Navigation Links
UCSD researchers receive $2.5 million in new stem cell grants

A pair of University of California San Diego researchers Martin Marsala, a specialist in spinal cord trauma and disorders, and Yang Xu, an immunologist have been awarded more than $2.5 million in new grants from the California Institute for Regenerative Medicine (CIRM).

The grants are two of 19 Stem Cell Transplantation Immunology awards totaling $25 million that were approved at the June 23 meeting of CIRM's Independent Citizens' Oversight Committee to fund work that translates basic research into clinical cures.

Marsala, MD, professor of anesthesiology in the UC San Diego School of Medicine, was awarded a grant worth more than $1.3 million to develop methods that would promote and prolong the survival of therapeutic stem cells grafted into the central nervous system, using few or no immunosuppressive drugs.

"Immunosuppressive drugs have many negative side effects," said Marsala. "If we can improve immune tolerance to specific cell lines, we may be able to develop therapies that are well-tolerated; which would have a significant impact for patients."

There are multiple prongs to Marsala's project. Researchers will test engraftment of three different neuronal precursor cell lines of human origin using an animal model. They will study the comparative survival of cells grafted into healthy and into injured spinal cord tissue. And they will test the engraftment success of genetically reprogrammed neuronal cells generated from pig skin cells.

Xu, PhD, a professor of biology at UC San Diego, and colleagues received a $1.2 million CIRM grant to exploring improving the human immune system's tolerance to grafted tissues derived from human embryonic stem cells (hESCs).

Xu's project involves developing an appropriate animal model for testing the idea of inducing tolerance by transplanting hESC-derived hematopoietic stem cells (multipotent stem cells that give rise to all blood cell types) into recipients prior to grafting other tissues derived from hESCs.

"Right now, rejection of grafted tissues expressing antigens from the donor can be delayed for a time if the immune system is persistently suppressed," said Xu. "But eventually, most grafts are rejected. And persistent immune suppression increases the risk for cancer and infection.

"By learning how to effectively generate and graft hESC-derived hematopoietic stem cells before other tissues are grafted, we hope to induce immune tolerance that would allow other transplanted hESC-derived cells to survive long-term and accomplish their missions."


Contact: Scott LaFee
University of California - San Diego

Related medicine news :

1. Researchers find key to getting estrogens benefits without cancer risk
2. Mount Sinai researchers find structural basis for incidence of skin cancers in a genetic disorder
3. WSU researchers find mothers of children with autism pay price in workplace
4. Free Resources from EBSCO Publishing Providing Useful Information to Researchers
5. University of Utah researchers fight genetic killer of infants and toddlers
6. Researchers identify key enzyme in melanoma cell development
7. Researchers predict human visual attention using computer intelligence for the first time
8. Montreal researchers shed light on common juvenile cancer
9. Early detection of cancer: The FDA approves procedure discovered by EPFL researchers
10. Researchers report new autism genes discovered
11. Simple eye test measures damage from multiple sclerosis, UT Southwestern researchers find
Post Your Comments:
(Date:10/13/2015)... ... October 13, 2015 , ... Purdue University announced Tuesday (Oct. ... Initiative aimed at enhancing Purdue’s life sciences research and graduate education. The initiative ... , The investment will result in cohesive efforts across several colleges and is ...
(Date:10/13/2015)... ... 13, 2015 , ... "My friend's son suffers from eczema, and he had ... an inventor from Platteville, Colo. "I came up with this kit as a way ... to prevent a child from rubbing or scratching his or her face. This protects ...
(Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... ProText Kinetic ... X . With ProText Kinetic Panel, users can create energetic text animations in any ... preset into the Final Cut Pro X timeline and stylize the text. With intuitive ...
(Date:10/13/2015)... ... October 13, 2015 , ... Relay (, a technology ... today a significant contract that will provide its award-winning private messaging solution to ... the growing success of its Relay program, IBX Wire™, which now has over ...
(Date:10/13/2015)... ... October 13, 2015 , ... Leading Internet marketing product review ... "Publish Academy" training course . Singal's new program, in which he reveals his ... around the Internet are weighing in with reviews. , "Considering the fairly high ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... 2015  Nanomedical Diagnostics, a biotech company developing ... diagnostics, announces the completion of a Series A ... Ventures. --> ... monitoring and diagnostic platforms that empower individuals to ... will enable the company to commercially release AGILE ...
(Date:10/13/2015)... Oct. 9, 2015 Research and Markets ( ... "Kombucha Market by Types (Bacteria, Yeast, Mold, Others), Flavors ... Flowers, Others), & by Region - Forecasts to 2020" ... --> --> The global ... few years. In terms of value, the market is ...
(Date:10/13/2015)... Oct. 13, 2015   Micell Technologies , Inc. ... and II trials of its MiStent Sirolimus Eluting Absorbable ... ) were presented at the 27th Annual Transcatheter Cardiovascular ... San Francisco , October 11-15. TCT is the ... MiStent SES was designed to optimize vessel healing in ...
Breaking Medicine Technology: