Navigation Links
UCSD researchers identify potential new drug target for chronic leukemia
Date:11/24/2008

Researchers at the University of California, San Diego (UCSD) and the Moores UCSD Cancer Center have discovered what could be a novel drug target for an often difficult-to-treat form of leukemia. The investigators have identified a unique "signature" or pattern of a specific family of enzymes in patients with chronic lymphocytic leukemia (CLL), the most common form of adult leukemia.

Paul Insel, M.D., professor of pharmacology and medicine at the UC San Diego School of Medicine and his co-workers compared white blood cells in patients with CLL to those of healthy adults. They found that one form of the group of enzymes, collectively known as cyclic nucleotide phosphodiesterases, was 10 times higher in CLL patients than in normal individuals. The specific type of enzyme, phosphodiesterase 7B (PDE7B), controls the levels of cyclic AMP (cAMP), a molecule that can promote programmed cell death, a process that is defective in CLL. The team reports its findings this week in the Proceedings of the National Academy of Sciences.

Whereas most cancers have out-of-control cell growth, CLL is characterized by an overabundance of white blood cells that do not die when they should, Insel explained.

The scientists subsequently tested the effects of drugs that blocked PDE7B in CLL cells, and found that this raised cAMP levels and caused CLL cells to undergo cell death. He explained that since PDE7B degrades cAMP, blocking PDE7B in essence takes the clamp off of programmed cell death, enabling CLL cells to die.

"PDE7B is thus a new drug target for CLL," he said. "We have preliminary data from patient samples studied in the laboratory showing that we can increase the killing of CLL cells even more if we block PDE7B and also add other drugs used to treat CLL."

He noted that a test for PDE7B might also potentially be used as a way to detect CLL, though this has yet to be proven. CLL, which usually strikes adults over age 35, ha
'/>"/>

Contact: Steve Benowitz
sbenowitz@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related medicine news :

1. USC researchers identify novel approach for suppressing prostate cancer development
2. Researchers identify new leprosy bacterium
3. UT Southwestern researchers develop new strategy for broad spectrum anti-viral drugs
4. Researchers discover strategy for predicting the immunity of vaccines
5. Ability to quit smoking may depend on ADHD symptoms, Columbia researchers find
6. Researchers ID Suite of Genes in Aging Process
7. Researchers: Ban on fast food TV advertising would reverse childhood obesity trends
8. Brigham and Womens Researchers Partner with Vocantas to use CallAssure in Clinical Research Study
9. Leeds researchers reshape the future of drug discovery
10. UNC researchers find clue to stopping breast-cancer metastasis
11. U of U researchers to use patients own stem cells to treat heart failure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... AstraZeneca’s Pulmicort is an ICS ... is used prophylactically for the maintenance treatment of ... budesonide, is an anti-inflammatory corticosteroid with a high ... includes the Pulmicort Flexhaler (budesonide) for adults and ... Pulmicort Respules for children between one and eight ...
(Date:9/21/2014)... than a quarter of house fires are started by ... ways. The first type of dryer fire occurs when the ... dryer fire occurs when lint builds up in the dryer vent ... malfunctioning electrical systems so if it doesn’t appear to be working ... some ways that you can prevent dryer fires. , Clean the ...
(Date:9/21/2014)... Burnaby Physiotherapists at Absolute PhysioCare & Sports ... to help them with preventative care. This is part ... will help clients understand their problem in a better ... in the healing process. With higher knowledge of their ... to facilitate the therapy that is initiated by the ...
(Date:9/21/2014)... New York (PRWEB) September 21, 2014 ... of their Risk Management Portal designed for Diocesan ... with the intent to support effective risk management ... scheduled to go live coinciding with Waldorf’s exhibition ... 21-24, 2014. , These applications were developed in ...
(Date:9/21/2014)... 2014 The asthma market saw ... it has become saturated with relatively efficacious standard ... (ICSs), inhaled corticosteroids and long-acting beta-agonists (ICS/LABAs), and ... generic competition. However, the launch of seven novel ... therapies delivered by the next-generation inhalers will strongly ...
Breaking Medicine News(10 mins):Health News:Pulmicort Asthma Market (Epidemiology, Etiology, Symptoms, Diagnosis, Pathology) Forecasts to 2023 in New Report Available at LifeScienceIndustryResearch.com 2Health News:Pulmicort Asthma Market (Epidemiology, Etiology, Symptoms, Diagnosis, Pathology) Forecasts to 2023 in New Report Available at LifeScienceIndustryResearch.com 3Health News:Pulmicort Asthma Market (Epidemiology, Etiology, Symptoms, Diagnosis, Pathology) Forecasts to 2023 in New Report Available at LifeScienceIndustryResearch.com 4Health News:Restoration Local Offers Tips to Avoid Dryer Fires 2Health News:Restoration Local Offers Tips to Avoid Dryer Fires 3Health News:Burnaby Physiotherapists Now Provide Educational Information for Preventative Care 2Health News:Waldorf Risk Solutions Releases New Risk Management Portal 2Health News:Spiriva Asthma Market (Tiotropium Bromide) Analysis and Forecasts to 2023 in New Report Available at LifeScienceIndustryResearch.com 2Health News:Spiriva Asthma Market (Tiotropium Bromide) Analysis and Forecasts to 2023 in New Report Available at LifeScienceIndustryResearch.com 3Health News:Spiriva Asthma Market (Tiotropium Bromide) Analysis and Forecasts to 2023 in New Report Available at LifeScienceIndustryResearch.com 4
... 7-9 in Las Vegas , ... Denver -- As part of its ... Water Works Association (AWWA), the authoritative resource on safe water, today ... , Oct. 7-9, 2009, in Las Vegas., , , , ,Debuted last ...
... comes as use of stimulant for enhanced mental function is ... -- A drug used to treat narcolepsy is increasingly being ... evidence that it also harbors the potential for abuse. , ... brain, the new study shows. , "This drug does seem ...
... Carestream Health, Inc. is a leading provider of dental and medical ... ... NY (PRWEB) March 17, 2009 -- Carestream Health, Inc., announced new ... (DR) imaging systems that provide direct digital capture of medical x-ray ...
... The Netherlands A number of updated guidelines will be ... of Urology (EAU) held in Stockholm, from 17 though 21 ... based on the extended text documents will also be available ... of clinical guidelines is one of the core activities of ...
... Ill., March 17 It happens in an instant, standing ... Vice President Joe Biden,s mother. For 92 year old ... guarding against taking a tumble is fast becoming a full ... now take added precautions to help prevent a fall and ...
... tobacco, and drug useOLYMPIA, Wash., March 17 A ... good choices about their health. Still, far too many ... behavior.The Healthy Youth Survey focuses on health risk behaviors. ... by more than 210,000 public school kids around the ...
Cached Medicine News:Health News:AWWA partners with WaterSmart Innovations conference 2Health News:Narcolepsy Drug Might Be Addictive 2Health News:Narcolepsy Drug Might Be Addictive 3Health News:Carestream Health Announces New Orders From from U.S. Healthcare Facilities For for Its Digital Radiography Solutions 2Health News:EAU launches new clinical guidelines for 2009 -- kidney cancer 2Health News:Safety Alert: From the American Academy of Orthopaedic Surgeons 2Health News:New Survey Results Give a Window Into Teen Behavior and Risks 2Health News:New Survey Results Give a Window Into Teen Behavior and Risks 3
(Date:9/19/2014)... 2014 UBM Medica US announces that  ... to help oncologists and other clinicians gain a better ... of targeted therapies and immunotherapies, discusses some of the ... Every September, Blood Cancer Awareness Month ... about blood cancers—helping to increase survival rates and improve ...
(Date:9/19/2014)... 19, 2014  Pressure BioSciences, Inc. (OTCQB: PBIO) ... received and approved all parts required to build ... begun to manufacture the new PCT-based instrument system.  ... ready for shipment by mid-October and that additional ... a rate of about one per week thereafter.  ...
(Date:9/19/2014)... , Sept. 19, 2014  Over 200 runners ... Future to Benefit the Radiation Oncology Institute (ROI), hosted ... at Golden Gate Park in San Francisco.  ... Moore , CEO of Radiation Business Solutions, "but ... have raised over $70,000 for the ROI this year. ...
Breaking Medicine Technology:OncoTherapy Network Highlights National Blood Cancer Awareness Month 2OncoTherapy Network Highlights National Blood Cancer Awareness Month 3OncoTherapy Network Highlights National Blood Cancer Awareness Month 4Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 2Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 3Fifth Annual 5K Run for the Future to Benefit the Radiation Oncology Institute Breaks Attendance, Donation Records 2Fifth Annual 5K Run for the Future to Benefit the Radiation Oncology Institute Breaks Attendance, Donation Records 3
... CHADDS FORD, Pa., Oct. 22 Endo Pharmaceuticals (Nasdaq: ... and Company 21st Annual Healthcare Conference on Tuesday, November 2, 2010, ... Endo, will review the company,s products and development programs. ... from Endo,s website at www.endo.com under the investors section. ...
... Pharmaxis (ASX: PXS) today announced significant results of pooled ... III trials of Bronchitol (inhaled mannitol) in people with ... presented for the first time at the North American ... addition, more results from the second trial (CF302) have ...
Cached Medicine Technology:Pharmaxis Announces Positive Combined Phase 3 Cystic Fibrosis Trial Results 2Pharmaxis Announces Positive Combined Phase 3 Cystic Fibrosis Trial Results 3Pharmaxis Announces Positive Combined Phase 3 Cystic Fibrosis Trial Results 4Pharmaxis Announces Positive Combined Phase 3 Cystic Fibrosis Trial Results 5
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: