Navigation Links
UCSD researchers identify potential new drug target for chronic leukemia
Date:11/24/2008

Researchers at the University of California, San Diego (UCSD) and the Moores UCSD Cancer Center have discovered what could be a novel drug target for an often difficult-to-treat form of leukemia. The investigators have identified a unique "signature" or pattern of a specific family of enzymes in patients with chronic lymphocytic leukemia (CLL), the most common form of adult leukemia.

Paul Insel, M.D., professor of pharmacology and medicine at the UC San Diego School of Medicine and his co-workers compared white blood cells in patients with CLL to those of healthy adults. They found that one form of the group of enzymes, collectively known as cyclic nucleotide phosphodiesterases, was 10 times higher in CLL patients than in normal individuals. The specific type of enzyme, phosphodiesterase 7B (PDE7B), controls the levels of cyclic AMP (cAMP), a molecule that can promote programmed cell death, a process that is defective in CLL. The team reports its findings this week in the Proceedings of the National Academy of Sciences.

Whereas most cancers have out-of-control cell growth, CLL is characterized by an overabundance of white blood cells that do not die when they should, Insel explained.

The scientists subsequently tested the effects of drugs that blocked PDE7B in CLL cells, and found that this raised cAMP levels and caused CLL cells to undergo cell death. He explained that since PDE7B degrades cAMP, blocking PDE7B in essence takes the clamp off of programmed cell death, enabling CLL cells to die.

"PDE7B is thus a new drug target for CLL," he said. "We have preliminary data from patient samples studied in the laboratory showing that we can increase the killing of CLL cells even more if we block PDE7B and also add other drugs used to treat CLL."

He noted that a test for PDE7B might also potentially be used as a way to detect CLL, though this has yet to be proven. CLL, which usually strikes adults over age 35, ha
'/>"/>

Contact: Steve Benowitz
sbenowitz@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related medicine news :

1. USC researchers identify novel approach for suppressing prostate cancer development
2. Researchers identify new leprosy bacterium
3. UT Southwestern researchers develop new strategy for broad spectrum anti-viral drugs
4. Researchers discover strategy for predicting the immunity of vaccines
5. Ability to quit smoking may depend on ADHD symptoms, Columbia researchers find
6. Researchers ID Suite of Genes in Aging Process
7. Researchers: Ban on fast food TV advertising would reverse childhood obesity trends
8. Brigham and Womens Researchers Partner with Vocantas to use CallAssure in Clinical Research Study
9. Leeds researchers reshape the future of drug discovery
10. UNC researchers find clue to stopping breast-cancer metastasis
11. U of U researchers to use patients own stem cells to treat heart failure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... the premier women’s dress supplier, has recently released its ... of AngelWeddingDress.com to find more details. , Many ... a bridal party. AngelWeddingDress offers a variety of gorgeous ... wedding dresses are specially designed for 2015. , AngelWeddingDress ...
(Date:1/22/2015)... Juvent Sports ( http://www.juventsports.com ) and David ... Show to bestow a Juvent Sports Achievement award upon ... McKitrick. The award commemorated and congratulated McKitrick for her ... won her first amateur tournament in 1979 and most ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Thousand of ... Medical Care recalled its GranuFlo and NaturaLyte dialysis concentrates ... underway in U.S. District Court, District of Massachusetts, Bernstein ... 20th, the Court has remanded a case filed by ...
(Date:1/22/2015)... Oceanside,CA (PRWEB) January 22, 2015 For over 20 ... the Oceanside and Vista area has treated just about ... other personal injury circumstances. And for those same twenty-plus years, ... victims of all those injuries with the best possible doctor. ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Joan Lunden, ... keynote speaker at the upcoming 32nd Annual Miami ... Physicians’ Education Resource®, LLC (PER®) , shares that ... have gone undetected if she had not followed up ...
Breaking Medicine News(10 mins):Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 4Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6
... U.S. Secretary of Labor Elaine L. Chao today announced the ... on Occupational Safety and Health (NACOSH). The committee, established ... the Secretaries of labor and health and human services on ... , "We appreciate the advisory committee members, willingness ...
... Henry Mayo Newhall Memorial,Hospital in Valencia, California, has received ... $300 million master plan. The plan calls for the,development ... buildings, plus a,helipad and new parking structures. , ... not-for-profit hospital has seen tremendous growth in,the surrounding Santa ...
... UPTON, NY - Four physicists at the U.S. Department ... U.S. Patent No. 7,432,516 B2 for the design of ... proton radiation to cancerous tumors with minimal damage to ... precise and less costly than existing proton-therapy systems, potentially ...
... Ohio and PHOENIX, Nov. 25 There is a new,Internet ... the family,s basic need to stay informed, it allows,long-term care ... web page, by email and text message without families having,to ... Too much to do and too little ...
... The latest innovations in fluoroscopy, interventional radiology, and digital ... , MALVERN, Pa., Nov. 25 ... ) covers the entire spectrum of radiology, from fluoroscopy ... Scientific Assembly and Annual Meeting of the Radiological Society ...
... (Nasdaq: IDIX ) announced today that Idenix management ... Wednesday, December 3, 2008 at 4:30p.m. ET at The New ... , The live and archived webcast of ... in the Idenix Investor Center at www.idenix.com . ...
Cached Medicine News:Health News:U.S. Labor Secretary Elaine L. Chao announces new membership of OSHA advisory committee 2Health News:U.S. Labor Secretary Elaine L. Chao announces new membership of OSHA advisory committee 3Health News:Henry Mayo Newhall Memorial Hospital to Proceed With Master Plan 2Health News:Henry Mayo Newhall Memorial Hospital to Proceed With Master Plan 3Health News:Physicists receive patent for improved cancer therapy device 2Health News:Physicists receive patent for improved cancer therapy device 3Health News:New Internet Service Delivers Relief to Families of Those in Long-Term Care 2Health News:Siemens Demonstrates Flexibility, Enhanced Workflow and Imaging Excellence 2Health News:Siemens Demonstrates Flexibility, Enhanced Workflow and Imaging Excellence 3Health News:Siemens Demonstrates Flexibility, Enhanced Workflow and Imaging Excellence 4Health News:Siemens Demonstrates Flexibility, Enhanced Workflow and Imaging Excellence 5Health News:Siemens Demonstrates Flexibility, Enhanced Workflow and Imaging Excellence 6
(Date:1/23/2015)... , Jan. 23, 2015  Pete Rose, baseball,s all-time hits leader, ... arthritis pain reliever Myoflex, Ducere Pharma has announced. ... are excited to have him on board with Myoflex," said ... is a legendary player who is known across all generations. ...
(Date:1/23/2015)... LAS VEGAS , Jan. 23, 2015 Cord Blood ... CBAI ) ("CBAI" or the "Company")  filed a Preliminary Proxy ... ( www.sec.gov ) today, and provides an update for shareholders ... authorized shares is requested. Dear Shareholders, ...
(Date:1/23/2015)... , January 23, 2015 Heptares Therapeutics, ... delighted to announce that the Malcolm Campbell Memorial ... (Vice President of Chemistry), Fiona Marshall (Chief ... Executive Officer and co-founder) for the seminal contributions to GPCR ...
Breaking Medicine Technology:Pete Rose bets on Myoflex to relieve aches and pains 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 3Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 4Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 2Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 3Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 4
... 2011 Kensey Nash Corporation (Nasdaq: KNSY ) ... (SBIR) grant from the National Institutes of Health (NIH). ... $1.9 million Phase II SBIR grant to further investigate the ... repair procedures.  The Company will develop and evaluate the ability ...
... Nov. 7, 2011 /PRNewswire-Asia-FirstCall/ -- Tianyin Pharmaceutical Inc. (NYSE ... specializes in patented biopharmaceutical medicine, modernized traditional Chinese medicine ... announced that the earnings conference call for the first ... will be held at 8:30 a.m. Eastern Time on ...
Cached Medicine Technology:TPI to Host First Quarter Fiscal Year 2012 Earnings Conference Call on Monday, November 14, 2011 at 8:30 a.m. ET 2
Individually, self-contained, stackable drawers....
Shandon Wooden Slide File Storage Box...
Modular Specimen Filing System has five cells that can hold either slides or tissue cassettes....
... expanded database containing over 330 species ... VITEK 2 Compact offers enhanced identification ... time (2 to 14 hours), it ... that contaminate production areas and final ...
Medicine Products: