Navigation Links
UCSB develops breakthrough technology in identification of prostate cancer cells
Date:9/19/2011

(Santa Barbara, Calif.) A team of researchers at UC Santa Barbara has developed a breakthrough technology that can be used to discriminate cancerous prostate cells in bodily fluids from those that are healthy. The findings are published this week in the Proceedings of the National Academy of Sciences.

While the new technology is years away from use in a clinical setting, the researchers are nonetheless confident that it will be useful in developing a microdevice that will help in understanding when prostate cancer will metastasize, or spread to other parts of the body.

"There have been studies to find the relationship between the number of cancer cells in the blood, and the outcome of the disease," said first author Alessia Pallaoro, postdoctoral fellow in UCSB's Department of Chemistry and Biochemistry. "The higher the number of cancer cells there are in the patient's blood, the worse the prognosis.

"The cancer cells that are found in the blood are thought to be the initiators of metastasis," Pallaoro added. "It would be really important to be able to find them and recognize them within blood or other bodily fluids. This could be helpful for diagnosis and follow-ups during treatment."

The researchers explained that although the primary tumor does not kill prostate cancer patients, metastasis does. "The delay is not well understood," said Gary Braun, second author and postdoctoral fellow in the Department of Molecular, Cellular, and Developmental Biology. "There is a big focus on understanding what causes the tumor to shed cells into the blood. If you could catch them all, then you could stop metastasis. The first thing is to monitor their appearance."

The team developed a novel technique to discriminate between cancerous and non-cancerous cells using a type of laser spectroscopy called surface enhanced Raman spectroscopy (SERS) and silver nanoparticles, which are biotags.

"Silver nanoparticles emit a rich set of colors when they absorb the laser light," said Braun. "This is different than fluorescence. This new technology could be more powerful than fluorescence."

The breakthrough is in being able to include more markers in order to identify and study unique tumor cells that are different from the main tumor cells, explained Pallaoro. "These different cells must be strong enough to start a new tumor, or they must develop changes that allow them to colonize in other areas of the body," she said. "Some changes must be on the surface, which is what we are trying to detect."

The team is working to translate the technology into a diagnostic microdevice for studying cancer cells in the blood. Cells would be mixed with nanoparticles and passed through a laser, then discriminated by the ratio of two signals.

The two types of biotags used in this research have a particular affinity that is dictated by the peptide they carry on their surface. One type attaches to a cell receptor called neuropilin-1, a recently described biomarker found on the surface membrane of certain cancer cells. The other biotag binds many cell types (both cancerous and non-cancerous) and serves as a standard measure as the cells are analyzed.

In this study, the team mixed the two biotags and added them to the healthy and tumor cell cultures. The average SERS signal over a given cell image yielded a ratio of the two signals consistent with the cells' known identity.

Pallaoro said she believes the most important part of the new technique is the fact that it could be expanded by adding more colors different particles of different colors as more biomarkers are found. The team used a new biomarker discovered by scientists at UCSB and the Sanford Burnham Medical Research Institute.


'/>"/>

Contact: Gail Gallessich
gail.g@ia.ucsb.edu
805-893-7220
University of California - Santa Barbara
Source:Eurekalert  

Related medicine news :

1. USC scientist develops virus that targets HIV
2. JRC develops new testing methods for contaminated sports drinks from Taiwan
3. Carnegie Mellon develops iPhone app that predicts when bus will arrive
4. University of Leicester develops test for classifying force used in bottle stabbings
5. UT Southwestern pediatric urologist develops procedure to eliminate scarring in kidney surgeries
6. In the lab and clinic, VCU Massey develops a new therapy for blood cancers
7. New grant to study how pediatric brain tumor, ependymoma, develops
8. CHEO Research Institute develops secure protocol for data disclosure
9. Queens develops new brain training app for research into aging minds
10. 1 in 5 Kids With Cold Develops Middle Ear Infection: Study
11. Mount Sinai develops first screening tool for war veterans to assess traumatic brain injury
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UCSB develops breakthrough technology in identification of prostate cancer cells
(Date:5/4/2016)... ... May 04, 2016 , ... Natalie Jill ... local company MitoXcell in preparation of the launch of her new book: Natalie Jill’s ... is a nutritional guide designed to jump start a new healthy lifestyle featuring simple ...
(Date:5/4/2016)... Durham, NC (PRWEB) , ... May 04, 2016 ... ... healthcare professionals in medical coding, billing and compliance. In upcoming months, AudioEducator has ... on various specialties. Every conference is designed to give complete compliance know-how and ...
(Date:5/4/2016)... Los Angeles, California (PRWEB) , ... May 04, 2016 , ... ... for Cancer Research (AACR) honors the month of May as National Cancer Research Month. ... to 1.6 million new diagnoses of cancer with predications of one in four Americans ...
(Date:5/4/2016)... ... May 04, 2016 , ... ... that their Vasont Universal Integrator (VUI) extension supports the latest release of Adobe ... Adobe FrameMaker 2015 interlace the process of creating, editing and storing XML. ...
(Date:5/3/2016)... ... 2016 , ... ProIntro Glitch is a set of 30 self-animating glitch-themed intros ... users to add a terrifying opener to any video or media. Choose from unique ... add greater contrast, all the user has to do is increase the turn on ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... In March, 2016, Rx-360 ... free workshops across Africa ... Good Distribution Practices (GDP). Good Distribution Practice is ... are consistently stored, transported and handled under suitable conditions as ... Only a few years ago, there were few ...
(Date:5/4/2016)... 4, 2016 Research ... "Global Multiple Myeloma Market and Competitive Landscape ...      (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ... Competitive Landscape Highlights 2016, provides comprehensive insights ... epidemiology, Multiple Myeloma market valuations and forecast, ...
(Date:5/4/2016)... , May 4, 2016 ... addition of the  "Global Acute Myeloid Leukemia ...  report to their offering.       ... Acute Myeloid Leukemia Market and Competitive Landscape ... Myeloid Leukemia pipeline products, Acute Myeloid Leukemia ...
Breaking Medicine Technology: