Navigation Links
UF researchers track genetic journey of HIV from birth to death
Date:10/16/2007

GAINESVILLE, Fla. --- University of Florida scientists have discovered how HIV evolves over the course of a persons lifetime into a more deadly form that heralds the onset of full-blown AIDS. The findings could pave the way for new therapeutic agents that target the virus earlier in the disease process, before it takes a lethal turn, researchers say.

We were very interested in understanding how the virus mutates from the beginning of the infection until the end, said Marco Salemi, an assistant professor of pathology, immunology and laboratory medicine in the UF College of Medicine and lead author on the study, which appeared in an online issue of the journal PLoS ONE in September. Previously, the only thing known was that somehow the HIV population mutates. And as soon as that happens, patients start developing AIDS. But no one knew how and where the population evolved over time.

To find out, UF researchers began tracking four children born with HIV, studying blood samples taken at birth, throughout life and just after death, when tissues samples were also taken. Using a high-resolution computational technique, they monitored mutations in a protein that helps HIV attach to human cells and then categorized the virus into two groups, R5 and X4. The R5 population is usually present in high numbers during the early stages of infection. But the X4 population enters the scene later, just before HIV gives way to full-blown AIDS. The researchers tracked the viruses in each patient to find out when and where the telltale X4 population first appeared.

The general dogma has always been that the X4 viruses are more pathogenic than the R5 viruses. And that really isnt true. People die from the R5 viruses, said Maureen Goodenow, senior author of the paper and the Stephany W. Holloway university chair for AIDS research in the UF College of Medicine. But certainly evolution of these X4 viruses is not a good prognostic indicator. So if we could under
'/>"/>

Contact: Ann Griswold
anngriswold@gmail.com
352-273-5819
University of Florida
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers identify the early makers of Neonatal Sepsis
4. OHSU Researchers Announce New Discovery
5. Researchers Identify Gene Connected To Bipolar Disorder
6. Ecstasy shrinks brain!!-researchers unveil the secrets of MDMA.
7. Researchers trick Alzheimers Enzyme
8. Researchers find new HIV hiding place
9. Gene researchers make Malaria-resistant mosquito
10. New Hair in 15 Days Could Now Be A Possibility Say Researchers
11. Researchers developed world’s smallest toothbrus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/3/2015)... ... 2015 , ... The new In-Office whitening kit from Whiter ... Clinicians Report is a leading information source to the dental industry. Product reviews ... Image's In-Office whitening kits were favorably validated for use in the dental office. ...
(Date:9/3/2015)... ... September 03, 2015 , ... Local filmmakers and now co-hosts of the ... from Path 11 Productions have had great success in launching their Path11 Podcast with ... House authors, Teal Swan who is the well known Spiritual Catalyst and Linda Howe, ...
(Date:9/3/2015)... Lagos (PRWEB) , ... September 03, 2015 , ... ... base, robust distribution channels and efficient customer and technical support services to promote ... NAFDAC approved 90-day Bridging trial evaluating the efficacy and safety of the product. ...
(Date:9/2/2015)... ... 03, 2015 , ... One can hardly argue against the fact that more ... and personal computers. These devices are being used as GPS, to make purchases, and ... dating apps, STD positive singles can now join the prestigious social ranks of e-dating. ...
(Date:9/2/2015)... (PRWEB) , ... September 02, 2015 , ... Chris Harrison ... September 2015. “It was a simple decision, really,” says Chris. “We have a lot ... They know the brands that work best for them—so we’ve given them the convenience ...
Breaking Medicine News(10 mins):Health News:Whiter Image Products Get Positive Rating From The Clinicians Report 2Health News:Path 11 Podcast Now Features over 20 Metaphysical Discussions on iTunes and Growing 2Health News:Path 11 Podcast Now Features over 20 Metaphysical Discussions on iTunes and Growing 3Health News:Fidson Partners US Firms on New Product Marketing 2Health News:Fidson Partners US Firms on New Product Marketing 3Health News:Fidson Partners US Firms on New Product Marketing 4Health News:Herpes-datingsites.com Recently Added Reviews of 5 STD Dating Apps for STD Positive Singles 2Health News:Harrison's Comfort Footwear Announces Expansion with New CHarrison Online Store 2
... prehypertensive people in morning use, researchers report , , WEDNESDAY, ... control prehypertension, but only if it is taken at ... every morning didn,t lower the blood pressure of prehypertensive ... Hermida reported Wednesday at the American Society of Hypertension ...
... May 14 AstraZeneca (NYSE:,AZN) today announced that ... SEROQUEL(R) (quetiapine fumarate tablets) for the maintenance,treatment of ... to,lithium or divalproex. SEROQUEL is approved by the ... the only single agent approved by the FDA ...
... Amarin Corporation plc,(NASDAQ: AMRN ) today announced ... one ordinary share) ("ADSs") with several new,institutional and ... for up to $60 million funded over two ... entered into definitive agreements for,gross proceeds of up ...
... FRAMINGHAM, Mass., and SYDNEY, Australia, May 14 /PRNewswire-FirstCall/,-- HeartWare ... to,make an investor presentation at the Seventh Annual JMP ... on Wednesday, May 21, 2008. The,conference is being held ... live webcast of the Company,s presentation at the conference ...
... -- Mindray,Medical International Limited (NYSE: MR ), ... in China with a rapidly growing,international presence, today ... of strategic development and Ms. May Li, Mindray,s,investor ... Annual,China Dragon Call Conference to be held at ...
... Families Raise Preschoolers to Be Healthy,Eaters, SACRAMENTO, ... years old experience developmental changes that affect their ... these changes,families can help turn their preschoolers into ... ), According to Monica Montes, a ...
Cached Medicine News:Health News:Aspirin at Bedtime Lowers Blood Pressure 2Health News:FDA Approves AstraZeneca's Seroquel(R) for Maintenance Treatment in Bipolar Disorder 2Health News:FDA Approves AstraZeneca's Seroquel(R) for Maintenance Treatment in Bipolar Disorder 3Health News:FDA Approves AstraZeneca's Seroquel(R) for Maintenance Treatment in Bipolar Disorder 4Health News:FDA Approves AstraZeneca's Seroquel(R) for Maintenance Treatment in Bipolar Disorder 5Health News:FDA Approves AstraZeneca's Seroquel(R) for Maintenance Treatment in Bipolar Disorder 6Health News:FDA Approves AstraZeneca's Seroquel(R) for Maintenance Treatment in Bipolar Disorder 7Health News:FDA Approves AstraZeneca's Seroquel(R) for Maintenance Treatment in Bipolar Disorder 8Health News:FDA Approves AstraZeneca's Seroquel(R) for Maintenance Treatment in Bipolar Disorder 9Health News:Amarin Announces Private Placement for up to $60 Million 2Health News:Amarin Announces Private Placement for up to $60 Million 3Health News:Amarin Announces Private Placement for up to $60 Million 4Health News:Amarin Announces Private Placement for up to $60 Million 5Health News:HeartWare to Present at Seventh Annual JMP Securities Research Conference 2Health News:Mindray to Present at the Oppenheimer 2nd Annual China Dragon Call Conference and 2008 Citi Investment Research Global Healthcare Conference 2Health News:Learning Good Eating Habits Early Leads to Lifelong Health and Wellness 2
(Date:9/2/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/6x789c/new_eu ) ... Pharmacovigilance Legislation (London, UK - November 16-17, 2015)" ... new EU modules concerning Pharmacovigilance are a major departure ... Europe . The intention of the ... requirements, examine how they overlap and fit together and ...
(Date:9/2/2015)... -- Demers Ambulances is proud to announce it has signed ... the states of Mississippi , ... "This will enable Demers to effectively meet the ... Vice-President for Demers Ambulances. "Emergency Equipment Professionals has three service ... Alabama , giving them a strategic advantage. Local ...
(Date:9/2/2015)... Fla. , Sept. 2, 2015  Boca ... MD, FACS, has begun performing ultra-minimally invasive left ... are on anticoagulants such as Coumadin, Xarelto or ... Surgery at the Hospital, is one of a ... which involves making two microscopic incisions in order ...
Breaking Medicine Technology:Demers Ambulances has named Emergency Equipment Professionals (EEP) Inc. as their dealer for the states of MS, AL and TN 2Boca Regional Introduces Ultra-Minimally Invasive Surgical Procedure for Atrial Fibrillation Patients 2Boca Regional Introduces Ultra-Minimally Invasive Surgical Procedure for Atrial Fibrillation Patients 3
... The combination of these recommendations with the ... Sorin Group has resulted in numerous improvements, ... poles and reservoir holder for hassle-free storage ... cart with just a flick of the ...
The S4 Spinal System has quickly gained a reputation for being the next generation in pedicle screw systems because of its exceptionally small size and high biomechanical strength....
... Diagnostics is a clinical reference ... treatment and monitoring of hemostatic ... a collaboration of four laboratory ... defined vision to deliver customizable ...
All-natural porcine collagen can be used in open or laparoscopic placement....
Medicine Products: