ing and follow-up medicinal chemistry. The center performs biochemical and cell-based assays using liquid handling robots and a screening library of more than 180,000 compounds. It also houses a group of medicinal chemistry researchers who optimize screening hits into drug leads. Over the past four years, the center has grown to 18 biologists and chemists, many with pharmaceutical experience.
The center is based on high-throughput screening, medicinal chemistry, and fragment-based screening, including a novel approach called “Tethering,” which Wells pioneered in his previous role as founder, president, and chief scientific officer at Sunesis Pharmaceuticals, Inc.
The center acts as a central research facility for scientists whose research would benefit from such technology. Its ultimate goal is to help pave the way for the discovery of new small molecules for research and potential therapeutics.
Small-molecule drugs -- which target a specific protein or enzyme that modulates a biochemical or cellular process and have the potential to alter disease states -- have traditionally been highly effective but are difficult to identify through standard, high-throughput screening.
QB3 is a cooperative effort among private industry and more than 200 scientists at UCSF, UC Berkeley and UC Santa Cruz. The institute harnesses the quantitative sciences of information technology, imaging and engineering to integrate and enhance scientific understanding of biological systems at all levels, enabling scientists to tackle problems that have been previously unapproachable. For more information, visit www.qb3.org.
The UCSF School of Pharmacy is the nation’s premier graduate-level school of pharmacy, the oldest pharmacy school in the western U.S., and a wellspring for discovery and innovation in the pharmaceutical sciences, education, and the p
Page: 1 2 3 4 Related medicine news :1
Copyright©2010 Vocus, Inc.
All rights reserved
. Dana Corporation, Inc. Enters Into Settlement Agreement With Dana Retiree Committee2
. PainCare Receives $14.4 Million in Cash From Completed Sale of South Florida Ambulatory Surgery Centers3
. Atlanta Falcons Physical Therapy Centers Set to Launch This Fall4
. Navitas Opens New Cancer Rehabilitation Center in Albuquerque in Conjunction With New Mexico Cancer Centers5
. Medicare Prescription Drug Benefit, Nonprofit Hospitals, Ambulatory Surgery Centers, Statistical Methods, and Pay-For-Performance Highlighted In the Latest INQUIRY Journal6
. Service-to-Sales Transformation at Contact Centers Hinges on Soft Skills7
. The First Incisionless Transoral Fundoplication for Treatment of Gastroesophageal Reflux is Performed in the U.S. at Ohio State University and Oregon Health & Science University Medical Centers8
. Community Health Centers Reveal Specific Ramifications of The Medicaid Citizenship and Identification Documentation Requirements9
. Commercial Insurers Reimbursement Rate to New Yorks Community Health Centers Jeopardizes Care10
. Pennsylvania Trauma Systems Foundation Accreditation Status for Trauma Centers11
. Vangent, Inc. Wins Spot on Centers for Medicare & Medicaid Services Enterprise System Development Contract