Navigation Links
UCSF collaborates with Zcube to develop new ways to deliver drugs
Date:2/28/2011

A pill filled with microscopic, drug-laden adhesive patches is at the center of an agreement between UCSF and Zcube srl, the research corporate venture arm of Italian pharmaceutical leader Zambon Co., SpA, to license UCSF-developed microtechnology and support early research into new ways to deliver oral medications directly to a targeted site in the body.

This is the first sponsored research agreement between Zcube and UCSF, but is expected to be one of several such agreements with the biomedical university.

Sponsored research agreements underscore UCSF's commitment to finding innovative ways to bridge the gap between basic research and real-world applications. They reflect continued efforts by the UCSF Office of Technology Management and Industry Contracts Division to help faculty research efforts bear fruit, while protecting the academic freedom and basic research for which UCSF is widely known.

The initial two-year agreement will support research in the UCSF Desai Laboratory into delivering drugs directly to the small intestine and colon. The exclusive, worldwide license agreement will offer milestone payments and royalties for a UCSF-patented microdevice developed by the Desai Laboratory to deliver medications for various diseases, including colitis and irritable bowel syndrome.

"This partnership is unusual because it goes beyond licensing a technology, to fund early-stage innovation in drug delivery systems," said Tejal Desai, PhD, a professor of Bioengineering and Therapeutic Sciences in the UCSF School of Pharmacy. "That research is exactly what we need to do to see whether these systems will work."

The microdevice resembles a tiny, square Band-Aid with reservoirs in the middle for medication. Hundreds of these structures, each as wide as a human hair, would be packaged into a normal-sized pill, which would break down and release them into the intestine. The micropads would then stick onto the gastro-intestinal tract and deliver medications directly into the intestinal lining, then dissolve.

As a result, Desai said, the device has the potential of targeting the colon directly and increasing drug safety by reducing the amount of medication required in each dose. When properly targeted to other intestinal areas, the device also can significantly increase the amount of medication that reaches a patient's bloodstream.

Innovative technology that markedly improves both existing medication and new therapeutic agents is a key focus for Zcube, according to Zcube General Manager Lorenzo Pradella, PhD.

"The technology Zcube licensed from UCSF is a fantastic innovation for the oral delivery of single and multiple therapies into the gastro-intestinal tract, being extremely beneficial to many patients for different diseases," Pradella said. "It confirms Zcube's efforts to support emerging life science technologies that can improve health into the future."

Zcube was founded in 2003 to support emerging life science technology and research worldwide, Pradella said. Since 2007, Zcube has placed particular emphasis on drug delivery systems and medical devices in different therapeutic fields. Zcube has established collaborations to that end with universities in Europe, the United States and Israel, as well as with Mission Bay Capital and the California Institute for Quantitative Biosciences (QB3), which is headquartered on the UCSF Mission Bay campus.


'/>"/>

Contact: Kristen Bole
kristen.bole@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert

Related medicine news :

1. PeopleStreme Collaborates with SkillSoft for Learning Management Content
2. Eisner USA, LLC Collaborates with Surgical Review Corp to Provide Innovative Bariatric Devices to Bariatric Surgery Center of Excellence (BSCOE) Participants
3. Philips Collaborates with Microsoft to Enhance Healthcare Efficiencies and Productivity
4. QB3 Adds Zcube As Limited Partner In Mission Bay Capital Fund
5. Team delivers development aid via cell phone animations
6. Top scientists unite to develop global scientific strategy Towards An HIV Cure
7. Family planning programs have success in developing countries, but need to be expanded
8. Cost-effectiveness research needs to be considered in developing new medical technology
9. Delivery Even a Bit Early May Mean Developmental Delays
10. Higher levels of social activity decrease the risk of developing disability in old age
11. Researchers develop outline that may help weigh benefits of new imaging technologies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now reveal their media with ... X," said Christina Austin - CEO of Pixel Film Studios. , ProSlice Color ... users can now reveal the media of their split screens with growing colorful ...
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... ... cutting edge technology to revolutionize the emergency ambulance transport experience for the millions ... aware of how Uber has disrupted the taxi industry through the use of ...
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A Forever Recovery, ... Festival and World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility ... home to some of the world’s leading providers of cereal and other breakfast foods. ...
(Date:6/26/2016)... ... ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop a weight ... app plans to fix the two major problems leading the fitness industry today:, ... program , They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... Austin, TX (PRWEB) , ... June 25, 2016 , ... ... Fellow of the American College of Mohs Surgery and to Dr. Russell Peckham for ... popular and highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- Research and Markets has announced ... Applications, Technologies, Forecasts" report to their offering. ... Smart Skin, Structural Health Monitoring, Composite Smart Structures, ... involves electronic and/or electrical components and circuits that ... such as vehicle bodies or conformally placed upon ...
(Date:6/24/2016)... India , June 24, 2016 ... Needles Market by Type (Standard Pen Needles, Safety Pen ... Therapy (Insulin, GLP-1, Growth Hormone), Mode of Purchase (Retail, ... by MarketsandMarkets, This report studies the market for the ... expected to reach USD 2.81 Billion by 2021 from ...
(Date:6/23/2016)... 2016 Research and Markets has announced ... Forecast to 2022" report to their offering. ... the patients with kidney failure, it replaces the function of ... patient,s blood and thus the treatment helps to keep the ... balance. Increasing number of ESRD patients & ...
Breaking Medicine Technology: