Navigation Links
UCSF researchers identify promising new treatment for childhood leukemia
Date:3/30/2011

ransplantation because of advanced illness or the lack of a suitable donor, Braun said.

The researchers treated mice genetically engineered to have JMML with a drug that inhibits a signaling protein called MEK. The drug, known as a MEK inhibitor, blocks just one of the many chemical pathways controlled by Ras. Although several pharmaceutical companies already are developing these drugs, this is the first time a MEK inhibitor has been piloted as a treatment for JMML.

Remarkably, within one week of starting treatment, leukemia symptoms in nearly all of the afflicted mice reversed. Specifically, mice that were treated with the MEK inhibitor produced more red blood cells and fewer white blood cells than untreated mice, and the anemia commonly associated with JMML also disappeared.

According to the researchers, a particularly compelling aspect of the findings is that even after treatment, the majority of the animals' blood was still being produced by the mutant cells that previously caused the disease.

"The most striking aspect of our findings was that the treatment helped the mice not by making the cancer cells go away, but by forcing them to act like normal cells, despite their mutation," said first author Natalya Lyubynska, MD, an internal medicine resident at the University of Michigan. Lyubynska completed this research in Braun's lab as a UCSF medical student, with support from the UCSF Helene and Charles Linker Fellowship and was awarded the UCSF Dean's Prize for Outstanding Student Research for this work.

Through the positive effects of treatment, the study also helps clarify the mechanism by which the Ras signaling pathway regulates cell growth and confirms that the MEK protein plays a key role in the development of JMML.

"It appears that Ras causes disease in part by producing an imbalance of the kinds of cells made in the bone marrow, and that inhibiting MEK can reverse that process," Braun said. "We hop
'/>"/>

Contact: Kate Vidinsky
kate.vidinsky@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/18/2013)... Each year, the American Gastroenterological Association (AGA) recognizes ... in gastroenterology through its esteemed recognition awards. , ... individuals who work tirelessly to advance the science ... to announce the 2013 recognition award honorees who ... tremendous contributions to our field," said Loren Laine, ...
(Date:5/18/2013)... California (PRWEB) May 18, 2013 Online watch ... be Rolex watch owners at a fraction of ... of luxury timepieces in the world, buyers are urged to ... compared to buying a Rolex watch from a brick-and-mortar store, ... owned Rolex watches priced at unbelievable rates. Although some ...
(Date:5/18/2013)... who swallow high-powered magnets often need surgery and other ... new study. The researchers, from the Louisiana State ... than 79 percent of children who swallowed very strong ... in which a tube containing a camera is inserted ... cases can be treated through observation or by pumping ...
(Date:5/18/2013)... The use of a smartphone application significantly improves ... research presented today at Digestive Disease Week (DDW). ... of the procedure, includes dietary restrictions and requires ... strict intervals. The better the preparation, the easier ... precancerous polyps in the colon. The study, which ...
(Date:5/18/2013)... May 18, 2013 In a May ... Preventive Double Mastectomy After Discovering Cancer Gene,” Fox News ... procedure upon learning that she carried a gene that ... breast cancer and a 50 percent risk of ovarian ... up on May 16, 2013 with a blog post ...
Breaking Medicine News(10 mins):Health News:AGA honors distinguished clinicians, researchers and educators with prestigious recognition awards 2Health News:AGA honors distinguished clinicians, researchers and educators with prestigious recognition awards 3Health News:AGA honors distinguished clinicians, researchers and educators with prestigious recognition awards 4Health News:AGA honors distinguished clinicians, researchers and educators with prestigious recognition awards 5Health News:Time and Gems Offers Buyers the Largest Collection of Rolex Watches Yet 2Health News:Time and Gems Offers Buyers the Largest Collection of Rolex Watches Yet 3Health News:Swallowing Magnets Can Be Fatal for Children 2Health News:New smartphone application improves colonoscopy preparation 2Health News:Angelina Jolie – Scarless Breast Augmentation Surgery 2
... ayurveda practitioners should get licences to practice this ancient ... ,Lakshmi C. Mishra, director of the Ayurvedic Health ... Board of Physicians to introduce an official licensing programme, ... ,The ayurveda system of medicine is based on the ...
... face a risk of dementia, which is a disorder of ... changes. ,Every year, about 23,000 US women are ... disease. To reduce the risk of this disease surgeons often ... Walter Rocca at Mayo Clinic studied 2,511 women who had ...
... list is growing day by day, the New South Wales (NSW) ... queue//. ,It has decided to allocate to more money ... help cut elective surgery waiting lists. ,The Hunter New ... boost of $500,000 each. ,This would help them to ...
... The HIV Sentinel Surveillance data for 2005 shows the prevalence ... in the state.// According to the latest study that was ... that the prevalence among antenatal women has fallen to 0.5 ... comprising 24 district headquarters hospitals, 29 first referral units, 5 ...
... The Union Finance Minister P. Chidambaram said that the inflation rate ... remain under control.// ,He said that various steps are ... happy it is below four percent now. Anything under four percent ... , Asked whether the government had any benchmark to contain the ...
... and a veteran Orissa Congress leader died after a brief ... after his recent surgery and since then he was not ... and died before his family doctor could reach his residence, ... sons and four daughters. Mohapatra was elected to the Orissa ...
Cached Medicine News:Health News:Proposal to license Ayurveda Practitioners in the US 2
(Date:5/17/2013)... -- Boston Scientific Corporation (NYSE: BSX ) is ... May 21-24 in Paris . ... and diversified set of data this year at EuroPCR," ... chief medical officer, Boston Scientific.  "The primary endpoint results ... PROMUS trial, which evaluated our Promus PREMIER ™ ...
(Date:5/16/2013)... May 16, 2013  PTC Therapeutics, Inc., today announced ... S-1 with the U.S. Securities and Exchange Commission ("SEC") ... common stock. The number of shares to be offered ... been determined. (Logo:  http://photos.prnewswire.com/prnh/20010919/PTCLOGO ) ... as joint book-running managers for the offering. Cowen and ...
(Date:5/16/2013)... SYDNEY , May 16, 2013  HeartWare ... a leading innovator of less invasive, miniaturized circulatory support technologies ... announced that CEO Doug Godshall is ... at 11:00 a.m. EDT on Monday, May 20, 2013.  The ... New York Hotel. A live webcast of the ...
Breaking Medicine Technology:Boston Scientific Schedule of Major Events and Presentations at EuroPCR 2013 2Boston Scientific Schedule of Major Events and Presentations at EuroPCR 2013 3Boston Scientific Schedule of Major Events and Presentations at EuroPCR 2013 4Boston Scientific Schedule of Major Events and Presentations at EuroPCR 2013 5Boston Scientific Schedule of Major Events and Presentations at EuroPCR 2013 6Boston Scientific Schedule of Major Events and Presentations at EuroPCR 2013 7Boston Scientific Schedule of Major Events and Presentations at EuroPCR 2013 8PTC Therapeutics, Inc. Files Registration Statement for Proposed Initial Public Offering 2HeartWare Presentation At The 2013 UBS Global Healthcare Conference To Be Webcast 2
... Francisco, Inc. announced today that Michael Buckley, Ph.D., has ... Dr. Buckley will be responsible for directing all aspects ... for production of therapeutic antibody candidates at Takeda,s antibody ... "Mike brings over 20 years of experience in the ...
... Aprima Medical Software (originally iMedica), a ... management (PM) systems for medical practices, today announced that ... practice located in Bend, Oregon. Following years of ... after a positive experience with Aprima,s "Take-A-Tablet" program, a ...
Cached Medicine Technology:Takeda San Francisco, Inc. Appoints Michael Buckley, Ph.D. Vice President of Process Sciences 2Aprima's EHR Helps Bend Urology Associates Improve Efficiency, Workflow 2Aprima's EHR Helps Bend Urology Associates Improve Efficiency, Workflow 3
Cruciate retaining, posterior stabilized and constrained components....
The Natural-Knee Family is a complete range of interchangeable, anatomically-designed implants with over 14 years of proven clinical results....
... Solution tricompartmental total knee prosthesis stems from ... State-of-the-art design and manufacturing technologies have been ... function as well as a favorable pressure ... to keep wear to a minimum. The ...
...
Medicine Products: