Navigation Links
UCSD researchers receive $2.5 million in new stem cell grants

A pair of University of California San Diego researchers Martin Marsala, a specialist in spinal cord trauma and disorders, and Yang Xu, an immunologist have been awarded more than $2.5 million in new grants from the California Institute for Regenerative Medicine (CIRM).

The grants are two of 19 Stem Cell Transplantation Immunology awards totaling $25 million that were approved at the June 23 meeting of CIRM's Independent Citizens' Oversight Committee to fund work that translates basic research into clinical cures.

Marsala, MD, professor of anesthesiology in the UC San Diego School of Medicine, was awarded a grant worth more than $1.3 million to develop methods that would promote and prolong the survival of therapeutic stem cells grafted into the central nervous system, using few or no immunosuppressive drugs.

"Immunosuppressive drugs have many negative side effects," said Marsala. "If we can improve immune tolerance to specific cell lines, we may be able to develop therapies that are well-tolerated; which would have a significant impact for patients."

There are multiple prongs to Marsala's project. Researchers will test engraftment of three different neuronal precursor cell lines of human origin using an animal model. They will study the comparative survival of cells grafted into healthy and into injured spinal cord tissue. And they will test the engraftment success of genetically reprogrammed neuronal cells generated from pig skin cells.

Xu, PhD, a professor of biology at UC San Diego, and colleagues received a $1.2 million CIRM grant to exploring improving the human immune system's tolerance to grafted tissues derived from human embryonic stem cells (hESCs).

Xu's project involves developing an appropriate animal model for testing the idea of inducing tolerance by transplanting hESC-derived hematopoietic stem cells (multipotent stem cells that give rise to all blood cell types) into recipients prior to grafting other tissues derived from hESCs.

"Right now, rejection of grafted tissues expressing antigens from the donor can be delayed for a time if the immune system is persistently suppressed," said Xu. "But eventually, most grafts are rejected. And persistent immune suppression increases the risk for cancer and infection.

"By learning how to effectively generate and graft hESC-derived hematopoietic stem cells before other tissues are grafted, we hope to induce immune tolerance that would allow other transplanted hESC-derived cells to survive long-term and accomplish their missions."


Contact: Scott LaFee
University of California - San Diego

Related medicine news :

1. Researchers find key to getting estrogens benefits without cancer risk
2. Mount Sinai researchers find structural basis for incidence of skin cancers in a genetic disorder
3. WSU researchers find mothers of children with autism pay price in workplace
4. Free Resources from EBSCO Publishing Providing Useful Information to Researchers
5. University of Utah researchers fight genetic killer of infants and toddlers
6. Researchers identify key enzyme in melanoma cell development
7. Researchers predict human visual attention using computer intelligence for the first time
8. Montreal researchers shed light on common juvenile cancer
9. Early detection of cancer: The FDA approves procedure discovered by EPFL researchers
10. Researchers report new autism genes discovered
11. Simple eye test measures damage from multiple sclerosis, UT Southwestern researchers find
Post Your Comments:
(Date:11/27/2015)... , ... November 27, 2015 , ... MPWH, the No.1 Herpes-only dating community in the ... Table 1-1 ). More than 3.7 billion people under the age of 50 ... (HSV-1), according to WHO's first global estimates of HSV-1 infection . , "The data ...
(Date:11/27/2015)... ... November 27, 2015 , ... A simply groundbreaking television series, "Voices ... show that delves into an array of issues that are presently affecting Americans. Dedicated ... open dialogue, this show is changing the subjects consumers focus on, one episode at ...
(Date:11/27/2015)... Los Angeles, CA (PRWEB) , ... November 27, 2015 , ... ... the Commission on Accreditation of Allied Health Education Programs (CAAHEP) awarded accreditation to its ... exclusive list of CAAHEP accredited colleges, as only one of twelve colleges and universities ...
(Date:11/27/2015)... ... November 27, 2015 , ... Avid collector, Andrew Hawley from Vintage ... style concert posters. This is one of Joplin's most famous and beautiful concert posters. ... University of Michigan in Ann Arbor. The According to Hawley, "It is hard to ...
(Date:11/26/2015)... (PRWEB) , ... November 26, 2015 , ... Inevitably when ... Many customers choose to buy during the Black Friday and Cyber Monday ... don’t need to search the Internet high and low to find the best massage ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 26, 2015 /PRNewswire/ ... announced the addition of the  "2016 ... the Global Cell Surface Testing Market: ... report to their offering.  --> ... addition of the  "2016 Future Horizons ...
(Date:11/26/2015)... , November 26, 2015 /PRNewswire/ ... --> adds "Global ... and "Investigation Report on China Repaglinide ... 2021 forecasts data and information to ... . --> ...
(Date:11/25/2015)... DUBLIN , Nov. 25, 2015 /PRNewswire/ ... announced the addition of the "Global ... to their offering. --> ... "Global Brain Monitoring Devices Market 2015-2019" ... Research and Markets ( ) ...
Breaking Medicine Technology: