Navigation Links
UCSF team discovers new way to predict breast cancer survival and enhance effectiveness of treatment
Date:4/2/2011

that the immune system is closely linked to cancer because it naturally keeps cancer in check or at least it's supposed to. The body is filled with immune cells that seek out and destroy tumors, but those cells often prove ineffective at controlling cancer completely. Moreover, certain types of cancer can actually co-opt immune cells and use them to help tumors grow.

Normally the immune system protects the body by unleashing on tumors an immune cell called a killer T cell. This cell is effective, but dangerous. It can shrink tumors, but it also can damage healthy tissue. So the immune system uses another type of immune cell, called a macrophage, to control killer T cells, calling them where needed and shutting them down to keep them from damaging healthy tissue.

Coussens and her colleagues found that some cancers subvert this process by using macrophages to suppress the killer T cells and keep them away from tumors.

A RATIONALLY DESIGNED CLINICAL TRIAL

This effect of this subversion was apparent in tumor biopsies the team examined from 677 people with breast cancer. An immune profile based on the relative abundance of three immune cells in the tumors the killer T cell, the macrophage, and another immune cell known as a helper T cell accurately predicted overall survival from the disease, determined whether an individual's cancer was prone to metastasize, and predicted whether it would recur once treated. The tumors that tended to fare worse under the treatment had fewer killer T cells in them.

This basic observation is what led to the new treatment strategy, which the team tried first in mice. They used a drug to reprogram mouse tumors, changing their immune profiles and looking to see whether that made them more susceptible to chemotherapy. It did. When they next gave the mice chemotherapy, their tumors grew slower and the mice lived longer without metastasis.

But will this work in people? The history
'/>"/>

Contact: Jason Socrates Bardi
jason.bardi@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. OHSU Doernbecher discovers new approach to drug resistance in aggressive childhood cancer
2. MU chemist discovers shortcut for processing drugs
3. deCODE discovers genetic markers that improve the power of PSA testing for detecting prostate cancer
4. UT professor defines play, discovers even turtles need recess
5. Research discovers how the deaf have super vision
6. Colorado researcher discovers mechanism for changing adult cells into stem-like cells
7. Researcher at Childrens Hospital LA discovers way to overcome radiation resistance in leukemia
8. TGen-Mayo Clinic study discovers role of DNA methylation in multiple myeloma blood cancer
9. Virginia Tech professor discovers new TB pathogen
10. UCSF-led team discovers familial link in rare childhood leukemia
11. UR discovers new way to boost vaccines, seeks patent
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2015)... (PRWEB) March 27, 2015 Florida Hospital is ... as the team’s exclusive health care provider for the 2015 ... Florida Hospital provides medical care and an athletic trainer for ... will kick off its season against the Cleveland Gladiators at ... “This partnership is extremely important to us as it gives ...
(Date:3/27/2015)... (PRWEB) March 27, 2015 The federal ... that allege the statin medication increases the risk that ... Pfizer Inc.’s Motion to Dismiss four individual cases that ... Case Management Order issued in the U.S. District Court, ... determined that the dismissals were warranted because the plaintiffs ...
(Date:3/27/2015)... Texas (PRWEB) March 27, 2015 First ... 7am today. The new facility is located 12665 W Lake ... “As a resident of Summerwood, I look forward to delivering ... said Dr. Sowell, Facility Medical Director of First Choice Emergency ... Choice Emergency Room made a donation to Summer Creek High ...
(Date:3/27/2015)... March 27, 2015 Bleeding is ... undergoing percutaneous coronary intervention (PCI), resulting in increased ... a “risk-treatment paradox,” in which the highest-risk PCI ... are treated less often with bleeding avoidance strategies ... Luke’s Mid America Heart Institute asked the question ...
(Date:3/27/2015)... Top medical tourism firm, VisitandCare.com ... the Dominican Republic to benefit from the experience of ... the medical tourism industry upside-down and becoming a choice ... services becoming the central influence. , “Trust is ... are not only attracted to low-cost surgical enhancement, but ...
Breaking Medicine News(10 mins):Health News:Florida Hospital Is Kicking off the 2015 Season as the Exclusive Health Care Provider for the Tampa Bay Storm 2Health News:Florida Hospital Is Kicking off the 2015 Season as the Exclusive Health Care Provider for the Tampa Bay Storm 3Health News:Lipitor Lawsuits Move Forward in Federal Multidistrict Litigation, as Court Rules on Pfizer’s Motion to Dismiss Certain Cases 2Health News:Lipitor Lawsuits Move Forward in Federal Multidistrict Litigation, as Court Rules on Pfizer’s Motion to Dismiss Certain Cases 3Health News:First Choice Emergency Room Opens New Facility in Houston, Texas 2Health News:Precision Medicine Improves Use of Bleeding Avoidance Strategies and Reduces Bleeding in Patients Undergoing Percutaneous Coronary Intervention 2Health News:Precision Medicine Improves Use of Bleeding Avoidance Strategies and Reduces Bleeding in Patients Undergoing Percutaneous Coronary Intervention 3Health News:Dominican Republic Plastic Surgery Provider Turning Medical Tourism Upside-Down 2Health News:Dominican Republic Plastic Surgery Provider Turning Medical Tourism Upside-Down 3
... yourself from the dangers of frostbiteROSEMONT, Ill., Jan. 13 /PRNewswire-USNewswire/ ... country this week, but cold weather is no excuse to ... go outside for some fresh air and exercise , ... body tissues are frostbitten, skin cells become damaged -- sometimes ...
... the Divided We Fail pledgeNEW YORK, Jan. 13 Today ... to thousands of AARP members pledging to work with President ... health care crisis and economic downturn. Senator Schumer spoke ... this afternoon from his office in Washington, DC. "Since ...
... Says Investment in Medicaid Should be Key Health Policy ... Speaker of the Texas House in Austin and a ... has created new and exciting opportunities in regard to ... of the state,s oldest, most vulnerable seniors, the Texas ...
... 13 Courage Center,s Ski and Snowboard,Program (CCSS) seeks volunteers ... Minn. , Volunteers assist skiers with ... 25-March 8, from 1 to 4 p.m. (no session,over President,s ... Volunteer instructors are also being recruited and ...
... pharmacy error in child,s medication; young man is hospitalized ... on labels causes grandmother to confuse medicationsWASHINGTON, Jan. 13 ... a dose of medication if you were not fully ... you do if you couldn,t read important drug information ...
... health issues, comply with federal and state health ... to help Philadelphia students eat healthier, get more ... conscious, the school district of Philadelphia announced it ... web-based program. The program is being provided to ...
Cached Medicine News:Health News:Is Jack Frost Nipping At Your Nose? 2Health News:Is Jack Frost Nipping At Your Nose? 3Health News:Senator Schumer Speaks to 4,900 AARP Members Pledging Bipartisan Action on Nation's Health and Economic Crises 2Health News:Senator Schumer Speaks to 4,900 AARP Members Pledging Bipartisan Action on Nation's Health and Economic Crises 3Health News:THCA: Protecting Seniors, Respecting Taxpayers the Right Agenda for Texas 2Health News:THCA: Protecting Seniors, Respecting Taxpayers the Right Agenda for Texas 3Health News:AFB Survey Finds Drug Labeling Puts People with Vision Loss at Serious Medical Risk 2Health News:AFB Survey Finds Drug Labeling Puts People with Vision Loss at Serious Medical Risk 3Health News:AFB Survey Finds Drug Labeling Puts People with Vision Loss at Serious Medical Risk 4Health News:Philadelphia School District and Independence Blue Cross Partner to Improve Student Wellness and Reduce Childhood Obesity 2Health News:Philadelphia School District and Independence Blue Cross Partner to Improve Student Wellness and Reduce Childhood Obesity 3Health News:Philadelphia School District and Independence Blue Cross Partner to Improve Student Wellness and Reduce Childhood Obesity 4Health News:Philadelphia School District and Independence Blue Cross Partner to Improve Student Wellness and Reduce Childhood Obesity 5
(Date:3/27/2015)... March 27, 2015 BioCorRx, Inc. ( ... Ana, California is a healthcare solutions organization, which ... estimated at $22 billion in the U.S. alone. The Company ... FDA-approved Naltrexone in a specially compounded form for outpatient surgical ... and New Zealand ) to ...
(Date:3/27/2015)... 2015 Across the global healthcare landscape, the ... clinical development, market education, and regulatory compliance. As emerging ... function is expected to increase in prominence and follow ... According to research by benchmarking firm, Best Practices, LLC, ... to Medical Affairs. Among companies in India ...
(Date:3/27/2015)...  The quality function within the medical device sector ... standards at every stage of the product life cycle. ... have the challenge of balancing quality and safety with ... effectively balance these priorities risk funding and staffing for ... regulatory scrutiny. For the third consecutive year, ...
Breaking Medicine Technology:Small Cap IR Correction -- BioCorRx Inc. Positions Itself Through Strategic Partnerships To Gain Market Share Of The $22 Billion Substance Abuse Treatment Market In The U.S. 2Medical Affairs Capabilities Expanding in Emerging Marketplaces 2New Medical Device Quality Study Finds Regulatory Environment is Boosting Quality Spending, Especially for Large Companies 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: