Navigation Links
UCR researcher identifies mechanism malaria parasite uses to spread in red blood cells
Date:2/18/2010

RIVERSIDE, Calif. Malaria remains one of the most deadly infectious diseases. Yet, how Plasmodium, the malaria parasite, regulates its infectious cycle has remained an enigma despite decades of rigorous research.

But now a research team led by a cell biologist at the University of California, Riverside has identified a mechanism by which Plasmodium intensively replicates itself in human blood to spread the disease.

"If this mechanism can be stopped," said Karine Le Roch, an assistant professor of cell biology and neuroscience, who led the research, "Plasmodium replication would cease or be severely inhibited, thus controlling the spread of malaria."

In the cells of eukaryotes, such as the unicellular Plasmodium and humans, DNA, which can be as long as two meters, is closely packed to fit into the cell's tiny nucleus. Huge complex proteins called nucleosomes facilitate this DNA compaction so that eventually the DNA is coiled in an ordered manner to form chromosomes.

Made up of histone, a kind of protein, the nucleosomes are repeating units around which the double helix of DNA gets wrapped and vast amounts of genetic information get organized.

In trying to understand how the malaria parasite multiplies in red blood cells, Le Roch's team found that in Plasmodium a kind of "histone crash" takes place a massive breakdown of histone that explains how the parasite can replicate extensively its DNA and coding gene in human red blood cells.

For cell multiplication to occur, the genes in a DNA strand need to first be transcribed and translated (converted) into protein. For this transcription to take place, however, the nucleosomes must first get evicted (removed), a process that opens up the DNA strand to give special "transcription factors" full acce
'/>"/>

Contact: Iqbal Pittalwala
iqbal@ucr.edu
951-827-6050
University of California - Riverside
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Penn researchers find genetic link to leukemias with an unknown origin
2. MSU researcher links potentially deadly infection, frequent cow exposure
3. Researchers discover second protective role for tumor-suppressor
4. Researchers chart genomic map spanning over 2 dozen cancers
5. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
6. Clemson researchers develop hands-free texting application
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
9. UT researcher receives $2.4 million to research obesity, high-risk pregnancy
10. MSU researcher linking breast cancer patients with alternative therapies
11. Researchers create drug to keep tumor growth switched off
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UCR researcher identifies mechanism malaria parasite uses to spread in red blood cells
(Date:7/30/2014)... that could help doctors decide which bladder cancer patients ... effective, according to a study* published in the ... from The University of Manchester, funded by the Medical ... high levels of a protein, called ,HIF-1α, were more ... with carbon dioxide gas and nicotinamide tablets at ...
(Date:7/30/2014)... CA (July 30, 2014) With the advent of ... a popular science and researchers must work to ... study of stroke rehabilitation. A new study out ... systematic shift in perspective and suggests that chronically ... strongly promote stroke motor recovery, for example by ...
(Date:7/30/2014)... percent of Parkinson,s disease (PD) patients and their ... challenge: the occurrence of impulse control disorders (ICDs) ... spending. Yet the presence of PD in these ... A team of investigators from the Perelman School ... the Parkinson,s Disease Research, Education and Clinical Center ...
(Date:7/30/2014)... Europe commercial aviation actuation system market is estimated at ... reach $1,686.72 million by 2019 at a CAGR of ... of opportunities and challenges which will assume prominence in ... in the past, yet the sector has regained quickly, ... growth rate of approximately 5 % per year. Despite ...
(Date:7/30/2014)... (PRWEB) July 30, 2014 Bringing Disney ... September event hosted by the Central Iowa Chapter of ... Institute is bringing its renowned professional development course, “Disney’s ... 16, 2014. The full-day world class workshop will inspire ... business results, retain employees and satisfy customers. , “Disney ...
Breaking Medicine News(10 mins):Health News:Scientists pinpoint bladder cancer patients who could benefit from 'tumor-softening' treatment 2Health News:Neuro researchers advocate for a shift in thinking for stroke rehabilitation 2Health News:Penn researchers: Naltrexone may diminish impulse control disorders in Parkinson's disease patients 2Health News:Europe Aviation Actuation System Market is Expected to Reach $1,686.72 Million in 2019 - New Report by MicroMarket Monitor 2Health News:Europe Aviation Actuation System Market is Expected to Reach $1,686.72 Million in 2019 - New Report by MicroMarket Monitor 3Health News:Europe Aviation Actuation System Market is Expected to Reach $1,686.72 Million in 2019 - New Report by MicroMarket Monitor 4Health News:Central Iowa Chapter of ATD Hosts Exclusive Disney Institute for Central Iowa Businesses 2Health News:Central Iowa Chapter of ATD Hosts Exclusive Disney Institute for Central Iowa Businesses 3
... CHICAGO, June 17 Continuing its efforts to educate, inform, ... not-for-profit patient-focused organization, is hosting its 25-minute live call-in show, ... June 22, 2009 at 6:00 PM on Channel 21. ... discussion with Deborah Harper Brown, Clinical Pharmacist, who will inform ...
... Registration is underway for the CPAP SUCCESS GROUP being held at ... Monday, July 6 at 4PM at 541 Main Street in the ... designed to help struggling CPAP users become better accustomed to CPAP ... and effectively by learning simple relaxation techniques that promote breathing normally ...
... release of the IntelliFlowRx workflow management system provides ... , ENGLEWOOD, Colo., June 17 Baxa Corporation ... workflow management system. IntelliFlowRx is designed to ... preparation. The system also streamlines compliance with ...
... gene, variant ups violence inclination, study finds , WEDNESDAY, June 17 ... blamed for boys joining violent street gangs. But a new study ... in part, in their genes. , Boys who have a variant ... the "warrior gene" -- are not only more likely to be ...
... , - SLA Centennial Observance ... Century , Elsevier has been awarded ... BioMedicine and the Life Sciences" at the Special Library,Association,s (SLA) ... published by Elsevier, many on behalf of renowned,societies, were also ...
... Recognizes Entrepreneurial Excellence in Health and Life Sciences Category , ... -- Accuray Incorporated (Nasdaq: ARAY ), a ... Euan Thomson, Ph.D., the company,s president and CEO, received the ... the Health and Life Sciences category in Northern California. ...
Cached Medicine News:Health News:The Consumer's Role in Medication Safety -- An Interactive Discussion with a Pharmacist on Live TV 2Health News:Help for Struggling CPAP Users Comes to Sleep HealthCenters in Weymouth 2Health News:Baxa Corporation Releases IntelliFlowRx(TM) Upgrades 2Health News:Boys May Feel a Genetic Pull Toward Gangs 2Health News:Elsevier Honored as "The Most Influential Publisher of the Last 100 Years in BioMedicine and the Life Sciences" by the Special Libraries Association 2Health News:Elsevier Honored as "The Most Influential Publisher of the Last 100 Years in BioMedicine and the Life Sciences" by the Special Libraries Association 3Health News:Elsevier Honored as "The Most Influential Publisher of the Last 100 Years in BioMedicine and the Life Sciences" by the Special Libraries Association 4Health News:Accuray's Euan Thomson Named Ernst & Young Entrepreneur Of The Year(R) 2009 Award Recipient in Northern California 2Health News:Accuray's Euan Thomson Named Ernst & Young Entrepreneur Of The Year(R) 2009 Award Recipient in Northern California 3
(Date:7/30/2014)... 30, 2014 Research and Markets ... Chinese Aseptic Packaging Industry Report 2014" report to ... The Global and Chinese Aseptic Packaging Industry ... current state of the global Aseptic Packaging industry with ... provides a basic overview of the industry including definitions, ...
(Date:7/30/2014)... N.J. , July 30, 2014  InnoPharma, Inc. ... Injection, 10mg/vial (the generic equivalent of Zyprexa® injection), in ... agitation and disturbed behaviors in patients with schizophrenia or ... this generic injectable drug, InnoPharma has entered into an ... Sandoz Canada will make, use, sell, market and ...
(Date:7/30/2014)... YORK and KISSING, Germany ... and distributor of a single use and computer-assisted ("robotic") ... (Homi) Shamir , a worldwide recognized medical device executive, ... Mr. Shamir is a highly respected global ... recent assignment he served as President and Chief Executive ...
Breaking Medicine Technology:Global and Chinese Aseptic Packaging Industry Report 2014 2InnoPharma Announces Launch of Olanzapine for Injection, 10mg/vial in Canada 2invendo medical Appoints Nachum (Homi) Shamir To The Company's Board Of Directors 2invendo medical Appoints Nachum (Homi) Shamir To The Company's Board Of Directors 3
... Okla., March 9, 2011 Sandra Smith filed suit today ... over a failed hip replacement system from Johnson & Johnson, ... market.  John David Hart of the Law Offices of John ... Ms. Smith. Smith, of Yukon, underwent surgeries ...
... Inc. (NYSE: WST ) today announced that management ... Miami, FL.  Management will present an overview of West,s business ... ET. A live audio webcast of the Company,s ... will be accessible from the Company,s website at www.westpharma.com/en/investors ...
Cached Medicine Technology:Woman Files Suit in Federal Court Against DePuy Orthopaedics, Inc.,/Johnson & Johnson Over Recalled Hip Device 2
... quality patient care., ,S/5 Anesthesia Delivery ... anesthesia delivery. As part of the S/5 ... electronically controlled gas delivery and agent vaporization ... create a truly integrated system. The S/5 ...
... filler and Tegagel hydrogel wound filler ... specially formulated to help provide a ... to enhance wound healing. The unique, ... for management of non-draining, minimally draining ...
... SS is a complete physician preference card ... management system for all the supply management ... preference card system combined with a broad ... entire case cart and operating suite supply ...
Easy to Use manual vacuum system features a pumping mechanism that can be operated with one hand....
Medicine Products: