Navigation Links
UCSF faculty receive $13.7M from CIRM for stem cell research
Date:8/19/2008

Five UCSF stem cell scientists have received New Faculty grants from the California Institute for Regenerative Medicine, support that will allow them to pursue lines of investigation ultimately aimed at developing treatment strategies for such conditions as cancer, heart disease, tooth regeneration, liver disease and amyotrophic lateral sclerosis.

The UCSF grants, which range from about $2 million to $3 million each, total $13.7 million and are intended to support the scientists in the critical early stages of their careers as independent investigators establishing their own laboratories and research programs. CIRM will provide salary and research support for up to five years, creating a stable environment for the faculty to build innovative and robust stem cell research programs.

"These grants are a tremendous boon to the investigators, but also to the stem cell field overall," says Arnold Kriegstein, MD, PhD, director of the UCSF Institute for Regeneration Medicine. "They will fuel the research of some of the most creative stem cell scientists in the world, allowing them to pursue the significant scientific challenges they have set for themselves."

The grants, announced today, are the latest round of research funds awarded by the Independent Citizens Oversight Committee, which oversees CIRM. The ICOC awarded $59 million in New Faculty grants to research universities throughout California.

The UCSF researchers will use the funds to explore fundamental questions about the way in which embryonic stem cells function, how they are regulated and what molecular steps lead them to specialize as specific types of mature cells, such as liver cells. In each case, they plan to use the knowledge they gain to explore cell-replacement therapies or identify potential drugs to treat diseases.

The UCSF faculty recipients, their research areas, and grant amounts are:

  • Robert Blelloch, MD, PhD He will study molecules known as small RNAs, which he hypothesizes play a key role in controlling the expression of embryonic stem cells. Understanding the mechanisms that determine and maintain the potential of stem cells will allow the medical and pharmaceutical community to improve the efficiency with which they can produce embryonic stem cell lines, as well as quality control of the resulting cells, he says. ($3,029,897 grant)

  • Ophir Klein, MD, PhD -- He will explore the molecular processes that regulate the behavior of dental stem cells in mice, with the goal of promoting tooth regeneration and craniofacial abnormalities in humans. As the signaling pathways are similar to those of the liver and other organs, his work will shed light on regeneration of these organs, as well. His ultimate goal, he says, is to help lay the groundwork for growing human teeth and help advance efforts to regenerate larger organs. ($3,075,251 grant)

  • Emmanuelle Passegu, PhD -- She will study mouse blood stem cells to investigate how they thrive and, at times, accumulate damage that leads to cancer. Her goal is to identify molecular targets for preventing therapy-related organ damage or secondary cancers. She also will use her mouse model of human leukemia to study what molecular changes lead to cancer stem cell formation and function during disease development. The goal of this work would be to design novel therapies that target cancer stem cells while sparing normal stem cells. ($2,274,368 grant)

  • Jeremy Reiter, MD, PhD -- He will study the genes that contribute to the development of ALS and other forms of neurodegenerative motor diseases. Using a mouse model he developed, his team will examine the impact of mutant genes associated with the diseases on mouse embryonic stem cells, in order to identify the way in which they actually kill the cells. Diseased motor neurons grown in cell culture dishes could be quickly and efficiently screened with potential drugs to discover agents that slow, halt or reverse the cellular damage, he notes. ($2,259,092 grant)

  • Holger Willenbring, MD -- He will investigate the genes that establish the function of early-stage liver cells. His goal is to use this knowledge to prompt human embryonic stem cells to specialize as early-stage liver cells in the culture dish. If he succeeds, he'll transplant the cells into a mouse model of human liver disease. This would be proof of principle for the potential of embryonic stem cells for liver cell therapy, he says. ($3,032,510 grant)


'/>"/>

Contact: Jennifer O'Brien
jobrien@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
Source:Eurekalert

Related medicine news :

1. Johnson & Johnson Campaign for Nursings Future Joins With AACN to Offer New Minority Nurse Faculty Scholars Program
2. Eight Graduate Nursing Students Selected to Receive The California Endowment-AACN Minority Nurse Faculty Scholarship
3. Rutgers College of Nursing faculty member Rachel Jones wins New York Times Nurse Award
4. UNC faculty and students to develop plan to get clean water in poorer homes
5. UNT Health Science Center Appoints Eight New Faculty Members
6. Rutgers College of Nursing faculty member Rachel Jones awarded Rutgers-Newark Provost Award
7. Einstein honors Dr. Stanley Nathenson with Marshall S. Horwitz Faculty Prize for Research Excellence
8. AACN Concerned That the Presidents FY 2009 Budget Request Will Prolong the Nursing and Nurse Faculty Shortage
9. First Group of Minority Nurse Faculty Scholars Selected by the Johnson & Johnson Campaign for Nursings Future and AACN
10. APIC selected as faculty in Blue Shield of California Foundation initiative to fight HAIs
11. APIC Selected as Faculty in Blue Shield of California Foundation Initiative to Fight Healthcare-Associated Infections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2016)... , ... May 02, 2016 , ... Eating Recovery ... for eating, mood and anxiety disorders, has rebranded its eating disorder program under a ... residential eating disorder treatment facility on May 16. , To celebrate, ERC Chicago ...
(Date:5/2/2016)... ... 2016 , ... In honor of National Physical Fitness and Sports Month in ... their fitness journey on social media. , The foot care company, which specializes ... product voucher each week during May to one winner. , “Whether the goal is ...
(Date:5/2/2016)... CA (PRWEB) , ... May 02, 2016 , ... Dr. ... provide his patients with same day treatments. In the past, many necessary dental treatments ... or work, along with multiple anesthetic shots and extra chair time. Not only could ...
(Date:5/2/2016)... (PRWEB) , ... May 02, 2016 , ... MedPro Waste ... mail back service. MedPro now offers its mail back service for an all-inclusive ... we are now able to provide service to all of the clients in the ...
(Date:5/2/2016)... NV (PRWEB) , ... May 02, 2016 , ... ... Pharmacy Times, has announced a new Specialty Pharmacy Patient Satisfaction Award that will ... based on the quarterly results from Zitter Health Insights’ Specialty Pharmacy Patient Satisfaction ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... April 29, 2016 Acquisition ... Sciences, Product Development Capabilities in North ... Base . Indegene ( http://www.indegene.com ... the acquisition of Skura Corporation,s life science business. ... adaptive sales enablement technology for life science organizations ...
(Date:4/28/2016)... 2016  While Abbott,s announced purchase of St. ... repair and stent business, healthcare research firm Kalorama ... firmly into patient monitoring.  Kalorama said that patient ... areas, with double-digit growth expected the next 5 ... Remote Patient Monitoring . Abbott Laboratories agreed ...
(Date:4/28/2016)... , April 28, 2016 ... insights on healthcare, announced today that it has been ... Cool Vendor in Life Sciences, 2016, ... 2016.  The report focuses on life-science- oriented analytics, algorithms ... from patients and doctors, confirm medication ingestion, and analyze ...
Breaking Medicine Technology: