UCSF faculty receive $13.7M from CIRM for stem cel...(known as small RNAs which he hypothesize...),Health

Date:8/19/2008

known as small RNAs, which he hypothesizes play a key role in controlling the expression of embryonic stem cells. Understanding the mechanisms that determine and maintain the potential of stem cells will allow the medical and pharmaceutical community to improve the efficiency with which they can produce embryonic stem cell lines, as well as quality control of the resulting cells, he says. ($3,029,897 grant)

Ophir Klein, MD, PhD -- He will explore the molecular processes that regulate the behavior of dental stem cells in mice, with the goal of promoting tooth regeneration and craniofacial abnormalities in humans. As the signaling pathways are similar to those of the liver and other organs, his work will shed light on regeneration of these organs, as well. His ultimate goal, he says, is to help lay the groundwork for growing human teeth and help advance efforts to regenerate larger organs. ($3,075,251 grant)

Emmanuelle Passegu, PhD -- She will study mouse blood stem cells to investigate how they thrive and, at times, accumulate damage that leads to cancer. Her goal is to identify molecular targets for preventing therapy-related organ damage or secondary cancers. She also will use her mouse model of human leukemia to study what molecular changes lead to cancer stem cell formation and function during disease development. The goal of this work would be to design novel therapies that target cancer stem cells while sparing normal stem cells. ($2,274,368 grant)

Jeremy Reiter, MD, PhD -- He will study the genes that contribute to the development of ALS and other forms of neurodegenerative motor diseases. Using a mouse model he developed, his team will examine the impact of mutant genes associated with the diseases on mouse embryonic stem cells, in order to identify the way in which they actually kill the cells. Diseased motor neurons grown in cell culture dishes could be quickly and efficiently screened with potential drugs to discover
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Contact: Jennifer O'Brien jobrien@pubaff.ucsf.edu 415-476-2557 University of California - San Francisco Source:Eurekalert

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