Navigation Links
UF study finds brain-imaging technique can help diagnose movement disorders
Date:6/13/2013

GAINESVILLE, Fla. A new University of Florida study suggests a promising brain-imaging technique has the potential to improve diagnoses for the millions of people with movement disorders such as Parkinson's disease.

Utilizing the diffusion tensor imaging technique, as it is known, could allow clinicians to assess people earlier, leading to improved treatment interventions and therapies for patients.

The three-year study looked at 72 patients, each with a clinically defined movement disorder diagnosis. Using a technique called diffusion tensor imaging, the researchers successfully separated the patients into disorder groups with a high degree of accuracy.

The study is being published in the journal Movement Disorders.

"The purpose of this study is to identify markers in the brain that differentiate movement disorders which have clinical symptoms that overlap, making [the disorders] difficult to distinguish," said David Vaillancourt, associate professor in the department of applied physiology and kinesiology and the study's principal investigator.

"No other imaging, cerebrospinal fluid or blood marker has been this successful at differentiating these disorders," he said. "The results are very promising."

Movement disorders such as Parkinson's disease, essential tremor, multiple system atrophy and progressive supranuclear palsy exhibit similar symptoms in the early stages, which can make it challenging to assign a specific diagnosis. Often, the original diagnosis changes as the disease progresses, Vaillancourt said.

Diffusion tensor imaging, known as DTI, is a non-invasive method that examines the diffusion of water molecules within the brain and can identify key areas that have been affected as a result of damage to gray matter and white matter in the brain. Vaillancourt and his team measured areas of the basal ganglia and cerebellum in individuals, and used a statistical approach to predict group classification. By asking different questions within the data and comparing different groups to one another, they were able to show distinct separation among disorders.

"Our goal was to use these measures to accurately predict the original disease classification," Vaillancourt said. "The idea being that if a new patient came in with an unknown diagnosis, you might be able to apply this algorithm to that individual.

He compared the process to a cholesterol test.

"If you have high cholesterol, it raises your chances of developing heart disease in the future," he said. "There are tests like those that give a probability or likelihood scenario of a particular disease group. We're going a step further and trying to utilize information to predict the classification of specific tremor and Parkinsonian diseases."

Vaillancourt and his team are part of the National Institute of Neurological Disorders and Stroke Parkinson's Disease Biomarkers Program, an effort that was launched in 2012 and awarded nine grants to scientists across the U.S., totaling more than $5 million in the first year. The program gives researchers access to a much broader community of individuals and patients as part of a biomarker initiative for Parkinson's disease.

Vaillancourt's team is engaged in a longitudinal study at UF that will assess between 150 and 180 people over the next few years. His team will be using DTI as well as other MRI-based techniques to classify subjects and track their progression, he said.


'/>"/>

Contact: Allison Vitt
avitt@hhp.ufl.edu
352-294-1609
University of Florida
Source:Eurekalert

Related medicine news :

1. First major study of suicide motivations to advance prevention
2. Insurance Service Center Discusses a Recent Health Study and Encourages the Wisconsin Community to Purchase Adequate Health Coverage to Avoid a Financial Disaster
3. Study Identifies Most Effective Natural Bed Bug Killer
4. Clearwater, FL Periodontist, Dr. Stephen Kobernick Cites Recent Periodontal Study Urging Patients to Seek Gum Disease Treatment
5. Self-defense training for Kenyan girls reduces rape, Stanford/Packard study finds
6. Study finds greater potential benefit in overall survival for eribulin compared with capecitabine
7. New Study Links Poor Sleep and Prostate Cancer
8. Researcher awarded grant to study food insecurity in homes of child with special healthcare needs
9. Study finds cancer guidelines do not fully meet IOM standards
10. Our Lady of Lourdes Medical Center & The Heart House Participating in Research Study Using Adult Stem Cells for Chronic Cardiac Condition
11. High Bit Security: 2/3 of All Data Breaches Preventable With Proactive Security Testing, New Ponemon Institute Study Documents Breach Causes and Costs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/16/2017)... ... 2017 , ... Ten outstanding teachers in the Greater Houston area will be ... a visit by a Houston Texans player, two tickets to a Texans game, and ... can visit texanschecking.com/stars to nominate their favorite teacher with an essay of no more ...
(Date:8/16/2017)... ATLANTA, Georgia (PRWEB) , ... August 16, 2017 ... ... practice in Atlanta, opened their doors. They celebrate 30 years in business this ... to create an up-to-date, inviting, tranquil space to serve their patients. , ...
(Date:8/16/2017)... ... August 16, 2017 , ... Maury Regional Health has announced ... draws. By broadly deploying AccuVein devices, Maury Regional Medical Center is making vein visualization ... out of a needle stick and more importantly, helps our staff members locate a ...
(Date:8/16/2017)... ... ... A global leader in the treatment of clubfoot, CURE International India ... the country one step closer to eliminating clubfoot as a lifelong disability by 2030. ... to enroll 10,000 children in the clubfoot treatment program in this year alone. , ...
(Date:8/16/2017)... Georgia (PRWEB) , ... August 16, 2017 , ... Fusion ... distribute premium original programming over four countries and millions of viewers in a partnership ... to rent or buy On-Demand and fully available on Blu Ray disc in 2018. ...
Breaking Medicine News(10 mins):
(Date:8/3/2017)... , Aug. 3, 2017  Opioid addiction and ... driving up healthcare costs and threatening outcomes, were problems ... supply and IVD industry that support them, met this ... market researcher said that drugs of abuse, procalcitonin and ... sessions at the organization,s 69th meeting in ...
(Date:8/2/2017)... CaryRx, a next-generation full-service pharmacy, has announced the ... in the Washington D.C. metropolitan area. ... delivery of medications through the convenience of its patient-friendly mobile ... within one hour to any location in D.C. ... invaluable service to Washington D.C. ," says ...
(Date:7/31/2017)... 7D Surgical, developer of ground breaking surgical navigation technologies, announced ... to support its strategic sales plan in Maryland ... 7D Surgical has entered into an exclusive sales representative agreement ... within those markets. ... Spartan Medical Purchases 7D Surgical ...
Breaking Medicine Technology: