Navigation Links
UCSD researchers receive $2.5 million in new stem cell grants
Date:6/23/2010

A pair of University of California San Diego researchers Martin Marsala, a specialist in spinal cord trauma and disorders, and Yang Xu, an immunologist have been awarded more than $2.5 million in new grants from the California Institute for Regenerative Medicine (CIRM).

The grants are two of 19 Stem Cell Transplantation Immunology awards totaling $25 million that were approved at the June 23 meeting of CIRM's Independent Citizens' Oversight Committee to fund work that translates basic research into clinical cures.

Marsala, MD, professor of anesthesiology in the UC San Diego School of Medicine, was awarded a grant worth more than $1.3 million to develop methods that would promote and prolong the survival of therapeutic stem cells grafted into the central nervous system, using few or no immunosuppressive drugs.

"Immunosuppressive drugs have many negative side effects," said Marsala. "If we can improve immune tolerance to specific cell lines, we may be able to develop therapies that are well-tolerated; which would have a significant impact for patients."

There are multiple prongs to Marsala's project. Researchers will test engraftment of three different neuronal precursor cell lines of human origin using an animal model. They will study the comparative survival of cells grafted into healthy and into injured spinal cord tissue. And they will test the engraftment success of genetically reprogrammed neuronal cells generated from pig skin cells.

Xu, PhD, a professor of biology at UC San Diego, and colleagues received a $1.2 million CIRM grant to exploring improving the human immune system's tolerance to grafted tissues derived from human embryonic stem cells (hESCs).

Xu's project involves developing an appropriate animal model for testing the idea of inducing tolerance by transplanting hESC-derived hematopoietic stem cells (multipotent stem cells that give rise to all blood cell types) into recipients prior to grafting other tissues derived from hESCs.

"Right now, rejection of grafted tissues expressing antigens from the donor can be delayed for a time if the immune system is persistently suppressed," said Xu. "But eventually, most grafts are rejected. And persistent immune suppression increases the risk for cancer and infection.

"By learning how to effectively generate and graft hESC-derived hematopoietic stem cells before other tissues are grafted, we hope to induce immune tolerance that would allow other transplanted hESC-derived cells to survive long-term and accomplish their missions."


'/>"/>

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Related medicine news :

1. Researchers find key to getting estrogens benefits without cancer risk
2. Mount Sinai researchers find structural basis for incidence of skin cancers in a genetic disorder
3. WSU researchers find mothers of children with autism pay price in workplace
4. Free Resources from EBSCO Publishing Providing Useful Information to Researchers
5. University of Utah researchers fight genetic killer of infants and toddlers
6. Researchers identify key enzyme in melanoma cell development
7. Researchers predict human visual attention using computer intelligence for the first time
8. Montreal researchers shed light on common juvenile cancer
9. Early detection of cancer: The FDA approves procedure discovered by EPFL researchers
10. Researchers report new autism genes discovered
11. Simple eye test measures damage from multiple sclerosis, UT Southwestern researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/20/2017)... ... 21, 2017 , ... Nancy Johnston Toll marks her debut in ... Over the Bump in the Road ” (published by Xlibris). Inspired from her personal ... with the ups and downs experienced by anyone going through cancer treatment and how ...
(Date:2/20/2017)... , ... February 20, 2017 , ... Silverado today is ... to open and operate a state-of-the-art memory care community in Alexandria, Virginia. The new ... a site just outside of Old Town. , The three-story community with underground ...
(Date:2/20/2017)... (PRWEB) , ... February 20, 2017 , ... ... +1 (414) 213-8818 , Orbita, Inc., a leading provider of innovative software for ... for increasing patient engagement and optimizing care journey management for home healthcare. ...
(Date:2/20/2017)... ... February 20, 2017 , ... Clearwave ... technology that runs on the Posiflex XT-series of touch screen terminals. Both companies ... in Orlando, Florida. The terminal provider Posiflex is helping to bridge the ...
(Date:2/20/2017)... ... 2017 , ... Today, Biscom , the leader in ... IoT device from Biscom designed to deliver confidential patient information securely and quickly, ... HIMSS17 and will be conducting demonstrations at Booth #374. , With ...
Breaking Medicine News(10 mins):
(Date:2/21/2017)... Research and Markets has announced the addition ... Industry Forecast to 2025" report to their offering. ... The Global Apheresis Equipment Market ... the next decade to reach approximately $4.5 billion by 2025.  ... for all the given segments on global as well as regional ...
(Date:2/21/2017)... 21, 2017 Centurion Medical Products, a ... care, is making a major stride in emergency ... its IRIG-8™Wound Irrigation System . ... deliver copious volumes of irrigation solution to acute ... a significant improvement to the traditional syringe with ...
(Date:2/21/2017)... Research and Markets has announced the addition of the "EEG, ... to their offering. ... report provides separate comprehensive analytics for the US, Canada ... Asia-Pacific , Latin America , and Rest ... through 2022. Also, a six-year historic analysis is provided for these markets. ...
Breaking Medicine Technology: