Navigation Links
UCSF team closer to creating safe embryonic-like stem cells
Date:4/12/2009

A team of UCSF researchers has for the first time used tiny molecules called microRNAs to help turn adult mouse cells back to their embryonic state. These reprogrammed cells are pluripotent, meaning that, like embryonic stem cells, they have the capacity to become any cell type in the body.

The findings suggest that scientists will soon be able to replace retroviruses and even genes currently used in laboratory experiments to induce pluripotency in adult cells. This would make potential stem cell-based therapies safer by eliminating the risks posed to humans by these DNA-based methods, including alteration of the genome and risk of cancer.

"Using small molecules such as microRNAs to manipulate cells will play a major role in the future of stem cell biology," says senior author Robert Blelloch, MD, PhD, of the Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research at UCSF.

Scientists are interested in reprogramming because it would offer a way to create cells that provide a genetic match for individual patients. A patient's skin cells could be reverted to pluripotent cells in the culture dish and then prompted to differentiate into adult cells, such as those of the heart, lung and brain. These cells could then be transplanted into patients, without the fear of rejection.

The study, reported in the April 12, 2009 advanced online edition of the journal "Nature Biotechnology" and scheduled for the May 8, 2009 print issue, used a combination of microRNAs and retrovirus-introduced genes to transform fibroblast cells -- found throughout the body of mice and humans -- into pluripotent cells.

The current finding comes on the heels of a study published by the group in the December 2008 print edition of "Nature Genetics" that showed that microRNAs, which can be synthesized in the lab, encouraged embryonic stem cells to self-replicate, a finding that has implications for replicating stem cells in
'/>"/>

Contact: Jennifer OBrien
jobrien@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Yale Plans Closer Look at Exercise and Cancer
2. University of Washington scientists one step closer to stopping bone loss during spaceflight
3. Scientists closer to understanding how to control high blood sugar
4. Muscular dystrophy mystery solved; Mizzou scientist moves closer to MD solution
5. Video: Pampers Together with Actress Salma Hayek Helps UNICEF Move Closer Toward Goal of Eliminating Deadly Tetanus Through Global One Pack = One Vaccine Campaign
6. Pelosi: SCHIP Vote Brings Us One Step Closer to Providing Health Care for 11 Million Children
7. Health Plans, Employers Take Closer Look at Costs and Expand Disease Management Initiatives in Response to Diabetes Prevalence Increase
8. Molecular therapy for spinal muscular atrophy closer to clinical use
9. Decongestant Exposure Needs Closer Look
10. FDA Takes Closer Look at Wrinkle Treatments
11. Stem cell therapies for heart disease -- 1 step closer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/26/2014)... News) -- Parents need to take an active role ... warns. Parents must make sure sports-playing teens have ... Dodick, chair of the American Migraine Foundation and a ... Medicine in Scottsdale, Ariz. in an American Migraine Foundation, ... coach involved with teens sports needs to have appropriate ...
(Date:11/24/2014)... From embedded sensors and biometrics to elite training ... take center stage at the FitnessTech Summit , presented ... 2015 International CES® , January 6, 2015 in Las Vegas ... The bond between fitness and technology is stronger than ever ... more about the human body. , “Fitness technology has become ...
(Date:11/24/2014)... 2014 Global electrophysiology devices market ... 2020, according to a new study by Grand ... arrhythmias clubbed with growing global geriatric population base ... still in the budding stage, the electrophysiology devices ... rates in the recent times, with physicians increasingly ...
(Date:11/24/2014)... (PRWEB) November 24, 2014 Volpara ... version 1.2 at the 100th Annual Meeting of ... 30-December 5, 2014 (RSNA Booth 1752 – South ... of VolparaAnalytics and the rest of its innovative ... and VolparaDoseRT, which enable personalized measurements of volumetric ...
(Date:11/24/2014)... November 24, 2014 Residents of retirement ... in this year’s SENIORS GOT TALENT, an annual online ... From piano players to classic crooners, to seniors partying ... older adults are indeed living young. , “SENIORS GOT ... there’s a cash prize, has always been about highlighting ...
Breaking Medicine News(10 mins):Health News:Parents Need to Take Lead on Teen Concussion Prevention 2Health News:Next Wave Fitness Products Debut at FitnessTech Summit Living in Digital Times at the 2015 International CES 2Health News:Next Wave Fitness Products Debut at FitnessTech Summit Living in Digital Times at the 2015 International CES 3Health News:Next Wave Fitness Products Debut at FitnessTech Summit Living in Digital Times at the 2015 International CES 4Health News:Electrophysiology Devices Market Worth Forecasted To Reach $6.19 Billion By 2020: Grand View Research, Inc. 2Health News:Electrophysiology Devices Market Worth Forecasted To Reach $6.19 Billion By 2020: Grand View Research, Inc. 3Health News:Electrophysiology Devices Market Worth Forecasted To Reach $6.19 Billion By 2020: Grand View Research, Inc. 4Health News:Volpara Solutions to Launch VolparaAnalytics 1.2 at RSNA 2Health News:Volpara Solutions to Launch VolparaAnalytics 1.2 at RSNA 3Health News:Nursing Homes & Assisted Living Retirement Communities Enter Seniors Guide's Seniors Got Talent 2Health News:Nursing Homes & Assisted Living Retirement Communities Enter Seniors Guide's Seniors Got Talent 3
... ... Health , ... (PRWEB) October 11, 2009 – The YWCA’s Week Without Violence kicks off today, acting as ... need for trained social workers throughout the world. Those interested becoming community support workers can ...
... - Mentalympians(TM) announced today, on this World Mental Health ... based in Australia, Canada, New Zealand, Scotland and the ... found on www.mentalympians.org . , Mentalympians has been ... operated through a network of mental health consumer groups. ...
... ... MAN (renewman.com), the first male hormone treatment program in the U.S., continues to ... symptoms, including andropause. A common condition among men ages 35 and older, reNEW ... doctor that can test, diagnose and treat hormone deficiencies through safe, self-administered treatments. ...
... with mental, neurological, and substance use (MNS) disorders in low ... the mental health "treatment gap." This week PLoS ... helping to close the gap. The series coincides with ... Mental Health, a collaborative initiative of the London School of ...
... InfoLogix, Inc. (Nasdaq: IFLG ), a leading ... and commercial industries, today announced that it has retained ... based in West Conshohocken, PA to assist InfoLogix in ... negotiates financing transactions at virtually every level of the ...
... (MIS), best known for regulating in utero sexual differentiation in ... according to a new study published online October 9 in ... associated with breast cancer risk, Joanne F. Dorgan, Ph.D., MPH, ... conducted a prospective case-control study of 309 participants who were ...
Cached Medicine News:Health News:YWCA's Week Without Violence Oct. 11-17 a Reminder That Community Support Workers Remain in High Demand 2Health News:World-first mental health media initiative announces inaugural Advisory Group 2Health News:Locate a Male Menopause Physician with reNEW MAN 2Health News:Locate a Male Menopause Physician with reNEW MAN 3Health News:Locate a Male Menopause Physician with reNEW MAN 4Health News:How should mental, neurological and substance use disorders be treated where resources are scarce? 2Health News:InfoLogix Announces News Related to its Recent Corporate Development Initiatives 2
(Date:11/24/2014)... 24, 2014  Surgical Theater, LLC, announced today that ... th opening of Europe,s ... "C. Besta." The SuRgical Planner (SRP) and the Surgical ... event for their 3D navigation and augmented reality capabilities ... , Professor and Chair, Department of Neurosurgery at Mount ...
(Date:11/24/2014)...  Surgical Theater LLC ha annunciato oggi ... l,apertura in data 24 novembre del primo ... IRCCS Istituto Neurologico Nazionale "C. Besta". I ... pianificazione chirurgica) e Surgical Navigation Advanced Platform ... presentati in occasione dell,evento dedicato alle loro ...
(Date:11/23/2014)... Calif. , Nov. 23, 2014 Anthera ... that Paul F. Truex , President and Chief ... 2014 Annual Piper Jaffray Healthcare Conference. ... , at the Palace Hotel in New ... Pharmaceuticals Anthera Pharmaceuticals is a biopharmaceutical company ...
Breaking Medicine Technology:Surgical Theater's Technology to be Showcased at the Opening of the Besta NeuroSim Center in Milan, Italy 2Surgical Theater's Technology to be Showcased at the Opening of the Besta NeuroSim Center in Milan, Italy 3La tecnologia di Surgical Theater in mostra in Italia all'apertura del centro Besta NeuroSim di Milano 2La tecnologia di Surgical Theater in mostra in Italia all'apertura del centro Besta NeuroSim di Milano 3La tecnologia di Surgical Theater in mostra in Italia all'apertura del centro Besta NeuroSim di Milano 4Anthera Pharmaceuticals to Present at Annual Piper Jaffray Healthcare Conference 2
... Colo., March 14, 2012  Hyde Engineering and Consulting, a ... manufacturing equipment and clean utility systems, announced today that ... States Sales Manager. Tom brings to Hyde ... customer service. He previously was Western Regional Sales Manager ...
... 13, 2012  Thomson Reuters announced new insights into global ... new reports tracking global innovation and brand protection trends ... Innovation: Twelve Key Technology Areas and Their States of ... Trademark Activity, Evolution and Important Changes, track patent ...
Cached Medicine Technology:Tom Weller Joins Hyde Engineering and Consulting 2Patent and Trademark Trends 2011: Thomson Reuters Evaluates the State of Global IP 2
9 mm diameter pigtail curved blunt probes. Stainless steel. Round knurled handle with polished finish. Includes pre-cut polyethylene tubes. Overall length: 5.9 inches....
The Ultima 2000 SE is flexible in meeting the needs of both office and operating room use. It is the answer for the clinical practice with a wide range of ophthalmic demands looking for minimal risk ...
The VISULAS 532s combines ease of use, efficiency and safety to provide ophthalmologists with an overall system sharply focused on their requirements. ,The VISULAS 532s is a laser of many talent...
Two point fixation, tips separated by 13 mm. Each tip has 0.12 mm, 1 x 2 teeth. Flat serrated handle with polished finish. Without lock....
Medicine Products: