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UCSB researcher finds origin of inherited gene mutation causing early-onset Alzheimer's
Date:12/4/2013

ombia's Antioquian region. Kosik's co-author Francisco Lopera examined local historical and genealogical books, last wills and ecclesiastical records dating as far back as 1540.

When the scientists examined the DNA patterns around the gene mutation site, they found markers from the Iberian peninsula. They estimated the age and geographic origin of E280A to be consistent with a single founder dating from the time of the Spanish Conquistadors who began colonizing Colombia during the early 16th century.

"This doesn't have big medical implications, but it shows that genetics is a very powerful tool and can be used to reconstruct history," Kosik said. "What we've done here might be called 'neuroarchaeology.' "


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Contact: Julie Cohen
julie.cohen@ia.ucsb.edu
805-893-7220
University of California - Santa Barbara
Source:Eurekalert  

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