Navigation Links
UGA chemistry discovery could have major medical implications
Date:9/11/2012

Athens, Ga. The study of an oxygen-sensing bacterial regulatory protein by chemistry researchers at the University of Georgia has provided molecular insight into the oxygen sensing mechanism, which could ultimately lead to a better understanding of the ageing process and new treatments for human diseases such cancer, Parkinson's and Alzheimer's.

Michael Johnson, a distinguished research professor of chemistry in the UGA Franklin College of Arts and Sciences, and Bo Zhang, a UGA chemistry doctoral candidate, have discovered that the fumarate and nitrate reduction regulatory protein, or FNR, in E. coli senses oxygen by a new type of reversible structural change in an iron-sulfur cluster. The work was carried out in collaboration with Nick Le Brun and coworkers from the University of East Anglia. The results were published Sept. 10 in the journal Proceedings of the National Academy of Sciences USA.

Iron-sulfur clusters are abundant biological cofactors that play crucial roles in almost all of fundamental life processes, including respiration, photosynthesis, nitrogen fixation, DNA replication and repair. "Everyone has trillions of iron-sulfur clusters associated with enzymes and proteins in their bodies," Johnson said. "The problem is that they readily degrade in the presence of oxygen and other species that are associated with oxidative stress, leading to loss of protein function."

The research conducted at UGA and UEA focused on FNR, which senses the presence of oxygen in the environment and "switches" off and on specific genes in pathogens, such as E. coli, when there is no oxygen presentconditions often found in the human intestinal tract. Oxygen is sensed by FNR via its iron-sulfur clusterthat undergoes conversion from one form to another, smaller one, thereby causing the protein to change shapethe "switch"and leading to the turning off of genes associated with growth without oxygen.

"E. coli can decide what lif
'/>"/>

Contact: Michael K. Johnson
mkj@uga.edu
706-542-9378
University of Georgia
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Heroes of Chemistry: Developed new drugs and technology to cut heating and cooling bills
2. Astex, CRT and the Institute of Cancer Research announce epigenetic drug discovery collaboration
3. Genetic discovery in Montreal for a rare disease in Newfoundland
4. Discovery May Improve Diagnosis of Alzheimers, Parkinsons
5. A vaccine for heart disease? La Jolla Institute discovery points up this possibility
6. SFU duos protein discovery links to cancer research
7. Life Sciences Discovery Fund makes company grants in health-related technologies
8. Evolutionary information improves discovery of mutations associated with diseases
9. Discovery improves understanding of early onset inflammatory disease
10. Discovery explains how cellular pathways converge to regulate food intake and body weight
11. New mouse model helps explain gene discovery in congenital heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... No matter how “lonely” a person may ... set of friends to be always there for them. However, ... concept of making new friends during adulthood : not ... taking care of one’s family to a near-slavish devotion to ... new person just is not the same as it was ...
(Date:8/20/2014)... 2014 Blaine Labs®, the creators ... RevitaDERM® Psoriasis Treatment to ease the redness, ... This all-in-one product was created to treat, moisturize, ... is powered by coal tar and formulated to ... effective ingredient. , RevitaDERM® Psoriasis Treatment is ...
(Date:8/20/2014)... First Choice Emergency Room , ... the United States, named Richard Daniels, DO the Medical ... , “We are pleased to announce that Dr. ... second facility in Pflugerville,” said Dr. James M. Muzzarelli, ... , Dr. Daniels received his undergraduate degree from Brigham ...
(Date:8/20/2014)... August 20, 2014 What to Do ... Locked Out of the Market, **FDAnews Webinar**, Sept. 11, ... http://www.fdanews.com/DoNowforUDI , Hospitals and other buyers of devices ... ineffective product tracking systems. , Complying with the FDA’s ... demands to implement UDI as soon as possible. ...
(Date:8/19/2014)... As moms and dads prepare their children to go ... normal routine of dropping their little ones off at daycare ... encourages them to use the opportunity to implement a ... Yarker explains, “Kids have small tummies, short attention spans, and ... food handouts, use snack time as another daily opportunity to ...
Breaking Medicine News(10 mins):Health News:‘How to Make Friends as an Adult by Just Being Yourself: Becoming a “People Person” In Three Steps or Less’ Gives Tips for Making Friends During Adulthood - Vinamy 2Health News:RevitaDERM® Psoriasis Treatment Now Available At Over 7,600 CVS/pharmacies 2Health News:First Choice Emergency Room Announces Dr. Richard Daniels as Medical Director of the Pflugerville – FM 685 Facility 2Health News:FDAnews Announces — What to Do Now for UDI: Don’t Lose Your Customers by Getting Locked Out of the Market Webinar, Sept. 9, 2014 2Health News:FDAnews Announces — What to Do Now for UDI: Don’t Lose Your Customers by Getting Locked Out of the Market Webinar, Sept. 9, 2014 3Health News:FDAnews Announces — What to Do Now for UDI: Don’t Lose Your Customers by Getting Locked Out of the Market Webinar, Sept. 9, 2014 4Health News:Child Nutritionist Kristen Yarker Wants Parents to Rethink Kids’ Snacks This Fall 2Health News:Child Nutritionist Kristen Yarker Wants Parents to Rethink Kids’ Snacks This Fall 3
... UP WITH CROSSFIT TRAINER ANDY PETRANEK TO TACKLE THE ... an Olympic medalist to the growing list of female ... Andrea Duran is part of a burgeoning movement of ... the same grueling, high-intensity workouts used to train the ...
... to Address Rising Health Costs and Lost Economic OpportunityWASHINGTON, ... to the nation last night, Ken Thorpe, Ph.D., Executive ... on the Obama Administration to address the tremendous cost ... spending priorities of the nation in the year ahead. ...
... Telehealth Solutions, Adds Accomplished Financial Executive to its Senior Management Team ... ... TeleCare, Inc. (ATI) announced that Michael A. Brodeur has joined the ... the development and application of video-based telehealth solutions to advance patient ...
... Feb. 25 Practicing Clinicians Exchange (PCE) has ... (NFA) to provide continuing education programs to nurse ... United States in 2009.The partnership is beneficial to ... nonprofit group dedicated to improving the quality of ...
... (March 1, 2009) Even in the best economic ... cancer screening receive the life-saving test. Those without health ... colorectal cancer screenings are even less likely to be ... Gastroenterological Association (AGA) is working to raise awareness of ...
... offering to over 30,000 MembersNew Agreement with Diversified ... the new Fitness Industry Sales ChannelFORT LAUDERDALE, Fla., ... ), and Diversified Health & Fitness, Inc. today ... promote eDiets, award-winning, fresh-prepared diet meal delivery service ...
Cached Medicine News:Health News:CrossFit: A Workout Fit for an Olympian 2Health News:Partnership Calls on President to Attack Budget-Busting Crisis of Chronic Disease 2Health News:American TeleCare, Inc. (ATI) Appoints Michael A. Brodeur as Chief Financial Officer 2Health News:American TeleCare, Inc. (ATI) Appoints Michael A. Brodeur as Chief Financial Officer 3Health News:Practicing Clinicians Exchange Forms Partnership With National Fibromyalgia Association 2Health News:Practicing Clinicians Exchange Forms Partnership With National Fibromyalgia Association 3Health News:Economy could reduce colorectal cancer screening rate 2Health News:eDiets.com(R) and Diversified Health & Fitness Announce New Strategic Marketing Partnership 2Health News:eDiets.com(R) and Diversified Health & Fitness Announce New Strategic Marketing Partnership 3Health News:eDiets.com(R) and Diversified Health & Fitness Announce New Strategic Marketing Partnership 4
(Date:8/19/2014)... , Aug. 19, 2014   Lincor Inc. ... patient experience technology to New Jersey ... five-year agreement, CarePoint Health will deploy Lincor,s PatientLINC ... Center, Christ Hospital and Hoboken University Medical Center. ... range of software solutions to help hospitals reach ...
(Date:8/19/2014)... 2014 /PRNewswire-iReach/ -- ChemImage founder and CTO, Patrick ... describing an innovative diagnostic procedure for the detection of ... on Disease (SPEC) conference in Krakow, Poland ... "Development of in vitro Diagnostics for Detection of Colorectal ... the conference poster session on Tuesday, August 19, 2014 ...
(Date:8/19/2014)... 2014 Research and Markets has announced ... Material, by Technology, by Application & by Region- Global Trends ... The demand for membranes is estimated to increase ... to $29.31 billion Membrane technology was first commercialized ... water filtration and kidney dialysis. In modern times, membranes find ...
Breaking Medicine Technology:Lincor Announces Agreement With CarePoint Health For State-Of-The-Art Patient Engagement Technology 2ChemImage Scientists Present Latest Developments for in vitro Detection of Colorectal Cancer Using Raman Molecular Imaging (RMI) at International Conference Focused on Biomedical Applications of Raman Spectroscopy 2Global Membranes (MF, RO, UF, Gas Separation, Dialysis, NF) Market - Forecasts to 2019 2
... Pa. , Feb. 4 Draeger is responding ... two anesthesia machines to the University of Miami for ... , Draeger, a global leader in mechanical ventilation, is providing 16 ... donation comes at the request of the University of Miami ...
... SAN ANTONIO , Feb. 4 ... 26th Annual Meeting provides early published data analyzing information ... as the Controlled Substances Utilization Review and Evaluation System ... likelihood of individuals receiving opioids from multiple providers or ...
Cached Medicine Technology:Draeger Donating Mechanical Ventilators and Anesthesia Machines to University of Miami - Aid for Haiti Earthquake Disaster 2New Research Gives Insight to the Frequency of 'Doctor Shopping' Occurring Within Prescription Monitoring Programs 2New Research Gives Insight to the Frequency of 'Doctor Shopping' Occurring Within Prescription Monitoring Programs 3
... iMRI is a neurosurgical OR that ... diagnostic tools, including iMRI, necessary to ... iMRI, neurosurgical treatments are performed in ... designed for MR compatibility and safety, ...
... Neuropack M1 is an advanced ... system. It is a sophisticated 2 ... MEB-2200. 2 electrical stimulations, 2 sound ... goggles stimulation. You can customize each ...
Every so often a new product comes along that isn't a small step but a giant leap ahead of everything that has preceeded it. Such is the impact of the Fidelity IAB....
... Dimension cardiovascular ultrasound system is the world's ... fully integrated real-time 4D and multi-dimensional imaging ... member of the Vivid 7 family, provides ... diagnosing heart conditions such as heart failure ...
Medicine Products: