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UF researchers test stem cell therapy for heart patients
Date:10/4/2007

GAINESVILLE, Fla. University of Florida doctors on Wednesday (Oct. 3) treated their first patient enrolled in a new study designed to test whether injecting stem cells into the heart helps restore blood flow to the organ by prompting new blood vessels to grow.

UF researchers plan to test the experimental therapy in people with severe coronary artery disease and daily chest pain who have not responded to traditional medications or surgical procedures designed to restore blood flow, such as angioplasty or bypass surgery.

The general idea is that by providing these cells of blood vessel origin, we hope to either generate new blood vessels from the growth of these implanted cells or stimulate the heart to regenerate new blood vessels from the cells that reside in it, said study investigator Carl J. Pepine, M.D., chief of cardiovascular medicine at UFs College of Medicine. Its not completely clear whether its the actual cell itself that would do this or whether its just the milieu and the chemical signals that occur from the cells that would result in this.

Each year, nearly half a million Americans with heart disease experience severe chest pain because coronary arteries and the smaller vessels that supply oxygen-rich blood to the heart muscle become narrowed or blocked by plaque deposits or clots. These blockages can trigger mini-heart attacks that, while too small to be noticed as they occur, over time irreversibly damage the heart leading to disability, progressive heart failure or even death.

In the prospective, double-blind, placebo-controlled study, known as the Autologous Cellular Therapy CD34-Chronic Myocardial Ischemia Trial, or ACT34-CMI, UF researchers will study 15 Shands at UF medical center patients to determine whether a persons own stem cells can be used to effectively and safely treat chronic reductions in blood flow to the heart, improving symptoms and long-term outcomes. They also will evaluate whether partic
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Contact: Melanie Fridl Ross
ufcardiac@aol.com
352-690-7051
University of Florida
Source:Eurekalert

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