Navigation Links
UCSD researchers receive $2.5 million in new stem cell grants
Date:6/23/2010

A pair of University of California San Diego researchers Martin Marsala, a specialist in spinal cord trauma and disorders, and Yang Xu, an immunologist have been awarded more than $2.5 million in new grants from the California Institute for Regenerative Medicine (CIRM).

The grants are two of 19 Stem Cell Transplantation Immunology awards totaling $25 million that were approved at the June 23 meeting of CIRM's Independent Citizens' Oversight Committee to fund work that translates basic research into clinical cures.

Marsala, MD, professor of anesthesiology in the UC San Diego School of Medicine, was awarded a grant worth more than $1.3 million to develop methods that would promote and prolong the survival of therapeutic stem cells grafted into the central nervous system, using few or no immunosuppressive drugs.

"Immunosuppressive drugs have many negative side effects," said Marsala. "If we can improve immune tolerance to specific cell lines, we may be able to develop therapies that are well-tolerated; which would have a significant impact for patients."

There are multiple prongs to Marsala's project. Researchers will test engraftment of three different neuronal precursor cell lines of human origin using an animal model. They will study the comparative survival of cells grafted into healthy and into injured spinal cord tissue. And they will test the engraftment success of genetically reprogrammed neuronal cells generated from pig skin cells.

Xu, PhD, a professor of biology at UC San Diego, and colleagues received a $1.2 million CIRM grant to exploring improving the human immune system's tolerance to grafted tissues derived from human embryonic stem cells (hESCs).

Xu's project involves developing an appropriate animal model for testing the idea of inducing tolerance by transplanting hESC-derived hematopoietic stem cells (multipotent stem cells that give rise to all blood cell types) into recipients prior to grafting other tissues derived from hESCs.

"Right now, rejection of grafted tissues expressing antigens from the donor can be delayed for a time if the immune system is persistently suppressed," said Xu. "But eventually, most grafts are rejected. And persistent immune suppression increases the risk for cancer and infection.

"By learning how to effectively generate and graft hESC-derived hematopoietic stem cells before other tissues are grafted, we hope to induce immune tolerance that would allow other transplanted hESC-derived cells to survive long-term and accomplish their missions."


'/>"/>

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Related medicine news :

1. Researchers find key to getting estrogens benefits without cancer risk
2. Mount Sinai researchers find structural basis for incidence of skin cancers in a genetic disorder
3. WSU researchers find mothers of children with autism pay price in workplace
4. Free Resources from EBSCO Publishing Providing Useful Information to Researchers
5. University of Utah researchers fight genetic killer of infants and toddlers
6. Researchers identify key enzyme in melanoma cell development
7. Researchers predict human visual attention using computer intelligence for the first time
8. Montreal researchers shed light on common juvenile cancer
9. Early detection of cancer: The FDA approves procedure discovered by EPFL researchers
10. Researchers report new autism genes discovered
11. Simple eye test measures damage from multiple sclerosis, UT Southwestern researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2017)... ... June 25, 2017 , ... CareSet Labs released the ... New Orleans. This is a new, greatly improved version of the Doctor Referral teaming ... requests by Fred Trotter and subsequently called the the “Doctor Referral Dataset” as released ...
(Date:6/24/2017)... (PRWEB) , ... June 24, 2017 , ... ... Dental365 family. Located at 217 Portion Road in Lake Ronkonkoma, Dental365 offers patients ... and weekends so that visits to the dentist fit into their patients’ busy ...
(Date:6/23/2017)... ... June 23, 2017 , ... By scoring 100% for fiscal ... four-star rating from premier online charity evaluator, Charity Navigator, validating ANRF's work as a ... all charities reviewed by Charity Navigator and earns ANRF a spot on their “ ...
(Date:6/23/2017)... ... June 23, 2017 , ... Military Connection ... denied entry to the JFK Virgin Atlantic lounge. , Bensko is no stranger ... six years ago, Bensko dedicated her life to supporting our wounded veterans. A world-class ...
(Date:6/23/2017)... (PRWEB) , ... June 23, 2017 , ... ... Breast Cancer Conference from Sept. 18 to 20. , The two-day conference is ... subtype with the goal of improving patients’ lives and eliminating racial breast cancer-related ...
Breaking Medicine News(10 mins):
(Date:6/7/2017)... 2017  Novavax, Inc., (Nasdaq: NVAX ) today ... trials of its RSV F protein recombinant nanoparticle vaccine candidate ... been published in the journal Vaccine ... prior scientific conferences). The Company previously announced top line ... developing the RSV F Vaccine with the goal of protecting ...
(Date:6/5/2017)... , June 5, 2017 Kohll,s Pharmacy ... the United States . The Raizer is ... a fallen person up to an almost-standing position ... and operated by one assistant and does not ... is simple enough that a child can operate it, ...
(Date:6/1/2017)... 2017 Nutriceutical Holdings (NH), parent company of ... and KD Pharma Group have decided to join forces ... Pharma Group. KD Pharma Group will become the largest ... the entire company. "We believe we have ... to growing the NH companies by providing us with ...
Breaking Medicine Technology: