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UGA researchers discover new method to reduce disease-causing inflammation
Date:6/16/2014

cells commonly associated with autoimmune disease are able to accumulate at inflamed tissues where they can attack healthy tissue.

While reducing Tpl2 expression may ease the burden of many painful and debilitating disorders, it also weakens the immune system, making it harder for the body to fight off bacteria, viruses, parasites and cancerous cells.

"A number of laboratories throughout the world have researched the inhibition of chemokine receptors as a potential therapy for a variety of disorders," Watford said. "We still face a number of hurdles, but we hope that this may one day serve as the foundation for a new approach to disease treatment."

The research group is planning additional tests using mouse models that mimic the symptoms of rheumatoid arthritis to see if Tpl2 inhibition will reduce inflammation and ease symptoms.

"This is an emerging field," Watford said. "We have a lot of work to do, but many of our preliminary results are promising."


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Contact: Wendy Watford
watfordw@uga.edu
706-542-4585
University of Georgia
Source:Eurekalert

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