Navigation Links
UGA, Emory to study how exercise may prevent drug abuse relapse
Date:4/29/2010

Athens, Ga. A team of researchers at the University of Georgia and Emory University will receive $1.9 million over the next five years from the National Institutes of Health to study the neurobiological mechanisms for how regular aerobic exercise may prevent drug abuse relapse.

"Drug abuse is closely linked to stress, and one of the most challenging aspects of treating addiction is preventing the relapse caused by stress," said Philip Holmes, professor of psychology in the Franklin College of Arts and Sciences and a co-investigator on the project. "Despite many years of research, no universal treatment to prevent relapse exists."

Previous research in Holmes' lab has demonstrated that exercise exerts anti-stress effects. A chemical called galanin, which increases in the brain during exercise, appears to reduce cravings associated with stress.

"Stress turns on norepinephrine," said Holmes, "which turns on dopamine, which induces craving. Galanin decreases norepinephrine, so someone with high levels of galanin should experience reduced cravings."

For the project, Holmes will measure exercise-induced increases of the galanin gene activity in the rat brain. "These experiments will establish the relationship between exercise and galanin gene expression, and support the hypothesis that exercise-induced regulation of galanin protects against over-activation of the norepinephrine system, thereby preventing drug self-administration following stress."

"This research will provide new insight into how regular exercise may attenuate drug abuse in humans," said David Weinshenker, associate professor of human genetics in Emory University's School of Medicine, and a co-principal investigator on the project. "More importantly, it may reveal a neural mechanism through which exercise may prevent the relapse into drug-seeking behavior."

Dr. Gaylen Edwards, professor and head of the department of physiology and pharmacology, UGA College of Veterinary Medicine, and Mark Smith, associate professor of psychology, Davidson College, Davidson, N.C., also will assist in the investigation.

The research may also lead to the development of drugs that enhance galanin for the treatment of addiction.

"Of course, the better alternative would be to naturally increase one's galanin levels through exercise," said Holmes, "but either way may help recovering addicts in stressful environments."


'/>"/>

Contact: Laurie Anderson
laurie@uga.edu
706-583-0599
University of Georgia
Source:Eurekalert

Related medicine news :

1. Memory Loss Supplement Manufacturer Partners With Nationally-Syndicated Radio Host John Tesh
2. To Boost Your Memory, Take a Break
3. Immune memory formation seen in early stages of viral infection
4. Brain scientists extend map of fear memory formation
5. Discovery of epigenetic memory during breast cancer
6. Study shows link between working memory and reactive parenting
7. Neuralstem Receives Approval To Commence First ALS Stem Cell Trial at Emory ALS Center
8. InfoZoom Launches V6.4 of its Industry Leading In-Memory Data Analysis Software
9. Healthy older adults with subjective memory loss may be at increased risk for MCI and dementia
10. €1.6 million ($2.32 million) grant awarded to Prof. Kobi Rosenblum for brain and memory research
11. The Run for the Memory Marathon Team Getting in Shape and Fighting Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... Cambridge, MA (PRWEB) , ... December 08, 2016 , ... ... decreases in medical payments per workers’ compensation claim in 2013 and 2014, according to ... Workers Compensation Research Institute (WCRI) . , According to the study, medical payments per ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... Care Act. Dr. Botelho advocates for the mass media launching of story movements ... ongoing opportunities to share their unfortunate experiences; such a movement can generate the ...
(Date:12/8/2016)... Rock, AR (PRWEB) , ... December 08, 2016 ... ... providing insurance and financial planning services from offices headquartered in Little Rock, has ... Food Pantry. , According to the National Foundation to End Senior Hunger, Arkansas ...
(Date:12/8/2016)... ... December 08, 2016 , ... The Dan ... headquartered in Jefferson County, is announcing the launch of a charity drive to ... number of homeless women and children in Birmingham has grown steadily since the ...
(Date:12/8/2016)... ... December 08, 2016 , ... Coppin Insurance Agency, an insurance and financial planning ... the Cape Coral area, is embarking on a charity drive with the goal of ... The Harry Chapin Food Bank of Southwest Florida works to provide fresh and nutritious ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... 2016  Diplomat Pharmacy, Inc. (NYSE: DPLO) has been recognized by ... Workplaces National Standard. To learn more about Diplomat,s ... ... ... administered by WorkplaceDynamics, LLC, a research firm specializing in organizational health ...
(Date:12/8/2016)... Connecticut , 8 de dezembro de 2016  A Mederi Therapeutics ... terapia Stretta, um tratamento não cirúrgico para a doença do refluxo gastroesofágico (DRGE). ... ... Live Stretta procedure performed and ... of Endoscopy at Wuhan Union Hospital ...
(Date:12/8/2016)... Pa. , Dec. 8, 2016  A new ... reports that the use of opioid therapy to treat ... increase the likelihood of more harmful consequences, including death. ... , M.D., and Zankhana Mehta , M.D., authored ... research on chronic opioid therapy. The study was published ...
Breaking Medicine Technology: