Navigation Links
UCSF 'fountain of youth' pill could restore aging immune system
Date:12/13/2010

ing, examining their levels of key cytokines Interleukin (IL)-2, IFN-gamma and IL-17 and discovered that truly healthy 70-80 year old women had the same levels of those as did healthy 20 year olds.

However, elderly men and frail women who showed increased levels of inflammatory diseases and weakened defenses against infections tended to have lower levels of the first two cytokines, which are protective, and higher levels of IL-17, which is linked to inflammation. That imbalance, the researchers found, began in late middle age.

They then set out to find a drug that could raise IL-2 and IFN-gamma and either have no effect on IL-17 or lower it.

"We now had a profile in humans that we could take to test tubes to say, 'Does this drug have a desirable effect?'" Goetzl said. "Our job was to find a therapy that not only works, but does so at a dose range with no side effects."

The team focused on three classes of drugs, among them the one that includes lenalidomide a derivative of thalidomide which is undergoing a renaissance, Goetzl said.

First introduced in the late 1950s as a sedative, thalidomide was never approved in the United States, but was withdrawn from the world market in 1961 after causing severe birth defects in infants whose mothers took the drug to reduce nausea during pregnancy.

In recent years, however, lenalidomide has been found to be an effective co-therapy for some cancers, particularly multiple myeloma and kidney tumors, as well as leprosy, at doses of 5 mg to 20 mg per day. Those cancers are tied to a drop in IL-2, the main cytokine that Goetzl's team had linked to declines in aging immune systems.

In this study, the team tested the drug in healthy seniors, each of whom were matched in race, gender and national origin to a healthy young adult participant. They found that extremely low levels of lenalidomide 0.1 μM optimally stimulated IL-2 production in the young people
'/>"/>

Contact: Kristen Bole
kristen.bole@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Fountain of youth steroids could protect against heart disease
2. Research tackles drug use, HIV in South African youth
3. Researchers Assess Gay Youths Mental Health
4. Youth report favorable impressions of community street outreach workers
5. Youth Sports Injuries Reaching Epidemic Levels, Experts Report
6. Study finds family acceptance of LGBT youth protects against depression, substance abuse, suicide
7. Prescriptions for Stimulants, Painkillers Soaring Among Youth
8. Past Abuse Puts Homeless Youth at Risk for Early Sex: Study
9. Community rallies to fight obesity in Clevelands urban youth
10. Contraband cigarettes main source of supply for Ontario youth
11. For Many Gay Youth, Bullying Exacts a Deadly Toll
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UCSF 'fountain of youth' pill could restore aging immune system
(Date:3/2/2015)... (PRWEB) March 02, 2015 Ticket Down ... at the Hollywood Bowl . This popular site has ... appreciation promo code JIMMY-BUFFETT-2015 for added savings. , Parrotheads ... favorite performer will be headlining at the Hollywood Bowl ... will be on Thursday, October 22nd and it will ...
(Date:3/2/2015)... Raleigh, NC (PRWEB) March 02, 2015 ... response can be a better predictor of outcomes for ... here to read details of the new study ... and pathologists at the University of Eastern Piedmont followed ... underwent talc pleurodesis treatment for excess lung fluid. ...
(Date:3/2/2015)... Burns Engineering's Lab-to-Lab Calibration Service ... Standard Platinum Resistance Thermometers (SSPRTs) and industrial Resistance ... less . . . guaranteed. Their ... Code 200706-0), ISO 9001 and 17025 Certified and ... -196°C to 500°C, both ITS-90 and Callendar-van Dusen ...
(Date:3/2/2015)... 2015 The minimally invasive surgical ... CAGR of 6.1% to reach $14,133.0 million by ... Factors such as advantages of minimally invasive surgeries ... to minimally invasive surgeries and increasing number of ... the global minimally invasive surgical instruments market. , ...
(Date:3/2/2015)... (PRWEB) March 02, 2015 Four Seasons Resort ... celebrating its 25th anniversary this year, having officially opened its ... the luxury resort is honoring over 70 employees who started ... -- from amongst the approximately 400 original employees. The ... Resort’s Oceanfront Lawn. , This Four Seasons flagship ...
Breaking Medicine News(10 mins):Health News:Cheap Jimmy Buffett Tickets Hollywood Bowl: Ticket Down Slashes Prices on Jimmy Buffett Tickets at the Hollywood Bowl in Los Angeles/Hollywood, CA 2Health News:New Research Links Talc Treatment Response with Mesothelioma Prognosis, According to Surviving Mesothelioma 2Health News:Burns Engineering Announces Quick-Turn Temperature Calibrations 2Health News:Minimally Invasive Surgical Instrument Market - Global Forecast to 2019 - New Report by MarketsandMarkets 2Health News:Celebrating Four Seasons Resort Maui’s 25th Anniversary 2
... ... company, helps bring fresh, clean air into homes with permanent air-conditioning and furnace filters. ... RiteAir.com helps spare the environment from the excess waste caused by the ... method of cleaning indoor air. , ...
... ... with damaged or missing toenails can wear sandals without shame. The Just For Toenails Prosthetic ... , ... 27, 2010 -- Patients who have ugly toenails no longer have to hide their toes ...
... , ... card debt relief formula, developed by www.paymentreduction.com using latest debt settlement guidelines, ... more for high debt consumers starting to suffer financial hardship. , ... (PRWEB) April 27, 2010 -- High ...
... of patients worldwide participate in randomized clinical trials hoping ... someone else with the same condition. However, rules ... trials where resources are limited and risks may be ... "There is no question that research participants ...
... N.J. (April 26, 2010, 4 p.m. EDT) Myelodysplastic syndromes (MDS) ... nearly five times more common in seniors than previously thought, ... Theurer Cancer Center at Hackensack University Medical Center. The ... are at much higher risk for heart attack, diabetes and ...
... ... ... the age of 25, have a life story complete and compelling enough to command an ... lived a childhood of crisis, hardship and deliverance in a time of bloody political turmoil, ...
Cached Medicine News:Health News:RiteAir.com is the Right Solution for Green Living and a Clean Indoor Environment 2Health News:RiteAir.com is the Right Solution for Green Living and a Clean Indoor Environment 3Health News:Summer Sandal Time Is Here! Beautify Your Damaged Toenails At Your Podiatrist's Office 2Health News:Banks Flock to New Credit Card Debt Relief Formula that Shows Consumers how to Reduce Credit Card Debt for Pennies 2Health News:MDS, a blood cancer, strikes nearly 5 times more Americans than previously thought 2Health News:MDS, a blood cancer, strikes nearly 5 times more Americans than previously thought 3Health News:Autobiography Gives Child's Eye View of West African Regime Change and Family Fallout 2Health News:Autobiography Gives Child's Eye View of West African Regime Change and Family Fallout 3Health News:Autobiography Gives Child's Eye View of West African Regime Change and Family Fallout 4
(Date:3/2/2015)... 2, 2015  Kush Bottles, North ... solutions for the marijuana industry, announced today that ... been nominated for a 2015 Excellence in Entrepreneurship ... Award is designed to recognize individuals who exemplify ... their creativity and determination, have established and nurtured ...
(Date:3/2/2015)... , March 2, 2015  Maquet Medical Systems ... it has signed an exclusive distribution agreement with ... flagship product, the Flight 60 mechanical ventilator. The ... providing dependable and affordable mobility. Starting in the ... be sold in the United States ...
(Date:3/2/2015)... , March 2, 2015 Every ... population with nearly 38,000 of those ending ... Aureus), a highly contagious disease, infects approximately ... Each of these and more, not listed, ... casual contact with other infectious individuals, contact ...
Breaking Medicine Technology:Kush Bottles CEO, Nicholas Kovacevich, Nominated for 2015 "Excellence in Entrepreneurship Award" 2Maquet Medical Systems USA to Exclusively Distribute Flight Medical's Flight 60 Respiratory Ventilators 2Maquet Medical Systems USA to Exclusively Distribute Flight Medical's Flight 60 Respiratory Ventilators 3Cleanint Rolls Out Cleanstethoscope and Cleanhands to Largest Medical Transportation Company in the Nation 2Cleanint Rolls Out Cleanstethoscope and Cleanhands to Largest Medical Transportation Company in the Nation 3
... 2011 IBM (NYSE: IBM ) and ... NCD Challenge , a competition among a number ... of students to find new ways to address the rise ... (Logo: http://photos.prnewswire.com/prnh/20090416/IBMLOGO ) Illnesses such ...
... bio-pharmaceutical companies lose the ability to communicate externally because ... internal Advocacy groups will become more important to a ... cost effectiveness of care by communicating concepts and arranging ... Since internal Advocacy groups are not known ...
Cached Medicine Technology:IBM Launches University Competition to Combat Growth of Non-Communicable Diseases 2IBM Launches University Competition to Combat Growth of Non-Communicable Diseases 3Pharmaceutical Advocacy Groups Focus on Value-of-Care Initiatives 2
Gerald bayonet forceps. Insulated....
Scleral knives designed for trabeculectomy and groove type incisions, scleral standard USA size....
OKN drum...
Sterile squares of smooth foil for repair of the floor of the orbit and other plastic surgery. Available in large size....
Medicine Products: