Navigation Links
UCSF team finds new source of immune cells during pregnancy
Date:12/16/2010

system, by contrast, is programmed to attack anything it considers "other," which allows the body to fight off infection, but also causes it to reject transplanted organs.

"The adult immune system's typical role is to see something foreign and to respond by attacking and getting rid of it. The fetal system was thought in the past to fail to 'see' those threats, because it didn't respond to them," said Jeff E. Mold, first author on the paper and a postdoctoral fellow in the McCune laboratory. "What we found is that these fetal immune cells are highly prone to 'seeing' something foreign, but instead of attacking it, they allow the fetus to tolerate it."

The previous studies attributed this tolerance at least in part to the extremely high percentage of "regulatory T cells" those cells that provoke a tolerant response in the fetal immune system. At mid-term, fetuses have roughly three times the frequency of regulatory T cells as newborns or adults, the research found.

The team set out to assess whether fetal immune cells were more likely to become regulatory T cells. They purified so-called nave T cells new cells never exposed to environmental assault from mid-term fetuses and adults, and then exposed them to foreign cells. In a normal adult immune system, that would provoke an immune attack response.

They found that 70 percent of the fetal cells were activated by that exposure, compared to only 10 percent of the adult cells, refuting the notion that fetal cells don't recognize outsiders. But of those cells that responded, twice as many of the fetal cells turned into regulatory T cells, showing that these cells are both more sensitive to stimulation and more likely to respond with tolerance, Mold said.

Researchers then sorted the cells by gene expression, expecting to see similar expression of genes in the two cell groups. In fact, they were vastly different, with thousands of genes diverging from the two cell lines. When
'/>"/>

Contact: Kristen Bole
kristen.bole@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Second Brain Death Exam Unnecessary, Study Finds
2. Its True: Money Cant Buy Happiness, Study Finds
3. New research finds delaying surgical procedures increases infection risk and health care costs
4. Report Finds Baby Boomers to Gain Most From Health Care Reform
5. Kids Not So Stuck on Sugary Breakfast Cereals, Study Finds
6. Depression drug may relieve pain from breast cancer treatment, U-M study finds
7. Walkable Communities More Close-Knit, Study Finds
8. Critter Crossings Improve Highway Safety, Study Finds
9. Drug combination shows promise for newly diagnosed blood cancer patients, study finds
10. Weight-Lifting After Breast Cancer Wont Cause Lymphedema, Study Finds
11. Surgery complications linked to chemotherapy delay, U-M study finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UCSF team finds new source of immune cells during pregnancy
(Date:7/14/2014)... 14, 2014 Carepoint has been ... caregiving by combining an intuitive interface for recording, ... robust service tracking and reporting features. , Hall ... has teamed up with Rebecca de Witte to ... healthcare organizations. , Carepoint provides seamless, ...
(Date:7/14/2014)... 2014 Reha Technology today announced ... portable and full-featured upper extremity robotic trainer that ... interactive games and challenges in a lightweight and ... , Armotion combines a variety of ... maximize the therapy effect for patients with severe ...
(Date:7/14/2014)... Green Bay, WI (PRWEB) July 14, 2014 ... recently announced the launch of their new company ... to gather valuable free information on chiropractic marketing. It's ... the services that Inception has to offer. , When ... to release the newest version of our main website. ...
(Date:7/14/2014)... Beach, Calif. (PRWEB) July 14, 2014 ... protein bar and powder company Permalean for ... reputation. , Permalean, which markets its products ... Bars is now a part of EnergyFirst’s lineup ... integrated into EnergyFirst over the coming year. , Founded ...
(Date:7/14/2014)... 2014 Townsend Security, a leading ... new IBM i (AS/400, iSeries) Two Factor Authentication ... security threats evolve and make passwords ineffective for ... modernize their applications and implement two factor authentication ... easy for ISVs on the IBM i platform ...
Breaking Medicine News(10 mins):Health News:Home Health Care Professional and Marketing Firm Team Up to Create New Homecare Communication App 2Health News:Reha Technology Launches the Armotion™, a Device for the Rehabilitation of the Upper Extremity 2Health News:Doctor Mike Hamilton From Inception Chiropractic Websites Announces the Launch of Their New Website 2Health News:EnergyFirst Acquires Permalean - Manufacturer of All Natural Protein Bars and Powders 2Health News:EnergyFirst Acquires Permalean - Manufacturer of All Natural Protein Bars and Powders 3Health News:IBM i ISVs Can Now Easily Integrate Mobile-Based Two Factor Authentication to Increase Security of Solutions 2Health News:IBM i ISVs Can Now Easily Integrate Mobile-Based Two Factor Authentication to Increase Security of Solutions 3
... in halving the number of relapses experienced by people ... accounts for 12 per cent of suicides each year ... , With funding from the MBF Foundation and Beyond ... Institute of Victoria has developed an innovative structured group ...
... related costs increased 57% from 1999 to 2004, analysis shows ... been progress in the prevention and treatment of kidney failure ... a new analysis shows. , In 2004, the most recent ... 0.03 percent of the population) started dialysis or received a ...
... specializing in laparoscopic procedures at UT Southwestern Medical Center ... unique nephrectomy entirely through the belly button. , ... performed the single keyhole access surgery, the first of ... completed with only one incision and will leave the ...
... right up to the early 70s , , WEDNESDAY, Aug. 22 ... down their sex lives, a new study shows. , The ... problems of U.S. adults age 57 and older finds many ... sexual activity dropped only slightly between the late 50s up ...
... no coverage meant tumors were spotted later, study found , ... with no health insurance are more likely than those with ... cancer, a U.S. study finds. , Each year, about 10,000 ... laryngeal cancer. The stage of cancer at the time of ...
... of its kind, researchers have discovered that in autistic ... single regions, and not just between regions, as was ... assistant professor of neurology at Wake Forest University School ... lead to earlier diagnosis and more targeted medications for ...
Cached Medicine News:Health News:Bipolar disorder relapses halved by Melbourne researchers 2Health News:Expenses Overshadow Optimism for Kidney Failure Patients 2Health News:Single-incision belly-button surgery to remove kidney performed first at UT Southwestern 2Health News:Many Older Americans Have Active Sex Lives 2Health News:Many Older Americans Have Active Sex Lives 3Health News:Many Older Americans Have Active Sex Lives 4Health News:Insurance Impacts Laryngeal Cancer Detection 2Health News:Research may unlock mystery of autism's origin in the brain 2
(Date:7/11/2014)... , July 11, 2014  Kindred Hospital Houston ... announce the opening of its new outpatient wound ... services to people with chronic, hard to heal ... can lead to amputation, lower leg wounds related ... delayed closure, and traumatic injury wounds which are ...
(Date:7/11/2014)... ST. LOUIS , July 11, 2014 ... medical device company, announced today the positive, ... of its innovative SPiNPerc™ procedure. The SPiNPerc ... use of a percutaneous approach to biopsy ... possible.  Hospitals, patients and physicians experience positive ...
(Date:7/10/2014)... CLEVELAND , July 10, 2014  The U.S. ... a three-year grant to University Hospitals (UH) Case Medical ... a new national model aimed at improving care for ... Oncology Care," the project will test a unique model ... patients with late-stage disease, significant comorbidities, or demonstrated need ...
Breaking Medicine Technology:Kindred Hospital Houston Northwest, With Wound Care Specialists, Opens Outpatient Wound Healing And Hyperbaric Center 2Veran Medical Publishes Lung Cancer Patient Management Study 2University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 2University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 3University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 4
... N.J., Oct. 27 Savient Pharmaceuticals, Inc. (Nasdaq: ... results for the third quarter 2010 following the close of ... Paul Hamelin, President, and David Gionco, Group Vice President, Chief ... call beginning at 9:00 a.m. Eastern Time on Friday, November ...
... 27 Express Scripts, Inc. (Nasdaq: ESRX ) announced ... or $0.57 per diluted share.  Third quarter adjusted earnings per share, ... increase of 55% over 2009. Third Quarter ... Tables 2 and 3) Total adjusted claims of ...
Cached Medicine Technology:Savient Pharmaceuticals to Hold Third Quarter 2010 Financial Results Conference Call on Friday, November 5, 2010 2Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 2Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 3Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 4Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 5Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 6Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 7Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 8Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 9Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 10Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 11Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 12Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 13Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 14Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 15Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 16
... from DePuy offers a comprehensive combination of ... OSHA recommendations regarding occupational exposure to blood ... standard for comfort. , ,The Nighthawk, a ... from DePuy, is a personal protection system ...
... setup, try Cadwell paired disc electrodes. They ... custom-molded contacts are 10 mm (0.4 in) ... stainless steel with a locator pin on ... coded and available in twisted pairs. Shielded ...
... Headlight Video Camera System (NTSC)With Maxenon ... Provides surgeon's eye view of any ... tapes or digital files for later ... from 8" to 36". Automatic Iris ...
... Wrap-around, silver/silver chloride ring electrodes ... For use with minicrocodile clip ... 10 cm (4 in) long, ... Each 100-count package contains 50 ...
Medicine Products: