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UCSF team finds new source of immune cells during pregnancy
Date:12/16/2010

they used blood-producing stem cells to generate new cell lines from the two groups, the same divergence occurred.

"We realized they there are in fact two blood-producing stem cells, one in the fetus that gives rise to T cells that are tolerant and another in the adult that produces T cells that attack," Mold said.

Why that occurs, and why the immune system appears to switch over to the adult version sometime in the third trimester, remains unknown, McCune said. Further studies will attempt to determine precisely when that occurs and why, as well as whether infants are born with a range of proportions of fetal and adult immune systems information that could change the way we vaccinate newborns or treat them for such diseases as HIV.


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Contact: Kristen Bole
kristen.bole@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert  

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