Navigation Links
UCSF team discovers key to fighting drug-resistant leukemia
Date:5/18/2011

Doctors who treat children with the most common form of childhood cancer acute lymphoblastic leukemia are often baffled at how sometimes the cancer cells survive their best efforts and the most powerful modern cancer drugs.

Now a team of scientists led by researchers at the University of California, San Francisco have uncovered the basis for this drug resistance: BCL6, a protein that leukemia cells use to stay alive. Targeting this protein may be the key to fighting drug-resistant leukemia, a discovery that may make cancer drugs more powerful and help doctors formulate powerful drug cocktails to cure more children of leukemia.

"We believe this discovery is of immediate relevance to patient care," said Markus Mschen, MD, PhD, a professor of laboratory medicine at UCSF and the senior author on the study.

As described in the journal Nature this week, Mschen and his colleagues showed that mice with drug-resistant leukemia can be cured of the disease when given conventional cancer drugs in combination with a compound that disables the BCL6 protein. This compound was initially developed by Ari Melnick, a professor of pharmacology at the Weill Cornell College of Medicine in New York and a co-author of the study.

A COMMON FORM OF CANCER IN CHILDREN

Acute lymphoblastic leukemia is the most common form of cancer in children and accounts for about 23 percent of all cases of cancer in children under the age of 15, according to the National Cancer Institute.

In this form of cancer, leukemia cells in the bloodstream and bone marrow continuously multiply, crowding out other, healthy cells. The disease progresses rapidly, and the leukemia cells begin to infiltrate tissues in other parts of the body. Treatment is neither cheap nor easy but it can be miraculous. It usually involves a long course of drugs that can be physically and emotionally taxing for the children and their parents. Once finished, many
'/>"/>

Contact: Jason Socrates Bardi
jason.bardi@ucsf.edu
415-502-4608
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. UCSF team discovers new way to predict breast cancer survival and enhance effectiveness of treatment
2. OHSU Doernbecher discovers new approach to drug resistance in aggressive childhood cancer
3. MU chemist discovers shortcut for processing drugs
4. deCODE discovers genetic markers that improve the power of PSA testing for detecting prostate cancer
5. UT professor defines play, discovers even turtles need recess
6. Research discovers how the deaf have super vision
7. Colorado researcher discovers mechanism for changing adult cells into stem-like cells
8. Researcher at Childrens Hospital LA discovers way to overcome radiation resistance in leukemia
9. TGen-Mayo Clinic study discovers role of DNA methylation in multiple myeloma blood cancer
10. Virginia Tech professor discovers new TB pathogen
11. UCSF-led team discovers familial link in rare childhood leukemia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... 30, 2014 Top10inaction, a professional product ... providers in the online service industry for the month ... leaders Webex, GotoMeeting and Infinite. , With over thousands ... to determine which provider is ideally a good fit ... search for compelling consumer goods and services agencies to ...
(Date:8/29/2014)... Pittsburgh, PA (PRWEB) August 29, 2014 ... inventor from Harrisburg, Pa., had to have breast reconstruction. ... to be sub-par, so she decided that there needed ... a better look for a woman or man who ... visible, as well as promotes confidence and peace of ...
(Date:8/29/2014)... The West African Ebola outbreak took a more deadly turn ... new cases this week -- the biggest jump in infections ... Liberia, the U.N. health agency said, but cases in Guinea ... reported. "There are serious problems with case management ... "The situation is worsening in Liberia and Sierra Leone." ...
(Date:8/29/2014)... ReputationChief.Com, a well-established online reputation management firm, has ... service has been launched to help individuals and organizations ... them. , In order to make sure that the ... to its clients, ReputationChief.Com has designed the service after ... , As per the indications from the company management, ...
(Date:8/29/2014)... Los Angeles, CA (PRWEB) August 29, 2014 ... Sands DDS, is now offering mini implants to area ... replaced permanently without worries of long-term teeth shifting and ... dependability associated with full-size dental implants , their ... well as faster placement and easier recovery. Once placed, ...
Breaking Medicine News(10 mins):Health News:Top10InAction Reveals Best Web Conference Providers 2Health News:Biggest Ever Weekly Rise in Ebola Cases, U.N. Agency Says 2Health News:Biggest Ever Weekly Rise in Ebola Cases, U.N. Agency Says 3Health News:ReputationChief.Com Announces a New Service ‘Remove Bad Reviews’ 2Health News:Dental Implants Dentist, Kevin Sands DDS, Is Now Offering Mini Implants 2
... allows physicians and dentists to request disability insurance quotes, compare ... ... San Clemente, CA (PRWEB) July 31, 2008 ... disability insurance] and life insurance brokerage service, recently launched a ...
... the launch of its kidney disease education and screening program in New ... ... American Kidney Fund today announced the launch of its www.kidneyfund.org ... , , ,The American Kidney Fund,s MIKE program (Minority Intervention and Kidney ...
... containing SSRIs can interrupt dopamine levels and other hormonal levels causing ... ... (PRWEB) July 31, 2008 -- Recent trends of antidepressants being prescribed ... time high. In fact, according to a government study, antidepressants have ...
... blood drive at its Phillipsburg location on Saturday, August 9th from ... ... 31, 2008 -- Phillipsburg Easton Honda is hosting a blood drive ... 1:45PM., , , , ,"Demand for blood donations remains high, and ...
... skin tissues gives a new cellulite solution the edge to help the skin ... ... troubled and photo-damaged skin can be a frustrating part of your life. There ... scaly rashes and age spots. , , ,These ailments can be hard to ...
... Georges C. Benjamin, MD, FACP, FACEP (E), ... WASHINGTON, July 30 The American Public,Health Association ... the Family Smoking and Tobacco Control Act with ... the health of,Americans, particularly children, by giving the ...
Cached Medicine News:Health News:New Website Helps Doctors and Dentists Locate Disability Insurance 2Health News:New Website Helps Doctors and Dentists Locate Disability Insurance 3Health News:American Kidney Fund Launches Screening Program in New York City 2Health News:Lyriana Announces Antidepressants Now Linked to Declining Libido in Women 2Health News:Lyriana Announces Antidepressants Now Linked to Declining Libido in Women 3Health News:Lyriana Announces Antidepressants Now Linked to Declining Libido in Women 4Health News:Phillipsburg Easton Honda to Host Miller-Keystone Blood Drive 2Health News:Phillipsburg Easton Honda to Host Miller-Keystone Blood Drive 3Health News:New Skin Revitalizing Product Uses Naturally Occurring Serum for the Repair of Sun Damaged Skin 2Health News:New Skin Revitalizing Product Uses Naturally Occurring Serum for the Repair of Sun Damaged Skin 3
(Date:8/28/2014)... NEW YORK, Aug. 28, 2014 Reportlinker.com ... available in its catalogue: North America ... 2020 http://www.reportlinker.com/p02343466/North-America-Aesthetic-Lasers-and-Energy-Devices-Market-Outlook-to-2020.html ... Market Outlook to 2020 Summary GlobalData,s ... Devices Market Outlook to 2020", provides key market ...
(Date:8/28/2014)... YORK , Aug. 28, 2014 ... new market research report is available ... Laboratories, Safety and Compliance Services Industry ... and Revenue Forecasts to 2021, NAIC ... .html Testing Laboratories, ...
(Date:8/28/2014)... NEW YORK , Aug. 28, 2014 /PRNewswire/ ... report is available in its catalogue: ... to 2020 http://www.reportlinker.com/p02343442/Germany-Aesthetic-Lasers-and-Energy-Devices-Market-Outlook-to-2020.html ... Market Outlook to 2020 Summary GlobalData,s ... Market Outlook to 2020", provides key market data ...
Breaking Medicine Technology:North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 2North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 3North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 4North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 5North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 6North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 7North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 8North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 9North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 10North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 11North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 12North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 13North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 14North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 15North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 16Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 2Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 3Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 4Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 5Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 6Germany Aesthetic Lasers and Energy Devices Market Outlook to 2020 2Germany Aesthetic Lasers and Energy Devices Market Outlook to 2020 3Germany Aesthetic Lasers and Energy Devices Market Outlook to 2020 4Germany Aesthetic Lasers and Energy Devices Market Outlook to 2020 5Germany Aesthetic Lasers and Energy Devices Market Outlook to 2020 6Germany Aesthetic Lasers and Energy Devices Market Outlook to 2020 7Germany Aesthetic Lasers and Energy Devices Market Outlook to 2020 8Germany Aesthetic Lasers and Energy Devices Market Outlook to 2020 9
Fructosamine controls level 3...
Drug controls sera available in three levels for the control of accuracy and percision for up to 18 analytes...
Human based material available in two levels for thecontrol of percision for up to 10 analytes...
Human based assayed sera available in three levels for the control of accuracy and precision for up to 25 analytes...
Medicine Products: