Navigation Links
UCSD receives NIH Transformative R01 Award for stimulation of neuron regeneration in the retina

A research team led by principal investigator Kang Zhang, MD, PhD, professor of ophthalmology at the University of California, San Diego's Shiley Eye Center and director of UCSD's Institute of Genomic Medicine, has been awarded a five year, $4.66 million NIH Transformative Award.

Zhang and co-principal investigators Sheng Ding, PhD, from The Scripps Research Institute, and Thomas Reh, PhD from the University of Washington, received the highest possible scores for their proposal to investigate the regenerative potential of retinal cells. Their long-term goal is to restore visual function lost through diseases such as macular degeneration and retinitis pigmentosa.

"The success of this work could mean a paradigm shift in how retinal disease is treated, and could have broad and profound impact on human disease therapies by utilizing the regenerative power of our own cells," said Zhang.

Some vertebrates, such as goldfish and newts, have a remarkable ability to regenerate a lost limb or eye something it was thought no mammal can do. However, they recently showed proof of principle at a small scale level in mice by turning Muller cells into a type of retinal neuron.

"The human genome is quite similar to that of a newt, but we humans seem to have lost the potential to regenerate our own cells, possibly due to some inhibitory mechanims," Zhang said. "We are seeking small molecule chemicals that can block these inhibitions and consequently unlock humans' regenerative potential."

The Transformative Award program, funded through the Office of the NIH Director and the Common Fund, is intended "to support research that has the potential to transform the way we think about and conduct science, so the recipients represent an elite few with truly bold ideas," according to Francis Collins, Director of the National Institutions of Health.

The researchers are looking at particular kinds of cells called Muller cells, which are abundant and have the ability to regenerate nerve cells after retinal injury in fish, they usually play a supporting role in the central nervous system neurons of humans, such as those present in the eye or brain. This study proposes to use chemicals to turn Muller cells into photoreceptors in the eye cells that are lost in two diseases that are leading causes of blindness, macular degeneration and retinitis pigmentosa.

Identification of chemicals for Muller cells reprogramming and differentiation will provide new avenues in developing cell-based therapy as well as small molecule drugs for regenerative medicine, and facilitate new understanding of the mechanisms of trans-differentiation, according to the scientists. They plan to screen more than 100,000 compounds in order to identify the chemicals that prompt mouse Muller glia to develop new neurons, conferring the power of regeneration to the mammalian retina.

"Our ultimate goal is to use a chemical approach to turn on the regenerative potential of hibernating stem cells such as Muller cells by introducing a small molecule directly into the eye, perhaps even by eye drop or pill," said Zhang. He added that, since there is no need to transplant cells instead the body's own cells would be used, the therapy wouldn't have the risk of rejection or tumors.

Larry Goldstein, PhD, director of UC San Diego's stem cell program commented, "If this approach proves successful, it will have important applications in the field of regenerative medicine. If a patient's cells could be safely and effectively reprogrammed into retinal cells, it would serve as valuable first step towards developing novel treatments for vision loss.

Project Summary

Retinal photoreceptors are light-sensing cells that convert complex external visual stimuli to electrical and chemical signals. Degeneration of these photoreceptors is the end point of the most common forms of irreversible blindness in humans, including age-related macular degeneration and retinitis pigmentosa, which affect more than 50 million people worldwide.

In non-mammalian vertebrates such as fish, resident Muller glia cells in the retina have the ability to proliferate and differentiate into all retinal cell types, including photoreceptors; as a result, visual function is restored. However, this regenerative potential is almost non-existent in mammals.

By developing and applying high-throughput screening, the team hopes to identify small molecules that will enhance Muller glia cells' ability to reprogram and differente into retinal neurons in mammals. Identification, optimization and characterizations of chemical tools will provide new avenues for development of cell-based therapy as well as conventional small molecule therapeutics for regenerative medicine with the hoped-for result of restoring visual function lost in patients with severe blindness.


Contact: Debra Kain
University of California -- San Diego

Related medicine news :

1. NACDD Receives Two-Year Grant From Merck & Co., Inc. to Improve Diabetes Education
2. Dr Yaghouti of Global Laser Vision Receives Patient's Choice Award for 2009
3. UT researcher receives $2.4 million to research obesity, high-risk pregnancy
4. Receives Award for Customer Trust
5. Corporate Wellness Firm Limeade Receives SAS 70 Type II Report
6. Oridion Receives Frost & Sullivan's 2010 Customer Value Enhancement Award
7. Special Olympics Georgia Receives Grant from The Home Depot Foundation
8. NOVAVAX, Inc. Receives NASDAQ Non-Compliance Letter
9. WuXi PharmaTech Receives AAALAC Accreditation for Suzhou Toxicology Facility
10. Verdan Receives Patent on Crystal Deodorant Spray
11. Thomas E. Mower Meets With Dalai Lama; Receives Prestigious Champion Award from Whole Child International
Post Your Comments:
Related Image:
UCSD receives NIH Transformative R01 Award for stimulation of neuron regeneration in the retina
(Date:6/26/2016)... ... ... blind and certified personal trainer is helping to develop a weight loss fitness plan that ... the two major problems leading the fitness industry today:, , All ... They don’t eliminate all the reasons people quit their exercise program , ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX ... Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over ... Cut Pro X . Simply select a ProHand generator and drag it above media ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits ... terms of the latter, setting the bar too high can result in disappointment, perhaps ... slow progress toward their goal. , Research from reveals that ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary ... Dallas that it will receive two significant new grants to support its work ... marked its 25th anniversary by recognizing patients, medical professionals and scientists for their ...
(Date:6/24/2016)... ... 24, 2016 , ... People across the U.S. are sharpening their pencils and ... essay contest in which patients and their families pay tribute to a genetic counselor ... National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Research and Markets has announced the addition ... to their offering. The ... commercial environment for MedImmune to enter. The US ageing population ... to drive considerable growth for effective anti-influenza medications. The introduction ... considerably, but development is still in its infancy. ...
(Date:6/23/2016)... , , , WHEN: , , ... , , , LOCATION: , , , Online, with free registration ... PANELISTS:  , , , Frost & Sullivan,s Global Vice President of ... Analyst, Divyaa Ravishankar and Unmesh Lal, Program Manager , ... witnessing an exceptional era. Several new demand spaces, such as innovative ...
(Date:6/23/2016)... announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered in Bogota. Colombia ... ... ... ... Astellas is a pharmaceutical ...
Breaking Medicine Technology: