Navigation Links
UCSF Team Closer to Creating Safe Embryonic-Like Stem Cells
Date:4/13/2009

uce the next generation of mice.

"These are transient, non-coding molecules that do not incorporate into the genome, but promote self-replication and have the potential to induce pluripotency," Blelloch says. "They do their thing -- turn a somatic cell into an embryonic stem cell-like one -- and then they're gone."

"MicroRNAs give us a new tool to manipulate the fate of cells," Blelloch says.

MicroRNAs are snippets of single-stranded RNA that prevent a gene's code from being translated from messenger RNA into protein. They were debuted in 1993, when scientists reported the discovery of a microRNA in the microscopic roundworm C. elegans. Since then, the field has "exploded," says Blelloch, with hundreds of microRNAs discovered in the last eight years across a broad range of species, from plants to animals.

Produced in the nucleus and released into the cytoplasm, microRNAs home in on messenger RNAs that share part of their genetic sequence. When they find them, they latch on, preventing the messenger RNA from being processed by the protein-making machines known as ribosomes. As such, microRNAs are able to ratchet down a cell's production of a given protein.

Currently, Blelloch and his colleagues are working to replace all four transcription factors with microRNAs and conducting experiments that will reveal the mechanism by which these small molecules are able to induce pluripotency. The team will also be looking to determine which microRNAs might be able to turn adult cells directly into particular adult cell types, by-passing the embryonic stem cell-like stage altogether.

"The goal now is to ensure the safety of induced pluripotent stem cells and to differentiate them into cells that can be used to repair damaged tissue and treat disease," he says.

The study was supported by grants from the National Institutes of Health, California Institute for Regener
'/>"/>

Source: PRWeb
Copyright©2009 Vocus, Inc.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. UCSF team closer to creating safe embryonic-like stem cells
2. Yale Plans Closer Look at Exercise and Cancer
3. University of Washington scientists one step closer to stopping bone loss during spaceflight
4. Scientists closer to understanding how to control high blood sugar
5. Muscular dystrophy mystery solved; Mizzou scientist moves closer to MD solution
6. Video: Pampers Together with Actress Salma Hayek Helps UNICEF Move Closer Toward Goal of Eliminating Deadly Tetanus Through Global One Pack = One Vaccine Campaign
7. Pelosi: SCHIP Vote Brings Us One Step Closer to Providing Health Care for 11 Million Children
8. Health Plans, Employers Take Closer Look at Costs and Expand Disease Management Initiatives in Response to Diabetes Prevalence Increase
9. Molecular therapy for spinal muscular atrophy closer to clinical use
10. Decongestant Exposure Needs Closer Look
11. FDA Takes Closer Look at Wrinkle Treatments
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2015)... “ VXi BlueParott Reveal ” was ... Report, which features the latest and coolest technology products ... special reporter for NewsWatch, conducted the review and shared ... eliminating 90% of ambient noise. , Today, business is ... are important to any professional, voice calls are just ...
(Date:3/27/2015)... The Florida Center for Brain Tumor ... (ABC2), awarded $350,000 to support brain cancer research at ... Research Institute and H. Lee Moffitt Cancer Center and ... clear development path and potential to provide meaningful improvements ... , The awards fund research in areas on ...
(Date:3/27/2015)... 2015 The Thomas Scattergood ... grant-making foundation committed to raising its voice to ... delivered. , The Scattergood Foundation and The Kennedy ... Policy and Practice through the Annual Scattergood Foundation ... App is designed to guide the IBS sufferer ...
(Date:3/26/2015)... Elfster.com, the top-rated Secret Santa generator, ... list generator capabilities to its leading Secret Santa list ... list that one creates of things to do before ... the same name. Nowadays many millennials are creating ... summer achievements. , "We are greatly expanding our technology ...
(Date:3/26/2015)... 26, 2015 Dr. Rod J. ... Dallas Rhinoplasty Symposium and has trained over 6500 ... importance of evidence based medicine (EBM), that is, the ... conducted research. , "We often hear from rhinoplasty ... while we are certainly not trying to stifle these ...
Breaking Medicine News(10 mins):Health News:A Device to Tune out Background Noise was Recently Featured on NewsWatch Television 2Health News:The Florida Center for Brain Tumor Research and Accelerate Brain Cancer Cure Award $350,000 to Florida-Based Researchers 2Health News:The Florida Center for Brain Tumor Research and Accelerate Brain Cancer Cure Award $350,000 to Florida-Based Researchers 3Health News:SoundsLikeIBS Nominated For 3rd Annual Scattergood Innovation Award 2Health News:Plans for Bucket List Generator - Just In Time for Summer - Announced by Elfster 2Health News:Dr. Rod Rohrich Explores Evidence Based Innovations and Safety at the 32nd Annual Dallas Rhinoplasty Symposium 2
... under constant stress, could severely damage major organs and ... have warned. ,Stress may lead to unhealthy ... too much alcohol and not getting enough exercise - ... ,For some people, being under constant stress can ...
... of tea daily can protect you from developing skin cancer, ... to strengthen the findings. ,Tea's disease-fighting properties appear ... cell carcinomas - most common forms of skin cancers usually ... that grow slowly over a period of months or even ...
... found in human blood inhibited 60 strains of HIV ... study published Thursday in the journal Cell//, the San ... HIV strains that have developed resistance to existing medications ... new HIV/AIDS drugs -- the Chronicle reports. ...
... when thirty poor women of the fishing community, living on ... The 1994 Transplant of Human Organ Act ... allowed to donate kidneys for transplantation. However a recent report ... indicate that several leading hospitals in the state encouraged the ...
... Approximately 50% of sexually active gay men in the UK had ... of the 2005 Gay Men’s Sex Survey//, Consuming Passions, which has ... 40% of gay men in the UK are unaware of their ... have not disclosed their HIV infection status. ,The ...
... 4,000 pregnant women one-fifth of them had to undergo emergency ... Researchers found that obesity impairs the ability of the uterus ... deliver the baby. ,In a study of 4,000 ... women had to undergo an emergency Caesarean Section birth because ...
Cached Medicine News:Health News:Modern Lifestyle Could Damage Heart 2Health News:Peptide Found in Human Blood Inhibits 60 Strains of HIV, Study Says 2Health News:Kidney Trade: Curbing the Sale 2Health News:Kidney Trade: Curbing the Sale 3Health News:One-fifth of Obese Women Undergo Caesarean Due to Uterus Failure 2
(Date:3/26/2015)... March 26, 2015 Huntington Memorial Hospital is ... perform transcatheter aortic valve replacement (TAVR), a minimally invasive ... revolutionary new way to replace an aortic valve without ... lung machine. The procedure is performed by ... Azhil ( Alex) Durairaj , MD, interventional cardiologist and ...
(Date:3/26/2015)... 2015 Cardiologists at Beaumont Hospital, ... commercial implant of a device recently approved by the ... fibrillation. The Watchman Left Atrial Appendage Closure implant is ... to reduce the risk of stroke. Atrial ... more than 5 million Americans. Twenty percent of all ...
(Date:3/26/2015)... , March 26, 2015 Over-the-counter ... average American consumer. However, a new survey of ... ailments from the common cold to diabetes, can ... The research, conducted by the Private Label Manufacturers ... over-the-counter healthcare products, including those essential for treatment ...
Breaking Medicine Technology:Huntington Memorial Hospital Performs Groundbreaking Minimally Invasive Replacement of Heart Valves 2Beaumont Hospital, Royal Oak among first to offer alternative to blood-thinning medications for atrial fibrillation 2Beaumont Hospital, Royal Oak among first to offer alternative to blood-thinning medications for atrial fibrillation 3Consumers can keep over-the-counter medicine affordable by using store brands 2
... aureus and, Methicillin-Resistant Staphylococcus aureus from Positive ... BD Diagnostics, a segment,of BD (Becton, Dickinson and ... it,received clearance from the U.S. Food and Drug ... new assay is the first test available to,rapidly ...
... Dec. 27 Allos,Therapeutics, Inc. (Nasdaq: ALTH ... (DMC) has completed the pre-specified 65-patient,safety review of ... trial of,PDX (pralatrexate) in patients with relapsed or ... the trial continue per the,protocol. This interim assessment ...
Cached Medicine Technology:BD Announces FDA 510(k) Clearance of Two-Hour Test to Identify Superbug in Patients with Positive Blood Cultures 2BD Announces FDA 510(k) Clearance of Two-Hour Test to Identify Superbug in Patients with Positive Blood Cultures 3Interim Safety Analysis Supports Continuation of Allos Therapeutics' Pivotal Phase 2 PROPEL Trial of PDX in Patients with Peripheral T-cell Lymphoma 2Interim Safety Analysis Supports Continuation of Allos Therapeutics' Pivotal Phase 2 PROPEL Trial of PDX in Patients with Peripheral T-cell Lymphoma 3Interim Safety Analysis Supports Continuation of Allos Therapeutics' Pivotal Phase 2 PROPEL Trial of PDX in Patients with Peripheral T-cell Lymphoma 4Interim Safety Analysis Supports Continuation of Allos Therapeutics' Pivotal Phase 2 PROPEL Trial of PDX in Patients with Peripheral T-cell Lymphoma 5
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: