Navigation Links
UGA researchers boost efficacy of drugs by using nanoparticles to target 'powerhouse of cells'
Date:9/19/2012

Athens, Ga. - Nanoparticles have shown great promise in the targeted delivery of drugs to cells, but researchers at the University of Georgia have refined the drug delivery process further by using nanoparticles to deliver drugs to a specific organelle within cells.

By targeting mitochondria, often called "the powerhouse of cells," the researchers increased the effectiveness of mitochondria-acting therapeutics used to treat cancer, Alzheimer's disease and obesity in studies conducted with cultured cells.

"The mitochondrion is a complex organelle that is very difficult to reach, but these nanoparticles are engineered so that they do the right job in the right place," said senior author Shanta Dhar, an assistant professor of chemistry in the UGA Franklin College of Arts and Sciences.

Dhar and her co-author, doctoral student Sean Marrache, used a biodegradable, FDA-approved polymer to fabricate their nanoparticles and then used the particles to encapsulate and test drugs that treat a variety of conditions. Their results were published this week in early edition of the journal Proceedings of the National Academy of Sciences.

To test the effectiveness of their drug targeting system against cancer, they encapsulated the drug lonidamine, which works by inhibiting energy production in the mitochondria, and, separately, a form of the antioxidant vitamin E. They then treated cultured cancer cells and found that mitochondrial targeting increased the effectiveness of the drugs by more than 100 times when compared to the drugs alone and by five times when compared to the delivery of drugs with nanoparticles that target the outside of cells.

Similarly, the compound curcumin has shown promise in inhibiting formation of the amyloid plaques that are a hallmark of Alzheimer's disease, but it quickly degrades in the presence of light and is broken down rapidly by the body. By encapsulating curcumin in the mitochondria-targeting
'/>"/>

Contact: Shanta Dhar
shanta@uga.edu
706-542-1012
University of Georgia
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UGA researchers boost efficacy of drugs by using nanoparticles to target 'powerhouse of cells'
(Date:7/9/2014)... Cancer Center paint a relatively optimistic picture of women,s ... have spread to the chest wall or skin, but ... skin, regardless of size and whether they have involved ... and called "locally advanced" tumors, suggesting that they are ... survival. Locally advanced breast cancers of this and other ...
(Date:7/9/2014)... -- Researchers from The Miriam Hospital have found ... who are also depressed have difficulty sticking to ... particularly true for women, and screening and brief ... of treatment. The study and its findings are ... , Chronic obstructive pulmonary disease is a ...
(Date:7/9/2014)... There has been a sharp increase in the number ... MyChart, the online, interactive service that allows patients to ... providers, schedule appointments, and renew prescriptions. , Over a ... MyChart each year increased five-fold, while the number ... according to a study by Dr. David Gerber ...
(Date:7/9/2014)... highlights, Brian Williams refreshing old school rap classics, and ... A University of Colorado Cancer Center study published in ... also allows researchers, journals, and health advocates to connect ... and prevention. , "No matter what field you,re in, ... around the world," says Chante Karimkhani, MD candidate in ...
(Date:7/9/2014)... of the most important organs in the human body. ... food properly this is its synthesis function ... this is its detoxification function. Lack of exercise ... damage the liver. The resulting diseased cells can lead ... liver failure. According to the German Liver Foundation, over ...
Breaking Medicine News(10 mins):Health News:Fox Chase researchers recommend updating the staging criteria for breast cancer diagnoses 2Health News:Fox Chase researchers recommend updating the staging criteria for breast cancer diagnoses 3Health News:Miriam Hospital study examines effect of depressed mood on pulmonary rehab completion 2Health News:MyChart use skyrocketing among cancer patients, UT Southwestern study finds 2Health News:MyChart use skyrocketing among cancer patients, UT Southwestern study finds 3Health News:Study of dermatology on YouTube shows new ways science reaches public 2Health News:Telemedicine for patients with chronic liver diseases 2Health News:Telemedicine for patients with chronic liver diseases 3
... Animation,s "Madagascar: Escape 2 Africa(TM)" Happy Meal(TM) Event, ... one minute of fun,each day to help make a difference ... is asking kids and families as it launches One,Minute to ... kids to see what a difference a minute can make. ...
... Enterprises, LLC (, http://www.CJPS-Enterprises.com ) announced today ... that depend on the automotive industry grow through,diversification ... seem similar in what they need from an,engineering ... embark,on this diversification initiative have been struggling to ...
... 2008Children born to mothers with pregnancy-related diabetes run twice ... research team directed by Professor Ginette Dionne of Universit ... published in the most recent issue of the scientific ... vocabulary and grammar skills of 221 children whose mothers ...
... Therapy for Cardiovascular Disease (IC3D) is a three-day ... cell-based therapies for treating cardiovascular diseases. The theme ... Building Blocks: Strategies for Cardiovascular Reconstruction in 2009." ... present basic, core discussions on stem cell science ...
... AUGUSTA, Maine, Nov. 6 Building on the ... for small businesses in Maine,the Maine State Chamber ... and Blue Shield have announced further additions to ... January, Chamber,BlueOptions will include eight health plans from ...
... Nov. 6 Today, at the annual,research conference of ... leading scientists discussed the state of the evidence on ... supplements are a $22 billion industry in the US. ... and concluded that,when it comes to cancer, dietary supplements ...
Cached Medicine News:Health News:McDonald's(R) Encourages Kids to Take One Minute to Move It 2Health News:McDonald's(R) Encourages Kids to Take One Minute to Move It 3Health News:McDonald's(R) Encourages Kids to Take One Minute to Move It 4Health News:CJPS Enterprises to Increase Focus on Automotive Diversification 2Health News:Pregnancy diabetes doubles the risk of language delay in children 2Health News:5th Annual Global Conference on Stem Cell Therapy to be held Jan. 13-16, 2009 in NYC 2Health News:Chamber BlueOptions Insurance Adds to its Options and Benefits for 2009 Suite of Insurance Plans Meeting Small Business Needs 2Health News:Chamber BlueOptions Insurance Adds to its Options and Benefits for 2009 Suite of Insurance Plans Meeting Small Business Needs 3Health News:Scientists Debate Dietary Supplements and Cancer Risk at AICR Conference 2
(Date:1/15/2014)...  A novel wearable injector slightly larger than an Oreo cookie ... self-inject prescription drugs in the large doses required to treat ... deficiencies, and genetic disorders.  An emerging biologic ... according to analysts.   Many of these drugs will require a ...
(Date:1/14/2014)... Brandeis Medical Center, led by Dr. Emmanuel Brandeis , offers ... tattoo removal experience with the advanced Astanza Duality laser and a ... cosmetic services with cutting edge medical technology and offering expert medical ... has seen a dramatic increase in the presence of tattoo ...
(Date:1/14/2014)... 14, 2014   NuAire , a manufacturer of ergonomically designed ... Hitachi Koki of Japan to sell ... America . NuAire will utilize its network of sales professionals ... Canada to offer assistance in application use, product benefits ...
Breaking Medicine Technology:Enable Injections Presents A New Class of Injectors for Drug Delivery at PEPTalk, Drug Delivery Partnership Meetings 2Beverly Hills Physician Features Tattoo Removal with the Astanza Duality Laser, Offers $99 Special 2NuAire announces sales and service of Hitachi Koki centrifuges in North America 2
... 2011 Hill-Rom Holdings, Inc. (NYSE: HRC ) ... January 26, 2011.  The company will host a webcast the ... EST. Earnings Release:   Hill-Rom,s Fiscal 2011 ... 2010, will be issued to the public after the close ...
... Amarin Corporation plc (Nasdaq: AMRN ) (the "Company"), ... today announced that it has completed its previously announced underwritten ... to the public of $7.60 per ADS. Due ... the company sold a total of 13,800,000 ADSs in the ...
Cached Medicine Technology:Hill-Rom Holdings, Inc. Hosts Fiscal 2011 First Quarter Earnings Webcast 2Amarin Announces Successful Completion of Offering of American Depositary Shares 2Amarin Announces Successful Completion of Offering of American Depositary Shares 3
Microscissors : Horizontal Scissors...
Disposable Microscissors: Vertical, 90...
Microscissors: Eckardt Vertical Retinomy Scissors...
... the original and very popular ... for cutting in the vertical ... curved tips allow greater versatility ... retlna. Tip is shaped like ...
Medicine Products: