Navigation Links
UCSF team discovers new way to predict breast cancer survival and enhance effectiveness of treatment
Date:4/2/2011

that the immune system is closely linked to cancer because it naturally keeps cancer in check or at least it's supposed to. The body is filled with immune cells that seek out and destroy tumors, but those cells often prove ineffective at controlling cancer completely. Moreover, certain types of cancer can actually co-opt immune cells and use them to help tumors grow.

Normally the immune system protects the body by unleashing on tumors an immune cell called a killer T cell. This cell is effective, but dangerous. It can shrink tumors, but it also can damage healthy tissue. So the immune system uses another type of immune cell, called a macrophage, to control killer T cells, calling them where needed and shutting them down to keep them from damaging healthy tissue.

Coussens and her colleagues found that some cancers subvert this process by using macrophages to suppress the killer T cells and keep them away from tumors.

A RATIONALLY DESIGNED CLINICAL TRIAL

This effect of this subversion was apparent in tumor biopsies the team examined from 677 people with breast cancer. An immune profile based on the relative abundance of three immune cells in the tumors the killer T cell, the macrophage, and another immune cell known as a helper T cell accurately predicted overall survival from the disease, determined whether an individual's cancer was prone to metastasize, and predicted whether it would recur once treated. The tumors that tended to fare worse under the treatment had fewer killer T cells in them.

This basic observation is what led to the new treatment strategy, which the team tried first in mice. They used a drug to reprogram mouse tumors, changing their immune profiles and looking to see whether that made them more susceptible to chemotherapy. It did. When they next gave the mice chemotherapy, their tumors grew slower and the mice lived longer without metastasis.

But will this work in people? The history
'/>"/>

Contact: Jason Socrates Bardi
jason.bardi@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. OHSU Doernbecher discovers new approach to drug resistance in aggressive childhood cancer
2. MU chemist discovers shortcut for processing drugs
3. deCODE discovers genetic markers that improve the power of PSA testing for detecting prostate cancer
4. UT professor defines play, discovers even turtles need recess
5. Research discovers how the deaf have super vision
6. Colorado researcher discovers mechanism for changing adult cells into stem-like cells
7. Researcher at Childrens Hospital LA discovers way to overcome radiation resistance in leukemia
8. TGen-Mayo Clinic study discovers role of DNA methylation in multiple myeloma blood cancer
9. Virginia Tech professor discovers new TB pathogen
10. UCSF-led team discovers familial link in rare childhood leukemia
11. UR discovers new way to boost vaccines, seeks patent
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... Kansas City, MO (PRWEB) July 30, 2014 ... care practices have recently been awarded the Patient-Centered ... bestowed by the National Committee for Quality Assurance. ... has achieved NCQA Level I, Level 2, or ... doctors who participate in Patient-Centered Medical Home report ...
(Date:7/29/2014)... 2014 1Heart Caregiver Services’ advocacy ... focus on Brain Fitness Education brings great acceptance ... Fitness Program Director Tee Barr delivered an exceptional ... unit and the Assisted Living section of Aegis ... Director Christy Rozsa and Aegis Life Neighborhood Director ...
(Date:7/29/2014)... 2014 VogueQueen.com, a well-known online supplier, ... newest trends in garment fashion by providing graceful and ... selling an all-inclusive array of sexy dresses , ... a lot of customers take price into consideration. Worry ... makes the purchase more affordable for all clients. ...
(Date:7/29/2014)... 29, 2014 Daily Gossip indicates that ... all other disturbing symptoms that hemorrhoids commonly causes. The ... and natural medicine expert. , The author of ... the elimination of symptoms such as itching, burning, pain ... more about the H Miracle by visiting the official ...
(Date:7/29/2014)... (EA) a form of acupuncture where a ... acupuncture needles produces significant improvements in fatigue, ... weeks for early stage breast cancer patients experiencing ... inhibitors (AIs) to treat breast cancer. The results ... led by researchers at the Perelman School of ...
Breaking Medicine News(10 mins):Health News:Saint Luke’s Medical Group Awarded Patient-Centered Medical Home 2011 Level 3 Recognition 2Health News:1Heart Caregiver Services Conducts Brain Fitness Education and Brings Tee Barr to Aegis Ventura 2Health News:1Heart Caregiver Services Conducts Brain Fitness Education and Brings Tee Barr to Aegis Ventura 3Health News:1Heart Caregiver Services Conducts Brain Fitness Education and Brings Tee Barr to Aegis Ventura 4Health News:VogueQueen.com Now Provides Graceful And Sexy Lingerie Collection For August 2Health News:H Miracle Review Exposes Natural Method to Cure Hemorrhoids 2Health News:Acupuncture improves quality of life for breast cancer patients using aromatase inhibitors 2Health News:Acupuncture improves quality of life for breast cancer patients using aromatase inhibitors 3
... New research shows a link between use of two ... used either pesticide developed Parkinson,s disease approximately 2.5 times ... a collaborative effort conducted by researchers at the National ... of the National Institutes of Health, and the Parkinson,s ...
... Reinberg HealthDay Reporter , SUNDAY, Feb. 13 ... antioxidants called flavonoids, especially berries, may be protecting themselves ... In addition to berries, flavonoids are found in a ... fruits. These compounds have been touted as protective against ...
... 12 (HealthDay News) -- Winter couch potatoes who decide to ... injury if they don,t take the proper steps to safely ... an exercise program or new sport, you need to get ... fitness, advised Dr. Anders Cohen, chief of neurosurgery and spine ...
... HealthDay Reporter , FRIDAY, Feb. 11 (HealthDay ... regularly, their ability to think, to plan and even ... In addition, exercise was linked to increased activity in ... and self-control, according to brain imaging scans analyzed by ...
... 11 (HealthDay News) -- In addition to the ... one dermatologist cautions that players may be sharing ... "Outbreaks of ringworm, herpes and methicillin-resistant Staphylococcus aureus ... and professional level throughout the world," dermatologist Dr. ...
... the enzyme that gives fireflies their glow, enables researchers ... thereby track the progression of infectious diseases or cancerous ... shave their fur. Developed by researchers with the Lawrence ... California (UC) Berkeley, this new bioluminescent probe has already ...
Cached Medicine News:Health News:NIH study finds 2 pesticides associated with Parkinson's disease 2Health News:Berries May Offer Sweet Protection Against Parkinson's Disease 2Health News:Berries May Offer Sweet Protection Against Parkinson's Disease 3Health News:Get Into Shape Before Spring Activities, Doctor Advises 2Health News:Overweight Kids Who Exercise Improve Thinking, Math Skills: Study 2Health News:Overweight Kids Who Exercise Improve Thinking, Math Skills: Study 3Health News:Skin Infections Can Spread Easily Among Athletes 2Health News:Skin Infections Can Spread Easily Among Athletes 3Health News:Firefly glow: Berkeley Lab scientists develop a hydrogen peroxide probe based on firefly luciferin 2Health News:Firefly glow: Berkeley Lab scientists develop a hydrogen peroxide probe based on firefly luciferin 3
(Date:7/29/2014)... , July 29, 2014  Landauer, Inc. (NYSE: ... and environmental radiation measurement and monitoring, outsourced medical physics ... financial results for the fiscal third quarter 2014 after ... The Company will host a conference call ... a.m. Central Time (10 a.m. Eastern Time). Investors may ...
(Date:7/29/2014)... WASHINGTON , July 29, 2014 New ... in Medicare Part D by a projected $2.9 to ... by the actuarial firm Milliman released today by the ... Part D premiums could increase by as much as ... hepatitis C drugs, including Sovaldi and Olysio. ...
(Date:7/29/2014)... July 29, 2014 Numotion,s Board of Directors has ... will be the company,s new Chief Executive Officer. ... career at GE where he worked primarily for GE Healthcare ... to over $5 billion. His most recent position was as ... "I am thrilled to join Numotion," said Mike ...
Breaking Medicine Technology:Landauer, Inc. Sets Date and Time for Announcement of Fiscal Third Quarter 2014 Results 2New Milliman Study: Hepatitis C Drugs Could Increase Medicare Part D Spending by $2.9 to $5.8 Billion in 2015 2Numotion Names Mike Swinford CEO 2
... 3, 2011 Nonin Medical, Inc., the inventor of ... a leader in noninvasive physiological monitoring, announced the worldwide ... Pulse Oximeter for medical monitoring manufacturers. ... wired pulse oximeter will provide a new level of ...
... Optimer Pharmaceuticals, Inc. (NASDAQ: OPTR ) ... Senior Vice President of Research and Development, Cynthia Schwalm ... M.D., as Senior Vice President of Pharmacovigilance. These newly ... the Company prepares for the potential launch of its ...
Cached Medicine Technology:Nonin Medical Launches Low Power Xpod®, Model 3012LP, OEM Pulse Oximeter Globally 2Optimer Pharmaceuticals Expands Senior Management Team 2Optimer Pharmaceuticals Expands Senior Management Team 3Optimer Pharmaceuticals Expands Senior Management Team 4Optimer Pharmaceuticals Expands Senior Management Team 5
Molt periosteal elevator #9, 18.5 cm, 7-1/4"....
Periosteal elevator #9, 18 cm, 7"....
Full curve periosteal elevator - cervical - sharp, round tip, length 184 mm (7 1/4")....
... The Frontier Anterior Deformity System ... Kass, Moss Miami, and Isola ... thoracoscopic procedures to deliver unsurpassed versatility, ... the highest level of versatility for ...
Medicine Products: