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UD's Roberta Colman ranks in top 50 most prolific authors in Biochemistry
Date:6/27/2011

Roberta Colman, Willis F. Harrington Professor Emerita of Chemistry and Biochemistry at the University of Delaware, ranks 23rd in the journal Biochemistry's 50 most prolific authors. The journal, published by the American Chemical Society, is celebrating its 50th year of publication.

In "Celebrating 50 Years of Cutting-Edge Biochemical Science on the journal's website," editor-in-chief Richard N. Armstrong acknowledges the 50 most prolific authors, noting that "the readers and editors appreciate their long history of support and their choosing Biochemistry as a venue for publishing their science."

Armstrong points out that Biochemistry was launched in 1962 when science and technology in the United States were rapidly expanding. The journal's founding editor and all 12 associate editors were all either current or eventual electees to the National Academy of Sciences, and one became a Nobel Laureate.

Colman is one of only four women in the distinguished group of 50. She has published 79 research articles in Biochemistry so far, with the latest appearing in January 2011. To date, Colman has authored 264 articles in peer-reviewed scientific journals.

Colman's research has sought to understand the catalytic activity of enzymes in terms of protein structure work that has important implications for human health.

For example, the enzyme glutathione S-transferase (GST), which Colman has studied, plays an important role in detoxifying foreign chemicals (xenobiotics). Research has shown that the elevation of GST levels in solid tumors is a major factor in why cancer patients develop resistance to chemotherapy treatment.

Another focus of Colman's lab has been adenylosuccinate lyase (ASL). Deficiency of this enzyme in humans is associated with mental retardation, and autism. Colman has worked to understand the chemical and structural contributions to catalysis by normal ASL and the molecul
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Contact: Tracey Bryant
tbryant@udel.edu
302-831-8185
University of Delaware
Source:Eurekalert  

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