Navigation Links
UCSF team discovers new way to predict breast cancer survival and enhance effectiveness of treatment
Date:4/2/2011

that the immune system is closely linked to cancer because it naturally keeps cancer in check or at least it's supposed to. The body is filled with immune cells that seek out and destroy tumors, but those cells often prove ineffective at controlling cancer completely. Moreover, certain types of cancer can actually co-opt immune cells and use them to help tumors grow.

Normally the immune system protects the body by unleashing on tumors an immune cell called a killer T cell. This cell is effective, but dangerous. It can shrink tumors, but it also can damage healthy tissue. So the immune system uses another type of immune cell, called a macrophage, to control killer T cells, calling them where needed and shutting them down to keep them from damaging healthy tissue.

Coussens and her colleagues found that some cancers subvert this process by using macrophages to suppress the killer T cells and keep them away from tumors.

A RATIONALLY DESIGNED CLINICAL TRIAL

This effect of this subversion was apparent in tumor biopsies the team examined from 677 people with breast cancer. An immune profile based on the relative abundance of three immune cells in the tumors the killer T cell, the macrophage, and another immune cell known as a helper T cell accurately predicted overall survival from the disease, determined whether an individual's cancer was prone to metastasize, and predicted whether it would recur once treated. The tumors that tended to fare worse under the treatment had fewer killer T cells in them.

This basic observation is what led to the new treatment strategy, which the team tried first in mice. They used a drug to reprogram mouse tumors, changing their immune profiles and looking to see whether that made them more susceptible to chemotherapy. It did. When they next gave the mice chemotherapy, their tumors grew slower and the mice lived longer without metastasis.

But will this work in people? The history
'/>"/>

Contact: Jason Socrates Bardi
jason.bardi@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. OHSU Doernbecher discovers new approach to drug resistance in aggressive childhood cancer
2. MU chemist discovers shortcut for processing drugs
3. deCODE discovers genetic markers that improve the power of PSA testing for detecting prostate cancer
4. UT professor defines play, discovers even turtles need recess
5. Research discovers how the deaf have super vision
6. Colorado researcher discovers mechanism for changing adult cells into stem-like cells
7. Researcher at Childrens Hospital LA discovers way to overcome radiation resistance in leukemia
8. TGen-Mayo Clinic study discovers role of DNA methylation in multiple myeloma blood cancer
9. Virginia Tech professor discovers new TB pathogen
10. UCSF-led team discovers familial link in rare childhood leukemia
11. UR discovers new way to boost vaccines, seeks patent
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... 23, 2014 Celebrating a decade of ... today announced the awarding of $1,070,000 in grants to ... in recognition of the Foundation’s 1,000th grant. , “The ... our tradition of supporting community-based organizations that are working ... life in the Garden State,” said Robert A. Marino, ...
(Date:7/23/2014)... a growing body of research suggesting a safe ... treating postmenopausal breast cancer, with fewer detrimental side ... anti-hormone therapies. The study will be published in ... Reproductive Biology and Endocrinology . , Breast cancer ... in the United States. Approximately 70% of breast ...
(Date:7/23/2014)... 23, 2014 Global Cardio Care, Inc., ... External Counterpulsation (EECP), is celebrating the 100th birthday ... at the health center. , Weber has been ... receiving ongoing EECP therapy since 1999, he no longer ... CEO of Global Cardio Care, introduced the Sara ...
(Date:7/23/2014)... The voice on the recording was low and ... news he was infected with the human immunodeficiency virus (HIV) that ... next thing you know I was on the floor flat on ... was hopeful when the recording ended less than 10 minutes later. ... . because it is just God setting you up for ...
(Date:7/23/2014)... WEDNESDAY, July 23, 2014 (HealthDay News) -- For patients ... antiretroviral therapy may help control both viruses, a small ... findings to improve treatment strategies for people with the ... suppression with antiretroviral medications plays an important role in ... infection," said study leader Dr. Kenneth Sherman, a professor ...
Breaking Medicine News(10 mins):Health News:The Horizon Foundation for New Jersey Awards More than $1 million in Grants to 20 Non-profit Organizations 2Health News:The Horizon Foundation for New Jersey Awards More than $1 million in Grants to 20 Non-profit Organizations 3Health News:The Horizon Foundation for New Jersey Awards More than $1 million in Grants to 20 Non-profit Organizations 4Health News:The Horizon Foundation for New Jersey Awards More than $1 million in Grants to 20 Non-profit Organizations 5Health News:Hormones after breast cancer: Not fuel for the fire after all? 2Health News:Hormones after breast cancer: Not fuel for the fire after all? 3Health News:Hormones after breast cancer: Not fuel for the fire after all? 4Health News:Hormones after breast cancer: Not fuel for the fire after all? 5Health News:Global Cardio Care Celebrates EECP Patient’s 100th Birthday 2Health News:HIV clinic-based audio project emphasizes the power of patient voices 2Health News:HIV clinic-based audio project emphasizes the power of patient voices 3Health News:HIV Meds May Also Help Control Hepatitis C, Study Finds 2
... , , , , ANAHEIM, Calif., June ... entertainment, public health and justice professionals, and Drug Court graduates gathered ... and call for a Drug Court to be put within reach ... Court Professionals (NADCP) 15th Annual Training Conference. , , ...
... common cancers in China. Although the association between the ... the relation between smoking, alcohol drinking, family history of ... still remains uncertain. So it is important to investigate ... sporadic colorectal cancer. A research team led by ...
... Health Insurer Hires 200th Employee , , Momentum Builds ... Health Care Insurance Crisis , , AVENTURA, Fla., June ... health insurance benefit programs for the consumer market, today announced ... "Cinergy Health is a company with a clear mission -- ...
... ... & Public Relations® (BSAPR) a full-service, integrated strategic marketing services firm, today announced ... ... 2009 -- Blanchard Schaefer Advertising & Public Relations ® (BSAPR) a full-service, ...
... Thursday 11 June 2009: Undertaking a supervised exercise ... and physical function, reduce the need for daily ... depression and anxiety in people with rheumatoid arthritis ... at EULAR 2009, the Annual Congress of the ...
... STARTLING TRUTHS , , PALM COAST, Fla., June 11 ... photos are uploaded daily through digital networks such as Facebook and ... like acne have on the life of teens? Based on first ... social traits than if they had clear skin, according to results ...
Cached Medicine News:Health News:U.S. Drug Czar Addresses 2,500 Drug Court Professionals, Voices Strong Support for Expanding Drug Courts Throughout the Nation 2Health News:U.S. Drug Czar Addresses 2,500 Drug Court Professionals, Voices Strong Support for Expanding Drug Courts Throughout the Nation 3Health News:Cinergy Health Expands Staff in Face of Dramatic Growth 2Health News:Blanchard Schaefer Advertising & Public Relations Wins Healthcare Advertising Awards 2Health News:Blanchard Schaefer Advertising & Public Relations Wins Healthcare Advertising Awards 3Health News:Exercise improves functional and psycological ability and reduces steroid need in rheumatoid arthritis 2Health News:Photos: New Image Survey Reveals 'Perception Is Reality' When It Comes to Teenagers With Acne 2Health News:Photos: New Image Survey Reveals 'Perception Is Reality' When It Comes to Teenagers With Acne 3Health News:Photos: New Image Survey Reveals 'Perception Is Reality' When It Comes to Teenagers With Acne 4Health News:Photos: New Image Survey Reveals 'Perception Is Reality' When It Comes to Teenagers With Acne 5
(Date:7/23/2014)...  Varian Medical Systems (NYSE: VAR ) ... share in the third quarter of fiscal year 2014.  ... diluted share due to an approximately $8 million impairment ... investment in Augmenix, a privately-held company developing minimally invasive ... for the third quarter of fiscal year 2014, up ...
(Date:7/23/2014)... , July 23, 2014 UBM Medica ... – a new online community and information resource for ... manage and treat their patients with neurological disorders ... with an aging population, necessitates greater access to dedicated ...  Key statistics on neurological conditions include: , ...
(Date:7/23/2014)... , July 23, 2014 The Board of ... a leading provider of clinical trial imaging solutions, announced ... been named president and chief executive officer, effective immediately.  ... August 2013 and has held the positions of interim ... Dr. Charles E. Phelps , Ph.D., ...
Breaking Medicine Technology:Varian Medical Systems Reports Results for Third Quarter of Fiscal Year 2014 2Varian Medical Systems Reports Results for Third Quarter of Fiscal Year 2014 3Varian Medical Systems Reports Results for Third Quarter of Fiscal Year 2014 4Varian Medical Systems Reports Results for Third Quarter of Fiscal Year 2014 5Varian Medical Systems Reports Results for Third Quarter of Fiscal Year 2014 6Varian Medical Systems Reports Results for Third Quarter of Fiscal Year 2014 7Varian Medical Systems Reports Results for Third Quarter of Fiscal Year 2014 8Varian Medical Systems Reports Results for Third Quarter of Fiscal Year 2014 9Varian Medical Systems Reports Results for Third Quarter of Fiscal Year 2014 10UBM Medica US Launches NeurologyTimes.com 2UBM Medica US Launches NeurologyTimes.com 3Eric T. Converse Named President And Chief Executive Officer Of VirtualScopics, Inc. 2Eric T. Converse Named President And Chief Executive Officer Of VirtualScopics, Inc. 3Eric T. Converse Named President And Chief Executive Officer Of VirtualScopics, Inc. 4
... International, Inc., (OTC Bulletin Board: OXIS ; ... conference call with investors on Tuesday, March 22, 2011 ... During the call Anthony Cataldo, Chief Executive Officer, and ... the Company,s growth strategy, and take questions from call ...
... LA JOLLA, Calif., March 9, 2011 Scientific ... the foundation for the new drug Benlysta® (belimumab), approved today ... the most common type of lupus, is the first in ... attacking its own critical tissues. "I am deeply ...
Cached Medicine Technology:New Lupus Drug Results From Scripps Research Technology 2New Lupus Drug Results From Scripps Research Technology 3New Lupus Drug Results From Scripps Research Technology 4
Fully lined with cotton material for extra softness against patients skin. The 3 double adjustable soft Velcro® bands provide vertical/downward pressure for adjustable comfort following submuscu...
This compression garment can be used for Breast Augmentation, Augmentation Mammaplasty, Trans Umbilical Breast Augmentation, Transaxillary Submuscular Augmentation....
Sub Pectoral Breast Augmentation Wrap...
Bandeau Bra...
Medicine Products: