Navigation Links
UGA scientists team up to define first-ever sequence of biologically important carbohydrate
Date:10/18/2011

ntities of protein for study.

Carbohydrates, however, are a bit messier. Scientists don't fully understand how cells create them, and a given proteoglycan exists in multiple forms that are similar but not quite the same.

The researchers chose the simplest known GAG proteoglycan, a compound known as bikunin that is used in Japan for the treatment of acute pancreatitis, for their study. Of course, simplicity is a relative term: the sugar is composed of up to 55 distinct carbohydrate rings, which means that there are 210 billion different sequence possibilities. Previous studies performed over the past five years by the researchers that identified common sequences within the carbohydrate decreased the expected number of sequences to a mere 43 million.

Past attempts to sequence proteoglycans have relied on the so-called "bottom up" approach in which scientists use enzymes to chop a molecule into its component parts and then try to put it back together, like a puzzle. Using an alternative approach known as the "top down" method, the scientists placed the compound into high-powered mass spectrometers in both the Amster and Linhardt labs that allowed them to break the compound in predictable places. With larger puzzle pieces to work with, the scientists were able to deduce the structure of bikunin.

"Now that we have demonstrated that bikunin, a small chondroitin sulfate proteoglycan, has sequence, we are moving on to larger, more structurally complex dermatan sulfate and heparan sulfate proteoglycans," said study co-author Robert Linhardt, professor at Rensselaer Polytechnic Institute. "These show important biological activities in development and in cancer, and we are optimistic that our sequencing approach will work here as well."

Like all groundbreaking scientific discoveries, the finding actually raises more questions than it answers. Amster explained that the addition of sulfate to the sugar, for example, could in principl
'/>"/>

Contact: Sam Fahmy
sfahmy@uga.edu
706-542-6049
University of Georgia
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Scientists in Singapore and Europe to collaborate
2. Scientists Spot New Clues to HIV-Linked Dementia
3. Scientists Engineer Mice That Have Autism
4. Raw Sewage a New Frontier for Scientists
5. Cedars-Sinai scientists, physicians to be key presenters at World Stem Cell Summit
6. 2 scientists at the University of Texas at Austin receive early career awards from White House
7. Scientists shut down pump action to break breast cancer cells drug resistance
8. President Barack Obama recognizes outstanding scientists at the Smithsonian
9. U.S. Scientists Map Genome of Advanced Prostate Cancer
10. Scientists ID More Genes Linked to Heart Disease
11. UCLA scientists find H1N1 flu virus prevalent in animals in Africa
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... (HealthDay News) -- Prostate cancer patients are more likely ... treatment and die sooner if they also have depression, ... more than 41,200 American men who were diagnosed with ... them through 2009. Nearly 1,900 of the patients had ... their prostate cancer was discovered. "Men with intermediate- ...
(Date:7/11/2014)... Riverside Health System became the first provider of ... late 2012 and now, in partnership with Williamsburg Landing, will ... Williamsburg and Newport News region. , Also known as life ... independent older adults who wish to remain in their homes ... continuing care services as well as control over the cost ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 The ... NMR Spectroscopy, Chromatography, Electrophoresis, Surface Plasmon Resonance, X-ray ... Forecast to 2018", analyzes and studies the major ... Europe, Asia, and the Rest of the World ... growth in the past few years, mainly due ...
(Date:7/11/2014)... best available treatment for patients, from a range of ... taxpayers than the existing clinical trial process, a new ... out while he was a member of the Clinical ... at The University of Manchester,s Health eResearch Centre, published ... today (Friday 11 July) looked at the use of ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 With the ... in men seeking cosmetic surgery and hair transplant procedures, ... such an expansive range of medical tourism destinations, the ... plastic surgery costs and achieve the look they ... renowned as the top name in the medical tourism ...
Breaking Medicine News(10 mins):Health News:Depression May Make It Harder to Beat Prostate Cancer 2Health News:Riverside and Williamsburg Landing Partner to Offer First of Its Kind Service to Virginians Who Want to Age in Place 2Health News:Riverside and Williamsburg Landing Partner to Offer First of Its Kind Service to Virginians Who Want to Age in Place 3Health News:Riverside and Williamsburg Landing Partner to Offer First of Its Kind Service to Virginians Who Want to Age in Place 4Health News:Proteomics Market Worth $20,696.4 Million by 2018 - New Report By MarketsandMarkets 2Health News:Proteomics Market Worth $20,696.4 Million by 2018 - New Report By MarketsandMarkets 3Health News:Proteomics Market Worth $20,696.4 Million by 2018 - New Report By MarketsandMarkets 4Health News:Better use of electronic health records makes clinical trials less expensive 2Health News:VisitandCare.com Reports Increase in Cosmetic and Hair Transplant Procedures for Men 2Health News:VisitandCare.com Reports Increase in Cosmetic and Hair Transplant Procedures for Men 3
... 3 (HealthDay News) -- The brain,s so-called reward center actually ... experiences causing fear, finds a new study in mice. ... may help explain why some people are thrill-seekers. Pleasurable ... off a bridge, can trigger the production of dopamine, a ...
... discovered that a natural product isolated from a traditional Chinese ... gong teng, and used for hundreds of years to treat ... machinery in the cell. The report, published as a cover ... suggests that the natural product could be a starting ...
... By Alan Mozes HealthDay Reporter , THURSDAY, ... of your computer hour after hour may well have its ... include dry, tired eyes, blurred vision, fatigue and headaches. ... but eye experts don,t agree on whether it,s serious or ...
... School of Medicine have found that lactate, a type of ... the formation of long-term memory. These findings have important implications ... memory impairment and diabetes. The research is published in the ... The study is the first to closely evaluate the role ...
... Using recent advances in genomics, researchers have uncovered a genetic ... could help predict which patients are at risk of relapse ... or "turned on" in breast cancer, research led ... several members of the E2F family of genes, which control ...
... cancer, lung cancer, breast cancer or prostate cancer. The study ... by 25 per cent after the cancer diagnosis. , ... and an increased workload that places a strain on one,s ... diagnoses of mental illnesses such as depression. However, there was ...
Cached Medicine News:Health News:Solving a traditional Chinese medicine mystery 2Health News:Solving a traditional Chinese medicine mystery 3Health News:Computer Vision Syndrome: Fact or Fiction? 2Health News:Computer Vision Syndrome: Fact or Fiction? 3Health News:Researchers find new mechanism behind the formation and maintenance of long-term memories 2Health News:Researchers pinpoint genetic pathways involved in breast cancer 2Health News:Cancer patients' partners become ill themselves 2
(Date:7/10/2014)... SAN DIEGO , July 10, 2014  RESMED INC. ... report its fourth quarter and fiscal year ended June 30, ... York Stock Exchange market close. A press release with ResMed,s ... and the company will host a webcast to discuss operating ... scheduled to begin at 1:30 p.m. US Pacific Time and ...
(Date:7/10/2014)... July 10, 2014  Valeant Pharmaceuticals International, Inc. (NYSE: ... it has completed the sale to Galderma of all ... or held by Valeant for $1.4 billion in cash, ... which recently completed its acquisition of Galderma. ... our products to a company that is firmly committed ...
(Date:7/10/2014)... , July 10, 2014   LabStyle ... Management Solution, today announced the appointment of Professor ... member of its Board of Directors. ... and business experience to LabStyle as an entrepreneur, ... legal and corporate governance expert. He currently serves ...
Breaking Medicine Technology:ResMed To Announce Fourth Quarter And Fiscal Year-End 2014 Results 2LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 2LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 3LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 4
... Nile Therapeutics,Inc. (Nasdaq: NLTX ), today announced ... failure patient in its Phase IIa, multi-center, open-label,ascending ... candidate,CD-NP, a novel chimeric natriuretic peptide, in development ... The primary objective of the Phase IIa study ...
... 10 Medarex, Inc.,(Nasdaq: MEDX ) today ... in research discovery and antibody development, and the,multiple ... value.,In addition, comprehensive updates on current and future ... were presented by Medarex,s,President and CEO, Howard H. ...
Cached Medicine Technology:Nile Therapeutics Announces Dosing in Phase IIa Study of CD-NP in Heart Failure Patients 2Nile Therapeutics Announces Dosing in Phase IIa Study of CD-NP in Heart Failure Patients 3Medarex Highlights Strength in Antibody Development and Underlying Pipeline Strategy at R&D Day Event in New York City 2Medarex Highlights Strength in Antibody Development and Underlying Pipeline Strategy at R&D Day Event in New York City 3Medarex Highlights Strength in Antibody Development and Underlying Pipeline Strategy at R&D Day Event in New York City 4Medarex Highlights Strength in Antibody Development and Underlying Pipeline Strategy at R&D Day Event in New York City 5Medarex Highlights Strength in Antibody Development and Underlying Pipeline Strategy at R&D Day Event in New York City 6
... Access ...unlike any trocar system you've ever ... actually four systems in one designed ... adaptive to all of your needs., ... or dilating tip styles, OnePort™ can effectively ...
... line of Surgical Access ...unlike any trocar ... trocar system is actually four systems in ... flexible and clinically adaptive to all of ... disposability and bladed or dilating tip styles, ...
... FPK01 Thoracic Trocar Pak contains: ... flexible sleeves and (1) 12mm ... ,FPK02 Thoracic Trocar Pak contains: ... flexible sleeves., ,FPK03 Thoracic ...
... The FLEXIPATH Flexible Surgical ... solid or mechanical obturator and ... designed to prevent puncture or ... flexible sleeve has securing holes ...
Medicine Products: