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UGA researchers discover new method to reduce disease-causing inflammation
Date:6/16/2014

Athens, Ga. Researchers at the University of Georgia report in the Journal of Biological Chemistry that an enzyme known as Tumor Progression Locus 2, or Tpl2, plays a key role in directing and regulating several important components of the body's immune system. Their discovery may one day lead to new treatments for many common autoimmune diseases.

"We know that immune dysfunction plays a serious role in a number of conditions, and we need better methods for controlling chronic inflammation," said Wendy Watford, assistant professor of infectious diseases in UGA's College of Veterinary Medicine and principal investigator for the study. "Our laboratory is searching for ways to disrupt the fundamental cellular processes that cause inflammation and disease."

The human immune system is an extraordinarily complex system of cells, proteins, tissues and organs that, when everything works properly, search out and destroy disease-causing toxins and pathogens like bacteria and viruses. But sometimes it becomes confused, and the microscopic troops that normally attack only invaders turn their weapons on healthy tissues.

The resulting inflammation caused by wayward defense cells is associated with a number of autoimmune diseases and conditions, including diabetes, obesity, depression, heart disease, stroke, respiratory disease and certain cancers.

Watford and her colleagues conducted tests with genetically modified mice lacking the Tpl2 enzyme in which they stimulated the animal's immune system and observed the behavior of several proteins known as chemokine receptors.

Chemokines act like a dispatcher, alerting the immune system's army of white blood cells to potential threats and directing them to problem areas.

The researchers found activity of three chemokine receptorsknown as CCR1, CCR2 and CCR5were reduced in Tpl2 negative mice. With these proteins operating at reduced capacity, fewer of the white blood
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Contact: Wendy Watford
watfordw@uga.edu
706-542-4585
University of Georgia
Source:Eurekalert

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