Navigation Links
UCSB researchers develop drug delivery system using nanoparticles and lasers
Date:9/10/2009

(Santa Barbara, Calif.) Researchers at UC Santa Barbara have developed a new way to deliver drugs into cancer cells by exposing them briefly to a non-harmful laser. Their results are published in a recent article in ACS Nano, a journal of the American Chemical Society.

"This entirely novel tool will allow biologists to investigate how genes function by providing them with temporal and spatial control over when a gene is turned on or off," explained Norbert Reich, senior author and a professor in the Department of Chemistry and Biochemistry at UCSB. "In a nutshell, what we describe is the ability to control genes in cells and we are working on doing this in animals simply by briefly exposing them to a non-harmful laser."

The scientists used cancer cells from mice, and grew them in culture. They then introduced gold nanoshells, with a peptide-lipid coating, that encapsulated "silencing ribonucleic acid" (siRNA), which was the drug that was taken up by the cells. Next, they exposed the cells to a non-harmful infrared laser.

"A major technical hurdle is how to combine multiple biochemical components into a compact nanoparticle which may be taken up by cells and exist stably until the release is desired," said Gary Braun, first author and a graduate student in UCSB's Department of Chemistry and Biochemistry. "Laser-controlled release is a convenient and powerful tool, allowing precise dosing of particular cells within a group. The use of biologically friendly tissue penetration with near-infrared light is the ideal for extending this capability into larger biological systems such as tissues and animals."

The authors demonstrated, for the first time, the delivery of a potent siRNA cargo inside mammalian cancer cells, released by exposing the internalized nanoparticles for several seconds to a pulsed near-infrared laser tuned for peak absorption with a specific spatial pattern. The technique can be expanded to deliver numerous drug molecules against diverse biological targets.


'/>"/>

Contact: Gail Gallessich
gail.g@ia.ucsb.edu
805-893-7220
University of California - Santa Barbara
Source:Eurekalert  

Related medicine news :

1. University of Arizona researchers seek safer cystic fibrosis test
2. UAB researchers find TB-prevention therapy is cost-effective option
3. U of T researchers identify protein
4. University of Georgia researchers show component of mothballs is present in deep-space clouds
5. Researchers link inflammatory diseases to increased cardiovascular risk
6. Researchers Make Insulin-Producing Cells From Adult Skin Cells
7. Researchers identify protein involved in causing gum disease, osteoporosis, arthritis
8. Researchers find high-dose therapy for liver disease not effective
9. Researchers identify new, cancer-causing role for protein
10. Carnegie Mellon Researchers Develop Novel Tool to Rank Death Rates
11. Researchers evaluate resistance training for diabetes prevention
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UCSB researchers develop drug delivery system using nanoparticles and lasers
(Date:2/13/2016)... ... , ... Valentine’s Day is nearly upon us, and most singles could probably ... flawless hair, and a sparkling personality are all well and good, but if somebody ... home with Rover. (Actually, man’s best friend might not even want to be near ...
(Date:2/13/2016)... ... February 13, 2016 , ... In its newly ... vein visualization technology should be used to ensure patient safety when placing an ... INS Standards mandate the use of vein visualization technology in patients with difficult ...
(Date:2/12/2016)... ... 12, 2016 , ... According to an article published February 4th ... significant portion of hernia repairs throughout the United States. Commenting on this article, Beverly ... that this trend has not only been expected, but it seems to be a ...
(Date:2/12/2016)... ... February 12, 2016 , ... CDRH Enforcement Trends: , Back to the Future , ... , As Winston Churchill said, “Those who don’t learn from history are doomed to ... expect when they come knocking this year. But that takes time. , Take a ...
(Date:2/12/2016)... ... February 12, 2016 , ... T.E.N., a ... closed for the ISE Southeast Awards 2016. Finalists and winners of the ISE® ... Southeast Executive Forum and Awards Gala on March 15, 2016 at the Westin ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... February 12, 2016 ... vermerkt)   http://www.sedar.com ) und ... abrufbar.    --> http://www.sedar.com ... http://www.telestatherapeutics.com abrufbar.    --> ... heute seinen Konzernabschluss des zweiten Quartals ...
(Date:2/12/2016)...  Memorial Hermann Health System has teamed up with ... bring a one-of-a-kind experience to pediatric patients at ... as 360-degree video and Google Cardboard, Howard was able ... giving the patients and their families an unexpected, and ... on video . Memorial Hermann IRONMAN ...
(Date:2/12/2016)... , Feb. 12, 2016  Eli Lilly and Company ... Court decided the Alimta® (pemetrexed disodium) vitamin regimen patent would ... the UK, France , Italy ... to dilute the product only with dextrose solution.  ... 2015, the UK Court of Appeal held that Lilly,s patent ...
Breaking Medicine Technology: