Navigation Links
UCSF, Stanford Study Reveals Neural Networks Targeted in Brain Diseases
Date:4/15/2009

The study, reported in the April 16 issue of the journal "Neuron," was conducted by scientists at the University of California, San Francisco and the Stanford University School of Medicine, who characterized their finding as "an important new framework for understanding neurodegenerative disease."

(Vocus) April 15, 2009 -- Scientists are reporting the strongest evidence to date that neurodegenerative diseases target and progress along distinct neural networks that normally support healthy brain function. The discovery could lead to earlier diagnoses, novel treatment-monitoring strategies, and, possibly, recognition of a common disease process among all forms of neurodegeneration.

The study, reported in the April 16 issue of the journal "Neuron," was conducted by scientists at the University of California, San Francisco and the Stanford University School of Medicine, who characterized their finding as "an important new framework for understanding neurodegenerative disease."

The finding inspired the image for the cover of the issue of the journal.

Researchers have known that neurodegenerative diseases are associated with misfolded proteins that aggregate within specific populations of neurons in the brain. Alzheimer's disease, for instance, results from misfolding events involving beta-amyloid and tau proteins, which result in neuritic plaque and neurofibrillary tangle formation in medial temporal memory structures. In all neurodegenerative diseases, synapses between nerve cells falter, and damage spreads to new regions, accompanied by worsening clinical deficits.

In most cases, however, scientists have not known what determines the specific brain regions affected by a disease. The current neuroimaging study, which examined patients with five forms of early age-of-onset dementia -- Alzheimer's disease, behavioral variant frontotemporal dementia, semantic dementia, progressive nonfluent aphasia, and corticobasal syndrome - as well as two groups of healthy controls, showed that each disease targets a different neural network.

"The study suggests that these diseases don't spread across the brain like a plaque but instead travel along established neural network pathways," says the lead author of the study, William W. Seeley, MD, assistant professor of neurology at the UCSF Memory and Aging Center.

Earlier work performed by Michael Greicius, MD, senior author and assistant professor of neurology and neurological sciences at Stanford, provided Seeley with the inspiration for the present study, which extended Greicius' work on Alzheimer's disease to a host of additional dementias. The findings suggest that network degeneration represents a class-wide neurodegenerative disease phenomenon.

"Something about a network's architecture or biology is either bringing the disease to networked regions or propagating disease between network nodes," says Seeley.

At this point, the scientists have shown that the diseases cause atrophy in networked regions. "We still need to determine how the diseases impact connectivity, and we don't yet know how, at the molecular level, disease spreads between networked areas," says Seeley.

Greicius further commented, "These results suggest that brain imaging measures of network strength should be sensitive enough to detect these diseases at an early stage and, as importantly, specific enough to reliably distinguish one disease from the others."

If all forms of neurodegenerative disease are propagated along synaptic connections, says Seeley, "the framework would have major mechanistic significance, predicting that the spatial patterning of disease relates to some structural, metabolic or physiological aspect of neural network biology."

"We hope our finding will stimulate basic researchers to try to understand the molecular mechanisms for network-based neurodegeneration," he says.

Meanwhile, Seeley, Greicius, and their colleagues plan to test neural network-based diagnostic and disease-monitoring studies in younger people with genetic predispositions to Alzheimer's disease and frontotemporal dementia. The goal is to try to track incipient changes in neural network connectivity and, ultimately, to track how well new experimental drugs can repair or maintain connectivity once an individual begins to show signs of dysfunction.

"Our hope is to develop tools that can detect these diseases even before symptoms emerge, so that disease-modifying therapies can get started before it is too late," Seeley concludes.

Co-authors of the study were Richard K. Crawford, BS, Juan Zhou, PhD and Bruce L. Miller, MD, (Director), all of the UCSF Memory and Aging Center.

The study was funded by the National Institute of Aging, the National Institute of Neurological Diseases and the Larry L. Hillblom Foundation.

Related links:

UCSF's Seeley website:
http://neurology.ucsf.edu/seeley/index.html
UCSF Memory and Aging Center
http://memory.ucsf.edu

Stanford's Greicius website:
http://med.stanford.edu/profiles/Michael_Greicius/
Stanford Department of Neurology and Neurological Sciences
http://neurology.stanford.edu/

Released jointly by University of California, San Francisco and Stanford University

Sources:
Jennifer O'Brien, UCSF
(415) 476-2557
Web: www.ucsf.edu

Bruce Goldman, Stanford School of Medicine
(650) 725-2106
Web: http://med.stanford.edu/

# # #

Read the full story at http://www.prweb.com/releases/UCSF/Stanford/prweb2324414.htm.


'/>"/>
Source: PRWeb
Copyright©2009 Vocus, Inc.
All rights reserved

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Stanford study highlights cost-effective method of lowering heart disease risks
3. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
4. MedHelp to Add Top Stanford Surgeons and Specialized Forums to Online Health Community
5. Molecular probe paints cancer cells in living animals, Stanford researchers find
6. Less than one-third of women aware of landmark hormone therapy study, Stanford researcher finds
7. IVF technique enables pregnancy without multiple births, Stanford researchers find
8. Stanford researchers find way to fight treacherous hepatitis B
9. Blood test takes step toward predicting Alzheimers risk, Stanford researchers find
10. Stanford researchers sniff out gene that gives dogs black fur
11. Stanford St. Jude Championship Presents $1.76 Million Donation To St. Jude Childrens Research Hospital(R)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... ... for mental health professionals, announced today its affiliation with Tennessee Counseling Association. ... solutions to the network of the Tennessee Counseling Association, adding exclusive benefits and ...
(Date:6/26/2016)... PLAINSBORO, N.J. (PRWEB) , ... June 27, 2016 , ... ... same sources, yet in many ways they remain in the eye of the beholder, ... Oncology (EBO), a publication of The American Journal of Managed Care. For the full ...
(Date:6/26/2016)... ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is ... a fitness app. The fitness app plans to fix the two major problems leading the ... one size fits all type program , They don’t eliminate all the reasons ...
(Date:6/25/2016)... ... 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to ... a new, often overlooked aspect of head lice: the parasite’s ability to live away from ... common occurrence, but a necessary one in the event that lice have simply gotten out ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. ... from injury. Recently, he has implemented orthobiologic procedures as a method for treating ... one of the first doctors to perform the treatment. Orthobiologics are substances that ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 Research ... World Market for Companion Diagnostic Tests" report to their ... Market for Companion Diagnostics The World Market ... and personalized medicine diagnostics. Market analysis in the report includes ... Test Market (In Vitro Diagnostic Kits) by Region (N. America, ...
(Date:6/24/2016)... 24, 2016  Arkis BioSciences, a leading innovator ... more durable cerebrospinal fluid treatments, today announced it ... funding is led by Innova Memphis, followed by ... private investors.  Arkis, new financing will accelerate the ... market release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... 2016 Research and Markets has ... by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), ... Parenteral) - Global Forecast to 2021" report to ... The global pharmaceutical excipients market is projected to reach ... 6.1% in the forecast period 2016 to 2021. ...
Breaking Medicine Technology: