Navigation Links
UGR and Michael J. Fox Foundation take a step forward in the study of Parkinson's disease
Date:11/9/2012

This press release is available in Spanish.

During the past year, the research group TIC 218 at the Department of Signal Theory, Telematics and Communications attached to the University of Granada and the Andalusian Information Technology and Communications Center (CITIC) has implemented the methods for the detection and diagnosis of Alzheimer's disease, within the PPMI initiative of the Michael J. Fox foundation for the study of Parkinson's disease. In addition, other databases were used such as that of the Virgen de la Victoria Hospital, Mlaga, Spain, and Virgen de las Nieves Hospital, Granada, Spain.

The research studies were financed by the Andalusian Regional Government through its excellence research program calls TIC-4530, TIC-2566 and TIC-7103. Additional funds were granted by the Spanish National R&D Plan call TEC2008-02113 and "DiagnoSIS" TEC2012-34306. The research group has been awarded several prizes as the University of Granada Premio del Consejo Social and the Andalusian Regional Government's Premio Andaluca Sociedad de la Informacin.

This research group has published more than 40 papers indexed in the ISI-JCR in the field of diagnosis and scan imaging analysis. The last three papers devoted to the study of Parkinson's disease- have been published in the most prestigious journals in the field of neuroscience such as Medical Physics (impact index 3.075) and NeuroImage (impact index 5.985, N1 journal in its category).

Undestanding the behavior of brain functions in patients with Parkinson's disease

The introduction of SPECT imaging worldwide for the diagnosis of Parkinson's disease (PD) based on the innovative DaTSCAN agent has allowed experts to better understand the behavior of behavior of brain functions in patients diagnosed with Parkinson's disease. The data provided by SPECT images can be processed by pattern-recognition machine, which allow an objective analysis of data.

A collaborative work with Virgen de la Victoria Hospital

The latest study conducted by this research group (Automatic assistance to Parkinson's disease diagnosis in DaTSCAN SPECT imaging. I. A. Illn, J. M. Grriz, J. Ramrez, F. Segovia, J. M. Jimnez-Hoyuela, and S. J. Ortega Lozano Med. Phys. 39, 5971 (2012)) presents a computer procedure that does not need the intervention of an expert (normalization, location of relevant regions, "clinical eye"...). In addition, this new technique systematically analyzes the effect of the different elements involved in the building process of the computer-assisted diagnosis technique on the accuracy of the final diagnosis. As a result, the technique proposed may exceed 90% of accuracy in the diagnosis of PD with the right selection of elements, and with the additional advantage of being a robust and simple computer software.

Similarly, the researchers at the research group SiPBA TIC 218 recently published the paper Improved Parkinsonism diagnosis using a partial least squares based approach. (F. Segovia, J. M. Grriz, J. Ramrez, I. lvarez, J. M. Jimnez-Hoyuela, and S. J. Ortega, Med. Phys. 39, 4395. 2012), an enhanced versin of the former paper with the same title. In this paper, researchers propose a method consisting on separating brain hemispheres to fulfill two goals: firstly to correctly diagnose AD when it only affects one hemisphere (in many patients, PD evolves asymmetrically during the first stages)

A Paper Accepted for the Prestigious Journal Neuroimage

The group SiPBA has also developed a method for the linear normalization of intensity of FP-CIT SPECT-type brain images, which are generally used in the diagnosis of PD. The method proposed is based on experimental evidence that the histogram of image intensity values can be accurately adjusted using only four parameters through asymmetric Levy-stable distributions.

In this study, stable-distribution parameters, concretely those of scale and position, are used to linearly convert the intensity values for each voxel. This conversion is performed in such a way that the new intensitivy histograms for each brain image have the same values for the parameters position and dispersion. The proposed method has a better performance that the traditional intensity normalization method, which is based on the ration between the intensity values of specific and non-specific brain regions.

This paper, titled Linear intensity normalization of FP-CIT SPECT brain images using the alpha-stable distribution, D. Salas-Gonzalez, J. M. Grriz, J. Ramrez, I. A. Illn, E.W. Lang, and the Parkinson's Progression Markers Initiative (PPMI), has been recently accepted for publication in the journal Neuroscience, which is the top journal in the Thomson/ISI ranking, with 5,898 impact points.


'/>"/>

Contact: Juan Manuel Grriz Sez
gorriz@ugr.es
34-958-243-271
University of Granada
Source:Eurekalert

Related medicine news :

1. The Tennessee Car Accident Lawyers at Michael D. Ponce & Associates Alert Public of CDC Survey Revealing Majority of High School Seniors Admitting to Texting Behind Wheel
2. Dr. Arthur Slutsky, vice-president of research at St. Michaels, receives lifetime award
3. Dr. Taub to give Estabrook Research Lecture at Kessler Foundation on Nov. 28
4. Edith Sanford Breast Cancer Foundation and TSRI partner in genomic breast cancer research
5. Kessler Foundation scientists awarded New Jersey grants for brain injury research
6. Research prizes from the Carlsberg Foundation to researchers from University of Copenhagen
7. Kessler Foundation scientist garners best poster award for MS research
8. Dr. Chiaravalloti of Kessler Foundation comments on trends in rehabilitation research in MS
9. Kessler Foundation presents Brain Injury: From Research to Rebuilding Lives on Sept. 27-28
10. CU study awarded grant from Moore Foundation
11. Society of Interventional Radiology Foundation: Medical students will make a difference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/21/2017)... ... February 21, 2017 , ... Robins ... Clinic in Durant, Oklahoma, on Feb. 21. , The celebration began with a ... members, clinic employees, the construction team and tribal leadership. , Choctaw Nation ...
(Date:2/21/2017)... ... ... Doctors on Liens has announced the addition of Mendonca Spine Care Center ... network of doctors in Central and Northern California. Dr. Mendonca specializes in personal injury ... pain, neck pain, hip and knee pain, and headaches. Specializing in non-surgical, spinal ...
(Date:2/21/2017)... ... February 21, 2017 , ... Ray Insurance Agencies, a Dallas area firm providing ... is embarking on a six month charity event aimed at raising local support and ... is one of the deadliest diseases in America; more than 7.5 million people die ...
(Date:2/21/2017)... ... February 21, 2017 , ... ... announced the further expansion of its eHealth App xChange™, providing clinical researchers ... of Bioclinica’s extensive and growing eHealth platform. Applications that enable patient-centered clinical ...
(Date:2/21/2017)... (PRWEB) , ... February 21, 2017 , ... ... with over 50,000 participants. The connected care demonstration spanned multiple health information ... National Coordinator, roughly 30% of providers have no Health Information Exchange outside of ...
Breaking Medicine News(10 mins):
(Date:2/21/2017)... 21, 2017 Mass Spectrometer Market: Overview ... This report on mass spectrometer ... prospects of the market globally. The stakeholders of ... the manufacture and commercialization of various mass spectrometer ... planning to enter this market. This report comprises ...
(Date:2/21/2017)... -- Luminex Corporation (NASDAQ: LMNX ) (the "Company") today ... of a quarterly cash dividend to its shareholders, the first ... payable on April 14, 2017 to shareholders of record as ... The board of directors intends for the Company ... holders of its common stock, representing a planned annual dividend ...
(Date:2/21/2017)... Feb. 21, 2017  Global health services company Cigna ... ® for breast reconstruction surgery and Dermacell ... an advanced acellular dermal matrix developed by LifeNet Health ... NVDQ ) "We are proud ... health-care payers to review the growing base of evidentiary ...
Breaking Medicine Technology: