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UCSF Transgenic Mouse Mimics Parkinson's Earliest Symptoms
Date:5/4/2010

UCSF researchers have created the first transgenic mouse to display the earliest signs of Parkinson’s disease using the genetic mutation that is known to accompany human forms of the disease.

(Vocus) May 5, 2010 -- UCSF researchers have created the first transgenic mouse to display the earliest signs of Parkinson’s disease using the genetic mutation that is known to accompany human forms of the disease.

The mouse model, which expresses the same mutant proteins as human Parkinson’s patients, also displays early signs of constipation and other gastrointestinal problems that are a common harbinger of the disease in humans.

As a result, researchers say, these animals could serve as a means of investigating therapies for reversing the neurological dysfunction of the disease at its earliest stages.

The findings are featured as the cover story in the May 1, 2010 issue of the journal, “Human Molecular Genetics” and are available online at http://hmg.oxfordjournals.org/cgi/content/full/19/9/1633.

Researchers have long suspected that the neurological component of Parkinson’s, which causes tremors and stiffness among other symptoms, is actually a late-stage effect of a larger, systemic problem, according to UCSF geneticist Robert L. Nussbaum, MD, who was senior author on the paper.

“This new model validates that theory by mimicking what we know to be the genetic pathway leading to Parkinson’s, while also displaying the earliest symptoms that occur in humans,” said Nussbaum, who is the Holly Smith Distinguished Professor in Medicine and chief of the UCSF Division of Medical Genetics. “This will give us an important tool in identifying an early intervention for this devastating di
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