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UCSF, Stanford Study Reveals Neural Networks Targeted in Brain Diseases
Date:4/15/2009

s to some structural, metabolic or physiological aspect of neural network biology."

"We hope our finding will stimulate basic researchers to try to understand the molecular mechanisms for network-based neurodegeneration," he says.

Meanwhile, Seeley, Greicius, and their colleagues plan to test neural network-based diagnostic and disease-monitoring studies in younger people with genetic predispositions to Alzheimer's disease and frontotemporal dementia. The goal is to try to track incipient changes in neural network connectivity and, ultimately, to track how well new experimental drugs can repair or maintain connectivity once an individual begins to show signs of dysfunction.

"Our hope is to develop tools that can detect these diseases even before symptoms emerge, so that disease-modifying therapies can get started before it is too late," Seeley concludes.

Co-authors of the study were Richard K. Crawford, BS, Juan Zhou, PhD and Bruce L. Miller, MD, (Director), all of the UCSF Memory and Aging Center.

The study was funded by the National Institute of Aging, the National Institute of Neurological Diseases and the Larry L. Hillblom Foundation.

Related links:

UCSF's Seeley website:
http://neurology.ucsf.edu/seeley/index.html
UCSF Memory and Aging Center
http://memory.ucsf.edu

Stanford's Greicius website:
http://med.stanford.edu/profiles/Michael_Greicius/
Stanford Department of Neurology and Neurological Sciences
http://neurology.stanford.edu/


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