. Salas-Gonzalez, J. M. Grriz, J. Ramrez, I. A. Illn, E.W. Lang, and the Parkinson's Progression Markers Initiative (PPMI), has been recently accepted for publication in the journal Neuroscience, which is the top journal in the Thomson/ISI ranking, with 5,898 impact points.


'/>"/>

Contact: Juan Manuel Grriz Sez
gorriz@ugr.es
34-958-243-271
University of Granada
Source:Eurekalert

Related medicine news :

1. The Tennessee Car Accident Lawyers at Michael D. Ponce & Associates Alert Public of CDC Survey Revealing Majority of High School Seniors Admitting to Texting Behind Wheel
2. Dr. Arthur Slutsky, vice-president of research at St. Michaels, receives lifetime award
3. Dr. Taub to give Estabrook Research Lecture at Kessler Foundation on Nov. 28
4. Edith Sanford Breast Cancer Foundation and TSRI partner in genomic breast cancer research
5. Kessler Foundation scientists awarded New Jersey grants for brain injury research
6. Research prizes from the Carlsberg Foundation to researchers from University of Copenhagen
7. Kessler Foundation scientist garners best poster award for MS research
8. Dr. Chiaravalloti of Kessler Foundation comments on trends in rehabilitation research in MS
9. Kessler Foundation presents Brain Injury: From Research to Rebuilding Lives on Sept. 27-28
10. CU study awarded grant from Moore Foundation
11. Society of Interventional Radiology Foundation: Medical students will make a difference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out ... free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting ... children of all ages; it is a non-competitive, non-timed event, which is all about ...
(Date:10/13/2017)... ... 13, 2017 , ... “The Journey: From the Mountains to the Mission Field”: ... souls in the Philippines. “The Journey: From the Mountains to the Mission Field” is ... Bible. She has taught all ages and currently teaches a class of ladies at ...
(Date:10/12/2017)... ... 12, 2017 , ... Planet Fitness, one of the largest and fastest growing ... open a flagship location in Covington, LA at 401 N. U.S. Highway 190, in ... to Office Depot in the Holiday Square shopping center. Its location allows it to ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a nationally ... care, have expanded their existing home health joint venture through an agreement, effective ... operating a joint venture home health company with Asante, delivering clinically integrated care, ...
(Date:10/12/2017)... Washington, D.C. (PRWEB) , ... October 12, 2017 , ... ... of their peers in Washington, D.C., for the 49th Congress of the International ... Ph.D ., Vice President of the Center for Cancer and Blood Disorders ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... Mass. , Oct. 4, 2017 ... of single-use, self-contained, illuminating medical devices, today announced ... National Health Surveillance Agency (or Agência Nacional de ... The first single-use, cordless surgical retractor with integrated ... provides optimal access, illumination and exposure of a ...
(Date:10/2/2017)... announces the European launch of their new low volume, high throughput ... Cambridge, U.K on October 4th. The new ... unprecedented speed and sensitivity while using far less sample volume through ... ... ...
(Date:9/27/2017)... Sept. 27, 2017  Commended for their devotion to personalized ... Ranked as number one in the South Florida Business Journal,s ... Inc. 5000 yearly list, the national specialty pharmacy has found ... Bardisa will soon be honored by SFBJ as the ... Set to receive his award in October, Bardisa ...
Breaking Medicine Technology: